{"title":"All Peptides","description":"\u003cp\u003eExplore our complete catalog of research-grade peptides, spanning multiple categories including anti-aging, muscle building, cognitive function, recovery, and more. Every peptide is synthesized to pharmaceutical standards with ≥98% purity.\u003c\/p\u003e\n\n\u003ch3\u003eWhy Choose Peptides BioLab\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVerified Purity:\u003c\/strong\u003e All peptides tested to ≥98% purity via HPLC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of Analysis:\u003c\/strong\u003e Batch-specific COA included with every order\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGMP Manufacturing:\u003c\/strong\u003e Produced in certified facilities under strict quality control\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch Grade:\u003c\/strong\u003e Pharmaceutical-quality compounds for serious research applications\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast Shipping:\u003c\/strong\u003e Discreet packaging with temperature-controlled delivery\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePopular Research Categories\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGrowth Hormone Secretagogues (Ipamorelin, CJC-1295, GHRP-6)\u003c\/li\u003e\n\u003cli\u003eRecovery \u0026amp; Healing (BPC-157, TB-500, GHK-Cu)\u003c\/li\u003e\n\u003cli\u003eCognitive Enhancement (Semax, Selank, Dihexa)\u003c\/li\u003e\n\u003cli\u003eAnti-Aging \u0026amp; Longevity (Epitalon, SS-31, Thymosin Alpha-1)\u003c\/li\u003e\n\u003cli\u003eMuscle Building (Follistatin-344, IGF-1 LR3, PEG-MGF)\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cstrong\u003eResearch Use Only:\u003c\/strong\u003e All Peptides BioLab products are intended for in-vitro research applications only. Not for human or animal consumption. Each product includes safety data and handling guidelines.\u003c\/p\u003e","products":[{"product_id":"glutathione-1500mg","title":"Glutathione 1500MG","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGlutathione — Master Antioxidant Tripeptide for Redox Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGlutathione\u003c\/strong\u003e (GSH) is the most abundant intracellular thiol antioxidant, present at millimolar concentrations in virtually all cells. The GSH\/GSSG ratio is a critical indicator of cellular redox status, with perturbations linked to numerous pathological conditions.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eGlutathione scavenges ROS\/RNS directly, serves as cofactor for GPx and GST families, maintains protein thiol states, and recycles vitamins C and E. Depletion below 30% triggers mitochondrial dysfunction and apoptosis (\u003cem\u003eFree Radical Biology and Medicine\u003c\/em\u003e).\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOxidative Stress Research:\u003c\/strong\u003e Benchmark antioxidant in redox biology — GSH supplementation and depletion protocols study how redox balance influences signaling and cell fate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Function:\u003c\/strong\u003e Mitochondrial GSH pool protects electron transport chain and cardiolipin; depletion is an early apoptotic event.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDetoxification:\u003c\/strong\u003e GST enzymes conjugate glutathione to electrophilic substrates for phase II detoxification research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune Cell Function:\u003c\/strong\u003e Intracellular GSH levels regulate lymphocyte proliferation, NK cytotoxicity, and Th1\/Th2 balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGlutathione\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/glutathione-1500mg\"\u003eGlutathione\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e, \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751379274,"sku":"PBL-GLUTATHIONE1500MG-10MG","price":44.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-glutathione-antioxidant-1500mg-research-grade.webp?v=1773933882"},{"product_id":"pinealon","title":"Pinealon","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePinealon — Short Bioregulatory Peptide for Neuroprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePinealon\u003c\/strong\u003e (Glu-Asp-Arg) is a synthetic tripeptide bioregulator by Professor Khavinson. Targets brain tissue, penetrates cell membranes, and interacts with DNA sequences to modulate neuronal survival, differentiation, and antioxidant defense genes.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePinealon belongs to Khavinson's short bioregulatory peptides interacting with DNA in promoter regions. Modulates MAP2, synaptophysin, Bcl-2 expression. Protects cortical neurons against H2O2-induced oxidative stress, maintaining mitochondrial membrane potential and reducing caspase-3 (\u003cem\u003ePeptides\u003c\/em\u003e, 2011). Also influences melatonin synthesis in pinealocytes.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Protective against oxidative stress-induced neuronal death, maintaining viability and mitochondrial function under apoptotic conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpigenetic Gene Regulation:\u003c\/strong\u003e Modulates chromatin condensation and gene accessibility in a sequence-specific manner — novel peptide-DNA interaction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrain Aging:\u003c\/strong\u003e Effects on cognitive function markers, hippocampal neurogenesis, and neurotransmitter metabolism in aged models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePineal Gland Function:\u003c\/strong\u003e Effects on melatonin synthesis enzyme expression and circadian rhythm-related gene activity in pinealocytes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePinealon\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/epithalon\"\u003eEpitalon\u003c\/a\u003e, \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, and \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751412042,"sku":"PBL-PINEALON-10MG","price":49.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pinealon-neuropeptide-10mg-research-grade.webp?v=1773933892"},{"product_id":"semax-selank","title":"Semax\/Selank","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSemax \/ Selank Nootropic Blend — Dual-Peptide Combination for Cognitive and Neuromodulatory Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eSemax \/ Selank Blend\u003c\/strong\u003e combines two complementary neuropeptides. Semax (ACTH 4-10 analog) upregulates BDNF\/NGF and monoaminergic transmission. Selank (tuftsin analog) modulates GABAergic tone and enkephalin metabolism. Dual-mechanism for cognitive enhancement and stress resilience.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSemax increases BDNF\/NGF through MAPK\/ERK, enhances 5-HT and DA transmission. Selank allosterically enhances GABA-A, inhibits enkephalinase, modulates 36 hippocampal genes. Semax enhances performance while Selank reduces anxiety without sedation — cognitive enhancement under reduced stress reactivity.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComplementary Neurochemistry:\u003c\/strong\u003e Semax enhances excitatory neurotrophic pathways while Selank strengthens inhibitory tone — balanced excitation\/inhibition for cognitive outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF and GABAergic Integration:\u003c\/strong\u003e Simultaneous BDNF upregulation (LTP\/plasticity) and GABA enhancement (signal-to-noise refinement) — optimal learning conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStress-Cognition Interaction:\u003c\/strong\u003e Anxiolytic (Selank) + cognitive enhancement (Semax) — how stress reduction influences cognitive performance and vice versa.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune-Neural Integration:\u003c\/strong\u003e Both retain parent molecule immunomodulatory properties — intersection of neuroimmune signaling with cognitive function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSemax \/ Selank Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/semax-selank\"\u003eSemax \/ Selank Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751444810,"sku":"PBL-SEMAXSELANK-10MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-semax-selank-nootropic-blend-20mg-research-grade.webp?v=1773933895"},{"product_id":"slu-pp-332","title":"SLU-PP-332","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSLU-PP-332 — ERRα\/γ Agonist for Exercise Mimetic and Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSLU-PP-332\u003c\/strong\u003e is a synthetic ERRα\/ERRγ agonist developed at Saint Louis University (\u003cem\u003eACS Chemical Biology\u003c\/em\u003e, 2023). These orphan nuclear receptors are master regulators of mitochondrial biogenesis and oxidative metabolism. Novel exercise mimetic activating endurance-exercise transcriptional programs.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSLU-PP-332 stabilizes active conformations of ERRα\/ERRγ, enhancing transcription of PGC-1α, NRF1, TFAM, CPT1b, and oxidative phosphorylation complex genes. Increased fatigue-resistant fiber content and running endurance in mouse models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Mimetic Research:\u003c\/strong\u003e Recapitulates endurance training adaptations: fiber type shifting, mitochondrial density, oxidative capacity — via pharmacological ERR activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eERR Nuclear Receptor Biology:\u003c\/strong\u003e One of few validated ERRα\/γ agonists — separates ERR-dependent from ERR-independent exercise adaptations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Biogenesis:\u003c\/strong\u003e Drives PGC-1α\/NRF1\/TFAM cascade for mitochondrial DNA replication and respiratory chain assembly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFiber Type Specification:\u003c\/strong\u003e Increased slow-twitch myosin expression and oxidative enzyme activity — molecular determinants of fiber type composition.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSLU-PP-332\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/slu-pp-322\"\u003eSLU-PP-332\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751477578,"sku":"PBL-SLU-PP-332-10MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-slu-pp-332-exercise-mimetic-5mg-research-grade.webp?v=1773933897"},{"product_id":"snap-8","title":"SNAP 8","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSNAP-8 — Acetyl Octapeptide-3 for SNARE Complex and Neuromuscular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSNAP-8\u003c\/strong\u003e (Acetyl Octapeptide-3) is derived from SNAP-25 N-terminal domain, competitively inhibiting SNARE complex assembly at the neuromuscular junction to reduce vesicular neurotransmitter exocytosis.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSNAP-8 competes with endogenous SNAP-25 for syntaxin-1 binding, destabilizing SNARE complex formation and reducing vesicle docking efficiency. Dose-dependent catecholamine release reduction in chromaffin cell models confirms the mechanism.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSNARE Complex Biology:\u003c\/strong\u003e Non-toxic pharmacological tool for studying SNARE-mediated membrane fusion without botulinum neurotoxin irreversibility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromuscular Junction Research:\u003c\/strong\u003e Dose-dependent neuromuscular transmission attenuation — reversible model for synaptic function studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExocytosis and Vesicle Trafficking:\u003c\/strong\u003e Studies SNARE complex assembly kinetics and individual SNARE protein contributions to regulated exocytosis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTopical Peptide Delivery:\u003c\/strong\u003e Model compound for investigating peptide delivery across biological barriers and topical bioactive pharmacology.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSNAP-8\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/snap-8\"\u003eSNAP-8\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eDermatological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751674186,"sku":"PBL-SNAP8-6G","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-snap-8-acetyl-octapeptide-10mg-research-grade.webp?v=1773933898"},{"product_id":"ara-290","title":"Ara-290","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eARA-290 — Innate Repair Receptor Agonist for Neuroprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eARA-290\u003c\/strong\u003e (Cibinetide) is an 11-amino acid peptide derived from erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a heterocomplex of EPO receptor and CD131. Unlike EPO, it does not stimulate erythropoiesis. Published in \u003cem\u003eMolecular Medicine\u003c\/em\u003e (2008) by Brines et al.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eARA-290 binds the IRR heterocomplex, triggering JAK2\/STAT5 and PI3K\/Akt cascades that promote cell survival and modulate inflammatory cytokines. It suppresses NF-κB activation and reduces TNF-α, IL-6, IL-1β in macrophage models. In neural tissue, it protects against ischemia-reperfusion injury.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Promotes nerve fiber regeneration and restores sensory function in sciatic nerve injury models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory Signaling:\u003c\/strong\u003e Shifts macrophage polarization from M1 to M2 (reparative) phenotypes in chronic inflammation models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Neuropathy:\u003c\/strong\u003e Preserves intraepidermal nerve fiber density in diabetic neuropathy models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue-Protective Signaling:\u003c\/strong\u003e Activates cytoprotective pathways independent of erythropoiesis for clean tissue repair research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eARA-290\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ara-290\"\u003eARA-290\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751706954,"sku":"PBL-ARA-290-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ara-290-peptide-10mg-research-grade.webp?v=1773933873"},{"product_id":"ll-37","title":"LL-37","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eLL-37 — Human Cathelicidin Antimicrobial Peptide for Innate Immunity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLL-37\u003c\/strong\u003e is a 37-amino acid cationic antimicrobial peptide — the only human cathelicidin. Cleaved from hCAP18 by proteinase 3, it adopts an amphipathic alpha-helix for membrane disruption. Sequenced by Gudmundsson et al. (1996). Active against bacteria, fungi, and enveloped viruses.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eLL-37 disrupts microbial membranes through electrostatic attraction to anionic phospholipids via carpet model, toroidal pore, and membrane thinning mechanisms. Also activates FPRL1, promotes chemotaxis, stimulates angiogenesis, and modulates TLR signaling. Forms DNA complexes activating dendritic cells via TLR9 (\u003cem\u003eNature Medicine\u003c\/em\u003e).\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntimicrobial Mechanisms:\u003c\/strong\u003e Broad-spectrum activity against Gram+\/- bacteria, fungi, viruses. Physical mode of action resists pathogen adaptation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInnate Immune Signaling:\u003c\/strong\u003e Activates FPRL1, P2X7, EGFR, triggering chemotaxis and cytokine responses bridging innate and adaptive immunity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing:\u003c\/strong\u003e EGFR transactivation stimulates keratinocyte migration for re-epithelialization.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiofilm Research:\u003c\/strong\u003e Anti-biofilm activity at sub-MIC concentrations against P. aeruginosa and S. aureus.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eLL-37\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eImmunomodulatory Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751739722,"sku":"PBL-LL-37-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ll-37-antimicrobial-peptide-5mg-research-grade.webp?v=1773933885"},{"product_id":"kpv","title":"KPV","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eKPV — Alpha-MSH C-Terminal Tripeptide for Anti-Inflammatory Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKPV\u003c\/strong\u003e (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH, retaining anti-inflammatory properties without melanocortin receptor-mediated melanogenic activity. Characterized by Brzoska et al. (\u003cem\u003eFEBS Letters\u003c\/em\u003e, 1999).\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eKPV inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation, suppressing IL-1β, IL-6, and TNF-α. Enters cells directly for receptor-independent effects. Reduces inflammation in colitis models through direct intestinal epithelial cell signaling (\u003cem\u003eJ Immunol\u003c\/em\u003e). Modulates NLRP3 inflammasome.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNF-κB Pathway:\u003c\/strong\u003e Inhibits NF-κB at multiple cascade points without broad receptor pharmacology of full-length α-MSH.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntestinal Inflammation:\u003c\/strong\u003e Demonstrated anti-inflammatory effects in DSS-colitis and IBD models with reduced mucosal damage and neutrophil infiltration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Inflammation:\u003c\/strong\u003e Reduces IL-8 and TNF-α in UV-irradiated and LPS-stimulated skin cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInnate Immune Modulation:\u003c\/strong\u003e Modulates macrophage and dendritic cell inflammatory responses while preserving antimicrobial functions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eKPV\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eImmunomodulatory Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751772490,"sku":"PBL-KPV-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-kpv-anti-inflammatory-peptide-10mg-research-grade.webp?v=1773933883"},{"product_id":"thymosin-alpha-1","title":"Thymosin Alpha-1","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eThymosin Alpha-1 — Thymic Peptide for Dendritic Cell Maturation and Immune Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eThymosin Alpha-1\u003c\/strong\u003e (Tα1) is a 28-amino acid thymic peptide (Goldstein et al., 1977). Over 4,400 published articles and 80+ clinical trials. Biological response modifier enhancing innate and adaptive immunity through dendritic cell maturation, T-cell differentiation, and TLR signaling. Approved in 35+ countries.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eTα1 activates TLR2 and TLR9, promoting dendritic cell maturation with increased MHC I\/II, CD80\/CD86, and IL-12 secretion. Drives Th1 differentiation, enhances NK cell cytotoxicity, and stimulates B cell antibody production. Activates p38 MAPK and NF-κB in TLR-dependent manner.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDendritic Cell Biology:\u003c\/strong\u003e Promotes DC maturation and functional competence — enhanced antigen processing, MHC expression, T-cell priming.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eT-Cell Differentiation:\u003c\/strong\u003e Drives CD4+ Th1 polarization and enhances CD8+ cytotoxic function — T-cell polarization mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTLR Signaling Research:\u003c\/strong\u003e Activates TLR2\/TLR9 — studies how thymic peptides modulate pathogen recognition receptors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune Senescence:\u003c\/strong\u003e Partially reverses age-associated immune decline, restoring T-cell repertoire diversity and NK function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eThymosin Alpha-1\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e, \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e, and \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eImmunomodulatory Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751805258,"sku":"PBL-THYMOSINALPHA-1-60G","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-thymosin-alpha-1-immune-peptide-10mg-research-grade.webp?v=1773933903"},{"product_id":"ghrp-6","title":"GHRP-6","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHRP-6 — Hexapeptide Ghrelin Receptor Agonist for GH Secretion Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHRP-6\u003c\/strong\u003e is a synthetic hexapeptide GHS-R1a agonist developed by Bowers et al. (\u003cem\u003eEndocrinology\u003c\/em\u003e, 1984). Among the earliest synthetic GH secretagogues, it stimulates pituitary GH release through a mechanism distinct from GHRH.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eGHRP-6 binds GHS-R1a, activating PLC and IP3\/DAG signaling for calcium release and GH exocytosis. Complementary to GHRH (cAMP-PKA), explaining synergistic GH release when combined. Also suppresses somatostatin and stimulates appetite via NPY\/AgRP neurons.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Secretagogue Research:\u003c\/strong\u003e Robust dose-dependent GH release through ghrelin receptor pathway, studying GHRH-GHS interplay.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin Receptor Biology:\u003c\/strong\u003e Reference compound for GHS-R1a pharmacology, constitutive activity, and desensitization kinetics.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppetite and Energy Balance:\u003c\/strong\u003e Stimulates food intake via central NPY\/AgRP mechanisms for orexigenic signaling research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCytoprotective Effects:\u003c\/strong\u003e Protective effects in cardiac and hepatic ischemia-reperfusion, independent of GH release.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHRP-6\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e, and \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751903562,"sku":"PBL-GHRP-6-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghrp-6-acetate-peptide-10mg-research-grade.webp?v=1773933880"},{"product_id":"ace-031","title":"ACE-031","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eACE-031 — Soluble ActRIIB Decoy Receptor for Myostatin Pathway Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1. This soluble decoy receptor binds and neutralizes members of the TGF-β superfamily, including myostatin and activins, which are negative regulators of skeletal muscle mass. Originally developed by Acceleron Pharma and studied in clinical trials for neuromuscular conditions, \u003cstrong\u003eACE-031\u003c\/strong\u003e remains a critical research tool for investigating muscle growth regulation pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e functions as a ligand trap, sequestering myostatin (GDF-8) and related TGF-β family ligands before they can bind to endogenous ActRIIB receptors on cell surfaces. By intercepting these signaling molecules, the compound effectively blocks the SMAD2\/3 phosphorylation cascade that normally suppresses muscle protein synthesis. Studies published in \u003cem\u003eMolecular and Cellular Endocrinology\u003c\/em\u003e (2010) demonstrated that ActRIIB-Fc administration in murine models resulted in significant increases in lean muscle mass, independent of physical activity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Inhibition:\u003c\/strong\u003e \u003cstrong\u003eACE-031\u003c\/strong\u003e has been extensively studied as a myostatin antagonist. In preclinical models, treatment resulted in dose-dependent increases in skeletal muscle mass, with research in \u003cem\u003eMuscle \u0026amp; Nerve\u003c\/em\u003e (2013) documenting significant effects on both fast-twitch and slow-twitch fiber types.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromuscular Disease Models:\u003c\/strong\u003e Researchers have investigated ACE-031 in the mdx mouse model of Duchenne muscular dystrophy, where it demonstrated preservation of muscle function and reduced fibrosis without directly targeting the underlying genetic defect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone Mineral Density:\u003c\/strong\u003e Published research has observed concurrent increases in bone mineral density alongside muscle mass gains, suggesting dual anabolic effects mediated through TGF-β pathway modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Regulation:\u003c\/strong\u003e ActRIIB pathway blockade has been associated with reduced adiposity in animal models, with researchers observing improved glucose tolerance and insulin sensitivity alongside muscle hypertrophy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eACE-031\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying muscle growth regulation and TGF-β signaling may also find these compounds relevant: \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751936330,"sku":"PBL-ACE-031-6G","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ace-031-peptide-1mg-research-grade.webp?v=1773933871"},{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePE-22-28 — Spadin-Derived Peptide for TREK-1 Channel Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePE-22-28\u003c\/strong\u003e is a synthetic heptapeptide from sortilin propeptide (spadin), selectively antagonizing TREK-1 potassium channels. Identified by Mazella et al. (\u003cem\u003ePNAS\u003c\/em\u003e, 2010). TREK-1 channels are highly expressed in hippocampus and cortex, regulating mood and cognition.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePE-22-28 selectively blocks TREK-1 (KCNK2), increasing neuronal firing and synaptic transmission. TREK-1 knockout mice show enhanced hippocampal neurogenesis and BDNF signaling (\u003cem\u003eBiological Psychiatry\u003c\/em\u003e). PE-22-28 recapitulates these effects: increased neurogenesis, enhanced 5-HT neurotransmission, CREB\/BDNF upregulation.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTREK-1 Channel Research:\u003c\/strong\u003e Selective pharmacological tool for studying TREK-1 influence on membrane excitability and synaptic plasticity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHippocampal Neurogenesis:\u003c\/strong\u003e Increased neural progenitor proliferation in dentate gyrus with promoted survival and neuronal differentiation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF Signaling:\u003c\/strong\u003e Upregulates BDNF via CREB-dependent mechanisms, enhancing TrkB signaling for synaptic strengthening and LTP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSerotonergic System:\u003c\/strong\u003e Enhances 5-HT firing and release in dorsal raphe nucleus for studying serotonergic mood and cognition.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePE-22-28\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751969098,"sku":"PBL-PE-22-28-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pe-22-28-nootropic-peptide-10mg-research-grade.webp?v=1773933888"},{"product_id":"ss-31","title":"SS-31","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSS-31 — Cardiolipin-Targeting Peptide for Mitochondrial Medicine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSS-31\u003c\/strong\u003e (Elamipretide) is a cell-permeable mitochondria-targeted tetrapeptide by Szeto \u0026amp; Schiller. Selectively concentrates in inner mitochondrial membrane binding cardiolipin. First-in-class compound for stabilizing mitochondrial bioenergetics (\u003cem\u003eAntioxidants \u0026amp; Redox Signaling\u003c\/em\u003e, 2014).\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSS-31 binds cardiolipin, stabilizing cytochrome c interactions and optimizing electron transfer through complexes III\/IV. Reduces electron leak and superoxide while maintaining ATP synthesis. \u003cem\u003ePNAS\u003c\/em\u003e showed reversal of age-related mitochondrial dysfunction and cristae remodeling.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Bioenergetics:\u003c\/strong\u003e Optimizes ETC function by stabilizing cardiolipin-protein interactions, reducing proton leak, increasing coupling efficiency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIschemia-Reperfusion Research:\u003c\/strong\u003e Protective effects in cardiac, renal, cerebral I\/R models with reduced infarct size and preserved organ function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Mitochondrial Decline:\u003c\/strong\u003e Reverses cristae remodeling, reduced membrane potential, and decreased ATP capacity in aged skeletal and cardiac tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiolipin Biology:\u003c\/strong\u003e First peptide shown to directly interact with and stabilize cardiolipin — new avenues for mitochondrial structure-function research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSS-31\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e, \u003ca href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e, and \u003ca href=\"\/products\/epithalon\"\u003eEpitalon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eLongevity Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995752034634,"sku":"PBL-SS-31-6G","price":44.99,"currency_code":"EUR","in_stock":true},{"title":"50","offer_id":60995752067402,"sku":"PBL-SS-31-6G","price":199.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ss-31-elamipretide-peptide-10mg-research-grade.webp?v=1773933900"},{"product_id":"vip","title":"VIP","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eVIP — Vasoactive Intestinal Peptide for Neuroimmune and Mucosal Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eVIP\u003c\/strong\u003e is a 28-amino acid neuropeptide (Said \u0026amp; Mutt, 1970). Neurotransmitter and immune modulator acting through VPAC1\/VPAC2 receptors across nervous, immune, endocrine, and GI systems. Over 10,000 published articles.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eVIP activates VPAC1\/2 via Gs-cAMP signaling. In neurons: modulates synaptic transmission and circadian rhythm (key SCN synchronizer). In immune cells: generates tolerogenic DCs, promotes Tregs, shifts Th1→Th2 (\u003cem\u003eNat Rev Immunol\u003c\/em\u003e). In gut: regulates ion transport, blood flow, smooth muscle.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroimmune Modulation:\u003c\/strong\u003e VIPergic nerves innervate lymphoid organs — studies how neuropeptide signaling regulates immune function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCircadian Clock Research:\u003c\/strong\u003e Essential for SCN neuronal synchronization. VPAC2 signaling maintains intercellular clock coupling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegulatory T-Cell Biology:\u003c\/strong\u003e Promotes FoxP3+ Treg differentiation — peripheral tolerance and immune homeostasis mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGut-Brain Axis:\u003c\/strong\u003e Abundant enteric neuropeptide regulating secretion, motility, barrier function, and mucosal immune responses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eVIP\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ara-290\"\u003eARA-290\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752100170,"sku":"PBL-VIP-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-vip-vasoactive-intestinal-peptide-10mg-research-grade.webp?v=1773933905"},{"product_id":"peg-mgf","title":"PEG MGF","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePEG-MGF — Pegylated Mechano Growth Factor for Skeletal Muscle Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePEG-MGF\u003c\/strong\u003e is a PEGylated form of the IGF-1Ec splice variant, a mechanically sensitive growth factor produced after exercise or tissue damage. PEGylation extends half-life from minutes to hours. Used in satellite cell activation and muscle hypertrophy research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePEG-MGF activates satellite cells — resident muscle stem cells — promoting proliferation and migration to damage sites. MGF exerts autocrine\/paracrine effects within muscle microenvironment. Goldspink (\u003cem\u003eJ Physiology\u003c\/em\u003e, 2003) showed MGF is an immediate early gene response to mechanical overload, preceding liver-type IGF-1Ea expression.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSatellite Cell Activation:\u003c\/strong\u003e Activates quiescent satellite cells, promoting cell cycle entry — critical first step in muscle repair and adaptive hypertrophy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechano-Transduction:\u003c\/strong\u003e MGF expression is a direct readout of mechanical loading, separating growth factor signal from mechanical stimulus.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Regeneration:\u003c\/strong\u003e Enhanced myoblast proliferation, migration, and fusion in injury models with accelerated contractile function restoration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 Splice Variant Biology:\u003c\/strong\u003e Study distinct biological roles of mechano-sensitive vs. liver-derived IGF-1 isoforms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePEG-MGF\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, and \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752165706,"sku":"PBL-PEGMGF-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-peg-mgf-peptide-2mg-research-grade.webp?v=1773933890"},{"product_id":"follistatin-344","title":"Follistatin 344","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eFollistatin 344 — Activin-Binding Glycoprotein for Myostatin Antagonism Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFollistatin 344\u003c\/strong\u003e (FST344) is a 344-amino acid glycoprotein that antagonizes activin, myostatin (GDF-8), and other TGF-β superfamily ligands. Research in \u003cem\u003eFASEB Journal\u003c\/em\u003e (2005) showed dramatic skeletal muscle mass increases in multiple animal models.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eFollistatin neutralizes TGF-β members through direct protein-protein interactions. Its three FS domains create a binding surface complementary to activin and myostatin receptor-binding epitopes, preventing ActRII\/ALK4 activation and SMAD2\/3 signaling. PNAS research showed sustained muscle mass increases in non-human primate gene delivery models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Antagonism:\u003c\/strong\u003e Binds myostatin with nanomolar affinity, preventing ActRIIB signaling. Studied for effects on muscle fiber hypertrophy and satellite cell proliferation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivin Signaling:\u003c\/strong\u003e Regulates activin A\/B signaling influencing reproductive biology, inflammatory responses, and hepatic glucose metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Therapy Models:\u003c\/strong\u003e Used in AAV-mediated gene delivery for sustained muscle mass — proof-of-concept for neuromuscular gene therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Regeneration:\u003c\/strong\u003e Enhances satellite cell activation and myoblast fusion in damaged muscle tissue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eFollistatin 344\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752198474,"sku":"PBL-FOLLISTATIN344-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-follistatin-344-myostatin-inhibitor-1mg-research-grade.webp?v=1773935005"},{"product_id":"5-amino1-mq","title":"5-Amino1-mq","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003e5-Amino-1MQ — A Selective NNMT Inhibitor for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e (5-Amino-1-methylquinolinium) is a small molecule compound that has gained significant attention in metabolic research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). First characterized in studies published by Neelakantan et al. (2017) in \u003cem\u003eBiochemical Pharmacology\u003c\/em\u003e, this compound has demonstrated notable effects on adipocyte metabolism and energy expenditure pathways in preclinical models, making it a valuable tool for researchers investigating obesity-related metabolic dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e functions by selectively inhibiting NNMT, an enzyme that regulates cellular energy metabolism through the methylation of nicotinamide. By blocking NNMT activity, this compound increases intracellular NAD+ concentrations and activates the SAM-dependent methylation cycle. In adipocyte models, NNMT inhibition has been associated with increased expression of energy expenditure genes and reduced lipogenesis. Research published in \u003cem\u003eObesity\u003c\/em\u003e (2018) demonstrated that NNMT inhibition led to significant reductions in fat mass without affecting lean tissue in murine models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdipocyte Metabolism:\u003c\/strong\u003e In-vitro studies have shown that \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e reduces lipid accumulation in 3T3-L1 adipocytes by increasing NAD+ availability and stimulating sirtuin-dependent metabolic pathways. These findings suggest potential applications in obesity-related metabolic research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNAD+ Biosynthesis:\u003c\/strong\u003e By inhibiting NNMT, this compound redirects nicotinamide toward the NAD+ salvage pathway, effectively increasing cellular NAD+ pools. This mechanism is of particular interest to researchers studying age-related NAD+ decline and mitochondrial function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy Expenditure:\u003c\/strong\u003e Preclinical studies have observed increased oxygen consumption rates and thermogenic gene expression in white adipose tissue following NNMT inhibition, indicating enhanced cellular energy expenditure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Syndrome Pathways:\u003c\/strong\u003e Researchers have investigated the compound's effects on insulin signaling and glucose homeostasis in diet-induced obesity models, with published data suggesting improvements in metabolic biomarkers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying metabolic pathways and energy expenditure may also find these compounds relevant to their work: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752296778,"sku":"PBL-5-AMINO1-MQ-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-5-amino-1mq-fat-metabolism-peptide-50mg-research-grade.webp?v=1773935006"},{"product_id":"igf1-lr3","title":"IGF1-LR3","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eIGF-1 LR3 — Long-Acting Growth Factor Analog for Proliferation Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e is an 83-amino acid analog of human IGF-1 with reduced IGFBP binding (Arg3→Glu + 13-AA N-terminal extension), resulting in extended half-life and ~3× greater potency than native IGF-1 in cell proliferation assays.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIGF-1 LR3 activates IGF-1R, triggering PI3K\/Akt\/mTOR and Ras\/Raf\/MAPK cascades. Less than 1% affinity for IGFBP-3 keeps more peptide in active form. Standard component of serum-free culture media for myoblasts, fibroblasts, and stem cells.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Culture Applications:\u003c\/strong\u003e Standard growth supplement in serum-free media for myoblasts, fibroblasts, epithelial cells, and stem cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1R Signaling:\u003c\/strong\u003e Study receptor activation kinetics, PI3K\/Akt signaling, and sustained IGF-1R stimulation effects on cell cycle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Cell Biology:\u003c\/strong\u003e Promotes myoblast proliferation, MyoD expression, and myotube formation in muscle cell cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGFBP-Independent Signaling:\u003c\/strong\u003e Reduced IGFBP binding enables clean analysis of receptor-level events without sequestration confounds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e, \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, and \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752362314,"sku":"PBL-IGF1-LR3-6G","price":89.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-igf1-lr3-insulin-growth-factor-1mg-research-grade.webp?v=1773935008"},{"product_id":"nad","title":"NAD+","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNAD+ — Essential Coenzyme for Sirtuin and Cellular Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eNAD+\u003c\/strong\u003e (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme in 500+ enzymatic reactions. Critical substrate for sirtuins (SIRT1-7), PARPs, and CD38 — regulating DNA repair, epigenetics, circadian rhythms, and inflammation. Declining NAD+ is a hallmark of aging (Imai \u0026amp; Guarente, \u003cem\u003eTrends in Cell Biology\u003c\/em\u003e, 2014).\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eNAD+ participates in redox reactions (NAD+\/NADH) and is consumed by sirtuins for protein deacetylation, linking metabolic state to epigenetic regulation. PARP1 consumes NAD+ for DNA repair. NAD+ repletion restores mitochondrial function in aged mice (\u003cem\u003eScience\u003c\/em\u003e, 2013). CD38 identified as primary driver of age-related NAD+ decline.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSirtuin Biology:\u003c\/strong\u003e Absolute requirement for SIRT1 deacetylation of PGC-1α, FOXO, and histone H3K9 — linking metabolism to gene regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDNA Repair \u0026amp; Genomic Stability:\u003c\/strong\u003e PARP1\/2 consume NAD+ for poly(ADP-ribose) chains at damage sites. Depletion compromises repair capacity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Function:\u003c\/strong\u003e NAD+\/NADH ratio drives ETC flux and ATP production. Restoring levels rescues membrane potential in aged tissues.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCircadian Clock:\u003c\/strong\u003e NAD+ oscillates with NAMPT expression cycles. SIRT1 deacetylates BMAL1 and PER2 in NAD+-dependent manner.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNAD+\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e, \u003ca href=\"\/products\/glutathione-1500mg\"\u003eGlutathione\u003c\/a\u003e, and \u003ca href=\"\/products\/epithalon\"\u003eEpitalon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eLongevity Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"500","offer_id":60995752591690,"sku":"PBL-NAD-6G","price":69.99,"currency_code":"EUR","in_stock":true},{"title":"1000","offer_id":60995752624458,"sku":"PBL-NAD-6G","price":139.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-nad-plus-nicotinamide-adenine-dinucleotide-500mg-research-grade.webp?v=1773935010"},{"product_id":"ahk-cu","title":"AHK-CU","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAHK-Cu — Copper Tripeptide Analog for Dermatological and Follicular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAHK-Cu\u003c\/strong\u003e (Ala-His-Lys-Cu) is a copper-binding tripeptide analog structurally related to GHK-Cu, designed to investigate dermatological regeneration and hair follicle biology. This peptide-copper complex has demonstrated affinity for copper(II) ions and activity in stimulating dermal papilla cell proliferation in published in-vitro research. As a next-generation copper peptide, \u003cstrong\u003eAHK-Cu\u003c\/strong\u003e offers researchers a distinct molecular tool for studying extracellular matrix remodeling and follicular signaling pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAHK-Cu\u003c\/strong\u003e chelates copper(II) ions and delivers them to target cells, where copper serves as a cofactor for lysyl oxidase and other enzymes critical for collagen cross-linking and extracellular matrix assembly. Research published in the \u003cem\u003eJournal of Cosmetic Dermatology\u003c\/em\u003e has shown that AHK-Cu stimulates Wnt\/β-catenin signaling in dermal papilla cells, a pathway essential for hair follicle morphogenesis and cycling. Additionally, the peptide has been observed to upregulate VEGF expression, potentially enhancing perifollicular vascularization in tissue models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHair Follicle Biology:\u003c\/strong\u003e In-vitro studies using human dermal papilla cells have demonstrated that \u003cstrong\u003eAHK-Cu\u003c\/strong\u003e promotes cell proliferation and upregulates growth factors associated with the anagen (growth) phase of the hair cycle, including FGF-7 and VEGF.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollagen Synthesis:\u003c\/strong\u003e Copper peptide complexes including AHK-Cu have been investigated for their role in stimulating type I and type III collagen production in fibroblast cultures, with potential applications in wound healing and skin aging research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtracellular Matrix Remodeling:\u003c\/strong\u003e Research has examined how copper delivery via AHK-Cu modulates matrix metalloproteinase (MMP) activity, balancing tissue degradation and synthesis in skin equivalent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eScalp Microenvironment:\u003c\/strong\u003e Studies have explored AHK-Cu's effects on the perifollicular microenvironment, including its influence on stem cell niche signaling and inflammatory cytokine modulation in scalp tissue models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAHK-Cu\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying copper peptide biology and dermatological pathways may also find these compounds relevant: \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, \u003ca href=\"\/products\/snap-8\"\u003eSNAP-8\u003c\/a\u003e, and \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eDermatological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752657226,"sku":"PBL-AHK-CU-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ahk-cu-copper-tripeptide-50mg-research-grade.webp?v=1773935011"},{"product_id":"aod9604","title":"AOD9604","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAOD-9604 — Growth Hormone Fragment for Lipolytic Pathway Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAOD-9604\u003c\/strong\u003e is a modified 16-amino acid fragment (residues 177-191) of human growth hormone with an added N-terminal tyrosine. Developed at Monash University, it isolates GH lipolytic activity from growth-promoting and diabetogenic effects. Research in \u003cem\u003eObesity Research\u003c\/em\u003e (2001) showed it stimulates lipolysis and inhibits lipogenesis without affecting IGF-1 or insulin resistance.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eAOD-9604 activates beta-3 adrenergic receptor pathways, stimulating hormone-sensitive lipase (HSL) in adipocytes. It does not compete for GH receptor binding or stimulate IGF-1 secretion. Studies also showed stimulation of proteoglycan and collagen synthesis in chondrocyte models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipolysis \u0026amp; Adipocyte Biology:\u003c\/strong\u003e Stimulates lipolysis dose-dependently while inhibiting de novo lipogenesis in adipocyte cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Signaling Dissection:\u003c\/strong\u003e Enables study of GH lipolytic domain independently from somatotropic and diabetogenic pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCartilage Biology:\u003c\/strong\u003e Stimulates proteoglycan synthesis in bovine cartilage explants, investigated in osteoarthritis models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Pathway Analysis:\u003c\/strong\u003e Tool for investigating beta-3 adrenergic signaling, cAMP-PKA cascade, HSL and perilipin phosphorylation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAOD-9604\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752788298,"sku":"PBL-AOD9604-6G","price":64.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-aod-9604-fat-loss-peptide-5mg-research-grade.webp?v=1773935013"},{"product_id":"bpc-157-tb-500-ghk-cu-kvp","title":"BPC-157\/TB-500\/GHK-CU\/KVP","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eBPC-157 \/ TB-500 \/ GHK-Cu \/ KPV Quad Blend — Four-Peptide Formulation for Comprehensive Regenerative Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eQuad Blend\u003c\/strong\u003e is the most comprehensive multi-peptide formulation, adding KPV (α-MSH C-terminal tripeptide) for potent NF-κB pathway inhibition. Four-target approach from acute inflammatory modulation through complete tissue regeneration.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eBPC-157 drives VEGF angiogenesis. TB-500 promotes actin-mediated migration. GHK-Cu activates matrix enzymes and stem cell recruitment. KPV directly inhibits NF-κB nuclear translocation, suppressing IL-1β, IL-6, TNF-α and NLRP3 inflammasome — a mechanism not covered by the other three alone.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull-Spectrum Repair Model:\u003c\/strong\u003e Targets inflammation (KPV), angiogenesis (BPC-157), migration (TB-500), matrix remodeling (GHK-Cu) simultaneously.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNF-κB Pathway Integration:\u003c\/strong\u003e KPV's direct NF-κB inhibition complements anti-inflammatory effects of other components.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucosal and Dermal Models:\u003c\/strong\u003e Each component active in mucosal and dermal contexts — applicable to GI, cutaneous, and musculoskeletal research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergy Assessment:\u003c\/strong\u003e Stepwise dual→triple→quad formulations create a framework for assessing each component's contribution.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eBPC-157\/TB-500\/GHK-Cu\/KPV Quad Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/bpc-157-tb-500-ghk-cu-kvp\"\u003eBPC-157\/TB-500\/GHK-Cu\/KPV Quad Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157-tb-500-ghk-cu\"\u003eBPC-157\/TB-500\/GHK-Cu Triple Blend\u003c\/a\u003e, \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157-tb-500\"\u003eBPC-157 \u0026amp; TB-500 Blend\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/peptides-blend\"\u003ePeptide Blends\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752821066,"sku":"PBL-BPC-157TB-500GHK-CUKVP-6G","price":199.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-bpc-157-tb-500-ghk-cu-kpv-quad-blend-10mg-research-grade.webp?v=1773935015"},{"product_id":"bpc-157-tb-500-ghk-cu","title":"BPC-157\/TB-500\/GHK-CU","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eBPC-157 \/ TB-500 \/ GHK-Cu Triple Blend — Three-Peptide Combination for Advanced Regenerative Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eTriple Blend\u003c\/strong\u003e adds GHK-Cu (copper tripeptide) to the BPC-157\/TB-500 combination, introducing copper-dependent enzyme activation and ECM remodeling. Each component independently validated in peer-reviewed research. Investigates synergistic effects across angiogenesis, cell migration, collagen synthesis, and stem cell recruitment.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eBPC-157 activates VEGF and FAK-paxillin. TB-500 modulates actin polymerization. GHK-Cu delivers copper for lysyl oxidase, SOD, and stimulates 4,000+ genes. Three-target approach spans inflammation through neovascularization, migration, ECM assembly, and tissue maturation.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMulti-Target Regeneration:\u003c\/strong\u003e Simultaneous activation of angiogenic (BPC-157), migratory (TB-500), and matrix-remodeling (GHK-Cu) pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollagen Architecture:\u003c\/strong\u003e GHK-Cu uniquely contributes copper-dependent collagen cross-linking and matrix maturation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStem Cell Recruitment:\u003c\/strong\u003e GHK-Cu promotes MSC recruitment while BPC-157 enhances growth factor receptors — enhanced regenerative microenvironment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing Research:\u003c\/strong\u003e Each component independently demonstrated in wound closure, granulation, and scar quality models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eBPC-157\/TB-500\/GHK-Cu Triple Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/bpc-157-tb-500-ghk-cu\"\u003eBPC-157\/TB-500\/GHK-Cu Triple Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157-tb-500\"\u003eBPC-157 \u0026amp; TB-500 Blend\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157-tb-500-ghk-cu-kvp\"\u003eBPC-157\/TB-500\/GHK-Cu\/KPV Quad Blend\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/peptides-blend\"\u003ePeptide Blends\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752853834,"sku":"PBL-BPC-157TB-500GHK-CU-6G","price":159.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-bpc-157-tb-500-ghk-cu-triple-blend-10mg-research-grade.webp?v=1773935016"},{"product_id":"kisspeptin","title":"Kisspeptin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eKisspeptin-10 — KISS1R Agonist for Reproductive Neuroendocrinology Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKisspeptin-10\u003c\/strong\u003e is the C-terminal decapeptide of the KISS1 gene product, a critical HPG axis regulator. Identified as GPR54 ligand by de Roux et al. and Seminara et al. (2003, \u003cem\u003eNEJM\u003c\/em\u003e). Loss-of-function KISS1R mutations cause hypogonadotropic hypogonadism.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eKisspeptin-10 binds KISS1R (GPR54), a Gq\/11 receptor on GnRH neurons, triggering PLC-calcium mobilization and GnRH pulsatile secretion → LH and FSH release. Arcuate KNDy neurons generate the GnRH pulse essential for gonadotropin secretion.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGnRH Pulse Generator:\u003c\/strong\u003e Critical component of the GnRH pulse generator via arcuate KNDy neurons (kisspeptin + neurokinin B + dynorphin).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePuberty Research:\u003c\/strong\u003e Kisspeptin signaling increases dramatically at puberty — study neuroendocrine mechanisms of pubertal GnRH activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFertility and Ovulation:\u003c\/strong\u003e Triggers LH surges comparable to ovulation requirements, studying positive estrogen feedback on HPG axis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic-Reproductive Integration:\u003c\/strong\u003e Kisspeptin neurons receive leptin, insulin, and glucose inputs — nexus for energy-reproductive competence research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eKisspeptin-10\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/kisspeptin\"\u003eKisspeptin-10\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e, \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e, and \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eEndocrine Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752886602,"sku":"PBL-KISSPEPTIN-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-kisspeptin-reproductive-peptide-5mg-research-grade.webp?v=1773935018"},{"product_id":"cjc-1295-without-dac","title":"CJC 1295 without dac","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCJC-1295 Without DAC — Modified GHRH Analog for Pulsatile GH Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 Without DAC\u003c\/strong\u003e (Mod GRF 1-29) is a synthetic 29-amino acid GHRH analog with four substitutions (Ala2, Gln8, Ala15, Leu27) conferring DPP-IV resistance. Unlike the DAC version, it preserves natural pulsatile GH release, making it preferred for physiological GH secretion research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 Without DAC binds GHRH receptors on pituitary somatotrophs, activating the Gs-adenylyl cyclase-cAMP-PKA cascade for GH vesicle exocytosis. Half-life extended from ~7 min (native GRF 1-29) to 30+ min while maintaining pulsatile release kinetics essential for avoiding GH receptor desensitization.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulsatile GH Secretion:\u003c\/strong\u003e Stimulates somatotrophs without sustained elevation, preserving the ultradian rhythm of GH secretion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Secretagogue Research:\u003c\/strong\u003e Frequently combined with Ipamorelin — complementary GHRH + GHS-R pathways amplify GH release synergistically.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSomatotroph Cell Biology:\u003c\/strong\u003e Tool for investigating GHRH receptor signaling, cAMP response, and GH gene transcription.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDPP-IV Resistance Engineering:\u003c\/strong\u003e Model for studying how strategic amino acid substitutions extend peptide bioavailability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCJC-1295 Without DAC\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752984906,"sku":"PBL-CJC1295WITHOUTDAC-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cjc-1295-without-dac-growth-hormone-peptide-5mg-research-grade.webp?v=1773935019"},{"product_id":"ghk-cu","title":"GHK-CU","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHK-Cu — Copper Tripeptide Complex for Regenerative Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHK-Cu\u003c\/strong\u003e (Glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide identified in human plasma by Pickart \u0026amp; Thaler (1973). Over 60 peer-reviewed publications document its roles in wound healing, collagen synthesis, anti-inflammatory signaling, and stem cell recruitment.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eGHK-Cu delivers copper ions essential for lysyl oxidase, SOD, and tyrosinase. It upregulates ECM assembly genes while downregulating metalloproteinases. Genome-wide analysis (\u003cem\u003eGene\u003c\/em\u003e, 2014) revealed modulation of 4,000+ genes across tissue remodeling, inflammation, and antioxidant pathways.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing:\u003c\/strong\u003e Accelerates fibroblast migration and wound closure in scratch assay models. Enhanced granulation tissue and wound tensile strength in vivo.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollagen \u0026amp; ECM Biology:\u003c\/strong\u003e Stimulates type I\/III collagen, elastin, and proteoglycan synthesis while organizing collagen fibril architecture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory:\u003c\/strong\u003e Suppresses IL-6, TNF-α, TGF-β1 and reduces oxidative damage markers in tissue injury models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStem Cell Recruitment:\u003c\/strong\u003e Promotes recruitment and differentiation of mesenchymal stem cells for endogenous regenerative mechanisms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHK-Cu\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/snap-8\"\u003eSNAP-8\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eDermatological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"50","offer_id":60995753017674,"sku":"PBL-GHK-CU-6G","price":39.99,"currency_code":"EUR","in_stock":true},{"title":"100","offer_id":60995753050442,"sku":"PBL-GHK-CU-6G","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghk-cu-copper-peptide-50mg-research-grade.webp?v=1773933878"},{"product_id":"aicar","title":"Aicar","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAICAR — Cell-Permeable AMPK Activator for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAICAR\u003c\/strong\u003e (Acadesine) is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. First described by Corton et al. (1995), AICAR has become one of the most widely used pharmacological tools in metabolic research, spanning exercise physiology, glucose metabolism, and mitochondrial biogenesis.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eAICAR enters cells via adenosine transporters and is phosphorylated to ZMP, an AMP mimetic that binds the γ-subunit of AMPK, triggering allosteric activation. This shifts metabolism toward catabolic pathways — fatty acid oxidation, glucose uptake, mitochondrial biogenesis. Narkar et al. (2008, \u003cem\u003eCell\u003c\/em\u003e) showed AICAR increased running endurance by 44% in sedentary mice.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK Activation \u0026amp; Energy Sensing:\u003c\/strong\u003e Gold-standard pharmacological AMPK activator for studying energy depletion responses, mTOR suppression, and autophagy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Mimetic Research:\u003c\/strong\u003e Recapitulates molecular adaptations of endurance exercise: PGC-1α upregulation, mitochondrial biogenesis, slow-twitch fiber switching.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucose Metabolism:\u003c\/strong\u003e Increases GLUT4 translocation for insulin-independent glucose uptake in muscle cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipid Metabolism:\u003c\/strong\u003e Phosphorylates ACC, reducing malonyl-CoA and stimulating CPT1-dependent fatty acid oxidation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAICAR\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e, and \u003ca href=\"\/products\/slu-pp-322\"\u003eSLU-PP-332\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753083210,"sku":"PBL-AICAR-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-aicar-ampk-activator-50mg-research-grade.webp?v=1773935021"},{"product_id":"cjc-ipa","title":"CJC 1295 Without dac + Ipamorelin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCJC-1295 (No DAC) \u0026amp; Ipamorelin Blend — Dual-Pathway Growth Hormone Secretion Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eCJC-1295 \u0026amp; Ipamorelin Blend\u003c\/strong\u003e combines a GHRH receptor agonist with a GHS receptor agonist for synergistic GH release through dual receptor pathway activation. The most widely studied GH secretagogue pairing in preclinical research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 activates Gs-coupled GHRH receptors (cAMP\/PKA). Ipamorelin activates Gq-coupled GHS-R1a (PLC\/IP3\/calcium). Combined cAMP priming + calcium triggering produces GH pulses 3-10x greater than either alone. Ipamorelin's selectivity ensures no parallel cortisol\/prolactin increases.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic GH Release:\u003c\/strong\u003e Convergent intracellular signaling produces supraphysiological GH pulses — studies somatotroph secretory capacity limits.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulsatility Preservation:\u003c\/strong\u003e CJC-1295 No DAC preserves physiological pulsatile release; combined with Ipamorelin's clean profile amplifies natural pulse amplitude.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Axis Pharmacology:\u003c\/strong\u003e Model for simultaneous complementary receptor activation producing synergistic responses — broadly applicable endocrine pharmacology concept.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective Stimulation:\u003c\/strong\u003e Cleanest GH stimulation protocol available — isolated GH axis activation without cortisol or prolactin confounds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCJC-1295 \u0026amp; Ipamorelin Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/cjc-ipa\"\u003eCJC-1295 \u0026amp; Ipamorelin Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e, \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, and \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753115978,"sku":"PBL-CJC1295WITHOUTDACIPAMORELIN-6G","price":69.99,"currency_code":"EUR","in_stock":true},{"title":"20","offer_id":60995753148746,"sku":"PBL-CJC1295WITHOUTDACIPAMORELIN-6G","price":129.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cjc-1295-ipamorelin-growth-hormone-blend-10mg-research-grade.webp?v=1773935023"},{"product_id":"selank","title":"Selank","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSelank — Tuftsin-Derived Heptapeptide for Anxiolytic and Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSelank\u003c\/strong\u003e (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic tuftsin analog with Pro-Gly-Pro extension for stability. Developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Combined anxiolytic and nootropic properties without sedation or dependence.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSelank allosterically enhances GABA-A receptor sensitivity without direct benzodiazepine-site binding. Increases hippocampal BDNF mRNA. Stabilizes enkephalin levels by inhibiting enkephalinase. Modulates 36 genes related to GABAergic, serotonergic, and dopaminergic neurotransmission in the hippocampus.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGABAergic Modulation:\u003c\/strong\u003e Allosteric GABA-A enhancement providing anxiolytic effects without sedation, tolerance, or withdrawal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF and Neuroplasticity:\u003c\/strong\u003e Increased hippocampal BDNF with downstream TrkB-CREB signaling for LTP and memory consolidation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnkephalin Metabolism:\u003c\/strong\u003e Inhibits enkephalin-degrading enzymes for elevated endogenous opioid signaling without mu-agonism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune-Neuro Crosstalk:\u003c\/strong\u003e Retains tuftsin immunomodulatory properties (phagocytosis, IL-6) for studying nervous-immune bidirectional communication.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSelank\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e, and \u003ca href=\"\/products\/dsip\"\u003eDSIP\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753181514,"sku":"PBL-SELANK-6G","price":29.99,"currency_code":"EUR","in_stock":true},{"title":"30","offer_id":60995753214282,"sku":"PBL-SELANK-6G","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-selank-anxiolytic-nootropic-peptide-10mg-research-grade.webp?v=1773935024"},{"product_id":"mots-c","title":"MOTS-C","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMOTS-c — Mitochondrial-Derived Peptide for Metabolic Reprogramming Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMOTS-c\u003c\/strong\u003e is a 16-amino acid mitochondrial-encoded peptide discovered by Lee et al. at USC (\u003cem\u003eCell Metabolism\u003c\/em\u003e, 2015). One of the first mitochondrial-derived peptides (MDPs) with systemic signaling, representing a novel class of retrograde signaling molecules.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMOTS-c translocates to the nucleus under metabolic stress, regulating AMPK-dependent transcription. It inhibits the folate-methionine cycle through AICAR accumulation, mimicking caloric restriction. Circulating levels decline with age, correlating with metabolic dysfunction.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitohormesis \u0026amp; Retrograde Signaling:\u003c\/strong\u003e Paradigm of mitochondria-to-nucleus peptide communication coordinating metabolic adaptation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK Activation:\u003c\/strong\u003e Unique activation via folate cycle modulation — distinct from classical AMPK activators.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Physiology:\u003c\/strong\u003e Levels increase during exercise; enhances exercise capacity in aged mice, mediating metabolic benefits of activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Longevity:\u003c\/strong\u003e Declining levels correlate with aging; investigated for reversing insulin resistance and mitochondrial dysfunction.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMOTS-c\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753247050,"sku":"PBL-MOTS-C-10MG","price":49.99,"currency_code":"EUR","in_stock":true},{"title":"40","offer_id":60995753279818,"sku":"PBL-MOTS-C-10MG","price":179.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mots-c-mitochondrial-peptide-10mg-research-grade.webp?v=1773935026"},{"product_id":"semax","title":"Semax","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSemax — ACTH(4-10) Analog for Neurotrophic Factor and Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSemax\u003c\/strong\u003e (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic ACTH(4-10) analog developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Pro-Gly-Pro extension confers protease resistance without steroidogenic effects. Over 200 published studies on neurotrophic factor expression and cognitive performance.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSemax upregulates BDNF and TrkB in hippocampus and cortex, increases NGF expression, enhances 5-HT turnover, and activates the MAPK\/ERK cascade for neuronal survival under ischemic conditions.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF \u0026amp; NGF Upregulation:\u003c\/strong\u003e Sustained increases in hippocampal BDNF and cortical NGF — enhanced neurotrophic support documented across independent research groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement Models:\u003c\/strong\u003e Improved Morris water maze, passive avoidance, and novel object recognition correlating with increased LTP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Reduces infarct volume, preserves BBB integrity, maintains neuronal viability in stroke models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Profiling:\u003c\/strong\u003e Transcriptomic analysis reveals modulation of neurotransmitter, immune, vascular, and neuroprotection genes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSemax\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753312586,"sku":"PBL-SEMAX-10MG","price":29.99,"currency_code":"EUR","in_stock":true},{"title":"30","offer_id":60995753345354,"sku":"PBL-SEMAX-10MG","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-semax-nootropic-cognitive-peptide-10mg-research-grade.webp?v=1773935027"},{"product_id":"dsip","title":"DSIP","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eDSIP — Delta Sleep-Inducing Peptide for Neuroendocrine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDSIP\u003c\/strong\u003e (Delta Sleep-Inducing Peptide) is a 9-amino acid neuropeptide first isolated from rabbit cerebral venous blood during slow-wave sleep (Schoenenberger \u0026amp; Monnier, 1977). Functions as a broad-spectrum neuromodulator affecting sleep architecture, stress response, HPA axis regulation, and circadian rhythm modulation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eDSIP crosses the blood-brain barrier and interacts with GABAergic, serotonergic, and glutamatergic systems. It modulates cortisol and ACTH secretion, suppresses stress-induced corticotropin release, and influences endogenous opioid systems. Its sleep effects appear mediated through delta (0.5-4 Hz) EEG power enhancement.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSleep Architecture:\u003c\/strong\u003e Selectively enhances slow-wave (delta) sleep without affecting REM duration — targeted tool for non-REM sleep research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPA Axis Modulation:\u003c\/strong\u003e Attenuates stress-induced ACTH and cortisol release, normalizing dysregulated corticosterone rhythms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCircadian Rhythm Biology:\u003c\/strong\u003e Exhibits circadian variation in CSF concentration; investigated for synchronizing peripheral clocks and melatonin patterns.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuropeptide Interactions:\u003c\/strong\u003e Explored for interactions with endogenous opioid system, LHRH secretion, and somatostatin release.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eDSIP\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/dsip\"\u003eDSIP\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753378122,"sku":"PBL-DSIP-10MG","price":44.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-dsip-delta-sleep-inducing-peptide-5mg-research-grade.webp?v=1773935029"},{"product_id":"epithalon","title":"Epitalon","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eEpitalon — Synthetic Tetrapeptide for Telomerase and Longevity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEpitalon\u003c\/strong\u003e (Ala-Glu-Asp-Gly) is a synthetic analog of pineal epithalamin developed by Professor Vladimir Khavinson. Published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2003): telomerase reactivation in human somatic cells.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eEpitalon stimulates hTERT expression, the catalytic subunit of telomerase. Khavinson et al. demonstrated telomerase activation in human fetal fibroblasts extending proliferative capacity beyond the Hayflick limit. Also normalizes circadian melatonin secretion in aged models and modulates antioxidant enzymes (SOD, GPx).\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTelomere Biology:\u003c\/strong\u003e One of few peptides shown to activate telomerase in human somatic cells, extending replicative lifespan with maintained genomic stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePineal Gland Function:\u003c\/strong\u003e Restores nighttime melatonin peak and normalizes disrupted circadian rhythms in aged rodent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOxidative Stress:\u003c\/strong\u003e Increases SOD, catalase, GPx expression and reduces lipid peroxidation in aged tissues.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChromatin Remodeling:\u003c\/strong\u003e Short peptides interact with specific DNA sequences, influencing chromatin states and senescence-associated gene expression.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eEpitalon\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/epithalon\"\u003eEpitalon\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e, \u003ca href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e, and \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eLongevity Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753410890,"sku":"PBL-EPITALON-10MG","price":34.99,"currency_code":"EUR","in_stock":true},{"title":"50","offer_id":60995753443658,"sku":"PBL-EPITALON-10MG","price":154.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-epitalon-telomerase-activator-peptide-10mg-research-grade.webp?v=1773935031"},{"product_id":"ipamorelin","title":"Ipamorelin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eIpamorelin — Selective GH Secretagogue for Targeted Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIpamorelin\u003c\/strong\u003e is a synthetic pentapeptide GHS-R1a agonist distinguished by exceptional selectivity — stimulates GH without affecting cortisol, prolactin, or ACTH (Raun et al., \u003cem\u003epharmaceutical-grade Journal of Endocrinology\u003c\/em\u003e, 1998). The most specific GHS-R1a agonist available.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIpamorelin activates GHS-R1a with high affinity via PLC signaling. Minimal interaction with other hormone pathways. No tachyphylaxis over extended dosing. Clean pharmacological profile makes it the preferred secretagogue for isolated GH axis research.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective GH Release:\u003c\/strong\u003e Robust GH release without cortisol, ACTH, or prolactin increases — study GH-specific effects cleanly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Studies:\u003c\/strong\u003e Combined with CJC-1295 for complementary GHRH + GHS-R amplification exceeding either alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a Pharmacology:\u003c\/strong\u003e Reference compound for ghrelin receptor selectivity, biased agonism, and structural determinants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone Metabolism:\u003c\/strong\u003e Preclinical effects on osteoblast differentiation and BMD via direct GHS-R1a and indirect GH\/IGF-1 signaling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eIpamorelin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e, \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, and \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753509194,"sku":"PBL-IPAMORELIN-10MG","price":49.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ipamorelin-growth-hormone-secretagogue-5mg-research-grade.webp?v=1773935032"},{"product_id":"melanotan-ii","title":"Melanotan II","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMelanotan II — Cyclic Melanocortin Receptor Agonist for Pigmentation Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMelanotan II\u003c\/strong\u003e (MT-II) is a synthetic cyclic heptapeptide α-MSH analog designed by Hruby \u0026amp; Hadley at University of Arizona. Non-selective melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R) for pigmentation, energy homeostasis, and behavioral research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMT-II activates melanocortin receptors via Gs-cAMP signaling. At MC1R: cAMP-PKA-MITF-tyrosinase cascade for eumelanin synthesis. At MC4R: anorexigenic pathways and sexual arousal circuits. Induces melanogenesis independent of UV (\u003cem\u003ePeptides\u003c\/em\u003e, 1996). MC4R effects led to bremelanotide (PT-141) development.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanogenesis Research:\u003c\/strong\u003e Stimulates melanin production via MC1R-cAMP-MITF pathway for UV-independent pigmentation studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMC Receptor Pharmacology:\u003c\/strong\u003e Non-selective reference compound for studying melanocortin receptor subtypes and developing selective analogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy Homeostasis:\u003c\/strong\u003e MC3R\/MC4R activation modulates hypothalamic feeding circuits and leptin-melanocortin pathway interactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoprotection:\u003c\/strong\u003e Investigating melanocortin-stimulated melanogenesis for protective effects against UV-induced DNA damage.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMelanotan II\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e, \u003ca href=\"\/products\/snap-8\"\u003eSNAP-8\u003c\/a\u003e, and \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/anti-aging\"\u003eDermatological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753607498,"sku":"PBL-MELANOTANII-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-melanotan-ii-peptide-10mg-research-grade.webp?v=1773933887"},{"product_id":"tb-500","title":"TB-500","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eTB-500 — Thymosin Beta-4 Active Fragment for Actin Regulation and Tissue Repair Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTB-500\u003c\/strong\u003e (Thymosin Beta-4 Fragment) contains the active region of Tβ4, the primary G-actin sequestering molecule. Promotes cell migration, angiogenesis, and tissue repair. Expressed in virtually all cell types. Research by Goldstein et al. and Sosne et al.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eTB-500 promotes migration via the LKKTET motif, modulating actin polymerization. Upregulates Akt\/PI3K survival signaling, promotes VEGF-dependent and -independent angiogenesis. \u003cem\u003eNature\u003c\/em\u003e (2004) demonstrated functional cardiac regeneration via epicardial cell activation.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Migration and Wound Healing:\u003c\/strong\u003e Modulates actin dynamics and lamellipodium formation. Accelerated wound closure, enhanced granulation, improved remodeling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAngiogenesis Research:\u003c\/strong\u003e Promotes new vessel formation through VEGF pathways and direct endothelial cell migration in matrigel assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Regeneration:\u003c\/strong\u003e Landmark: Tβ4 activates epicardial progenitors post-MI, promoting neovascularization and functional recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory Mechanisms:\u003c\/strong\u003e Reduces NF-κB inflammatory gene expression with decreased neutrophil infiltration and pro-inflammatory cytokines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eTB-500\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery \u0026amp; Tissue Repair\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753640266,"sku":"PBL-TB-500-10MG","price":49.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-tb-500-thymosin-beta-4-peptide-10mg-research-grade.webp?v=1773933902"},{"product_id":"bpc-157","title":"BPC 157","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eBPC-157 — Gastric Pentadecapeptide for Tissue Repair and Cytoprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eBPC-157\u003c\/strong\u003e (Body Protection Compound-157) is a synthetic 15-amino acid peptide derived from human gastric juice. Characterized by Sikiric et al. at the University of Zagreb, it has over 100 published preclinical studies on tissue repair, angiogenesis, and cytoprotection. Notable for stability in acidic environments and broad biological activity across organ systems.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eBPC-157 modulates the NO system and upregulates VEGF, FGF-2, and EGF receptor signaling. It promotes angiogenesis via endothelial cell migration and tube formation (\u003cem\u003eCurrent Pharmaceutical Design\u003c\/em\u003e, 2018). It interacts with dopaminergic and serotonergic systems, and activates the FAK-paxillin pathway for fibroblast migration.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTendon and Ligament Research:\u003c\/strong\u003e Accelerates tendon-to-bone healing with improved collagen fiber organization and mechanical strength in rat models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal Cytoprotection:\u003c\/strong\u003e Protective effects against NSAID-induced lesions, ethanol damage, and surgical anastomosis complications.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAngiogenesis and Wound Healing:\u003c\/strong\u003e Stimulates blood vessel formation and granulation tissue development, accelerating wound closure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotective Pathways:\u003c\/strong\u003e Modulates neurotransmitter systems and protects against peripheral nerve crush injury.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eBPC-157\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery \u0026amp; Tissue Repair\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753673034,"sku":"PBL-BPC157-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-bpc-157-peptide-10mg-research-grade.webp?v=1773933875"},{"product_id":"pt-141","title":"PT 141","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePT-141 — Selective MC3R\/MC4R Agonist for Central Melanocortin Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePT-141\u003c\/strong\u003e (Bremelanotide) is a cyclic heptapeptide derived from Melanotan II via C-terminal carboxylation. Selective for MC3R\/MC4R over MC1R — minimal melanogenic activity while retaining CNS effects. Key tool for hypothalamic melanocortin signaling research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePT-141 activates MC4R\/MC3R in hypothalamic nuclei via Gs-cAMP signaling. Effects mediated through CNS pathways, not peripheral vascular mechanisms. MC4R activation triggers descending spinal projections to autonomic preganglionic neurons, modulating sympathetic and parasympathetic outflow.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMC4R Signaling:\u003c\/strong\u003e Selective tool for studying MC4R-mediated CNS signaling distinct from peripheral MC1R activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAutonomic Nervous System:\u003c\/strong\u003e Modulates autonomic outflow through hypothalamic-spinal pathways, studying central melanocortin regulation of peripheral function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanocortin Structure-Activity:\u003c\/strong\u003e Metabolite-derived analog showing how subtle modifications alter MC receptor subtype selectivity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrine Integration:\u003c\/strong\u003e MC4R neurons integrate leptin, insulin, and orexin inputs — studying converging hypothalamic pathways.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePT-141\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e, \u003ca href=\"\/products\/kisspeptin\"\u003eKisspeptin\u003c\/a\u003e, and \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753705802,"sku":"PBL-PT141-10MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pt-141-bremelanotide-peptide-10mg-research-grade.webp?v=1773933893"},{"product_id":"bpc-157-tb-500","title":"BPC 157 | TB 500","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eBPC-157 \u0026amp; TB-500 Blend — Dual-Peptide Combination for Synergistic Tissue Repair Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eBPC-157 \u0026amp; TB-500 Blend\u003c\/strong\u003e combines two of the most studied tissue repair peptides. BPC-157 is a gastric pentadecapeptide with angiogenic and cytoprotective properties. TB-500 is the primary G-actin sequestering peptide promoting cell migration and cytoskeletal reorganization. Complementary mechanisms for wound healing, angiogenesis, and inflammation resolution.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eBPC-157 activates VEGF and FAK-paxillin signaling. TB-500 modulates actin polymerization via the LKKTET motif. BPC-157 upregulates growth factor receptors (VEGFR2, EGF-R), potentially enhancing cellular response to TB-500's migratory signals. Together they address inflammation resolution, neovascularization, cell migration, and ECM remodeling.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComplementary Angiogenic Pathways:\u003c\/strong\u003e BPC-157 drives VEGF-dependent angiogenesis while TB-500 promotes endothelial migration — vessel formation at signaling and structural levels.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMulti-Phase Tissue Repair:\u003c\/strong\u003e Both peptides span inflammatory, proliferative, and remodeling phases. Studies potential synergistic effects across all repair phases.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTendon and Connective Tissue:\u003c\/strong\u003e Both independently demonstrate tendon healing effects. Combination investigates dual-pathway additive or synergistic improvements.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammatory Resolution:\u003c\/strong\u003e Both reduce NF-κB signaling and pro-inflammatory cytokines through distinct molecular mechanisms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eBPC-157 \u0026amp; TB-500 Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/bpc-157-tb-500\"\u003eBPC-157 \u0026amp; TB-500 Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157-tb-500-ghk-cu\"\u003eBPC-157\/TB-500\/GHK-Cu Triple Blend\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery \u0026amp; Tissue Repair\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753738570,"sku":"PBL-BPC157TB500-10MG","price":69.99,"currency_code":"EUR","in_stock":true},{"title":"20","offer_id":60995753771338,"sku":"PBL-BPC157TB500-10MG","price":129.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-bpc-157-tb-500-blend-peptide-10mg-research-grade.webp?v=1773933876"},{"product_id":"mt-1-melanotan-1","title":"MT-1 (Melanotan 1)","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMT-1 (Melanotan 1) — Alpha-MSH Analog for Dermatological and Photoprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMT-1 (Melanotan 1)\u003c\/strong\u003e, also known as Afamelanotide, is a synthetic tridecapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). First developed at the University of Arizona in the 1980s by Hruby and Hadley, this linear peptide binds with high selectivity to the melanocortin 1 receptor (MC1R), making it a valuable research tool for investigating melanogenesis, photoprotection pathways, and UV-induced DNA damage repair mechanisms. Unlike its cyclic counterpart Melanotan II, \u003cstrong\u003eMT-1\u003c\/strong\u003e demonstrates preferential MC1R selectivity with minimal cross-reactivity at MC3R, MC4R, and MC5R subtypes.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMelanotan 1\u003c\/strong\u003e activates the MC1R signaling cascade in melanocytes, stimulating adenylyl cyclase activity and increasing intracellular cAMP concentrations. This triggers CREB-mediated transcription of the MITF (microphthalmia-associated transcription factor) gene, which subsequently upregulates tyrosinase, TRP-1, and TRP-2 enzymes essential for eumelanin biosynthesis. Research published in \u003cem\u003eFASEB Journal\u003c\/em\u003e (2005) demonstrated that MC1R activation by α-MSH analogs also enhances nucleotide excision repair (NER) of cyclobutane pyrimidine dimers, independent of pigmentation effects, suggesting dual protective mechanisms against UV-induced mutagenesis.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanogenesis Pathways:\u003c\/strong\u003e In-vitro studies using human melanocyte cultures have demonstrated that \u003cstrong\u003eMT-1\u003c\/strong\u003e induces dose-dependent increases in eumelanin production through MC1R-cAMP-MITF signaling, providing researchers with a selective pharmacological tool for studying pigmentation biology.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoprotection Research:\u003c\/strong\u003e Published clinical studies in \u003cem\u003eThe New England Journal of Medicine\u003c\/em\u003e (2015) investigated MT-1 in the context of erythropoietic protoporphyria (EPP), demonstrating increased pain-free sun exposure duration and melanin density in treated subjects, establishing a model for photoprotective compound evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDNA Damage Repair:\u003c\/strong\u003e Research has shown that MC1R signaling activated by MT-1 enhances the repair of UV-induced DNA photoproducts through cAMP-dependent upregulation of XPC and DDB2 nucleotide excision repair proteins, independent of melanin production.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Biology Models:\u003c\/strong\u003e Investigators have utilized MT-1 in 3D skin equivalent models and organotypic cultures to study melanocyte-keratinocyte crosstalk, melanosome transfer dynamics, and the paracrine effects of melanocortin signaling on surrounding cell populations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMT-1 (Melanotan 1)\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mt-1-melanotan-1\"\u003eMT-1\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying melanocortin receptor signaling and dermatological pathways may also find these compounds relevant: \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e, \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/sexual-health\"\u003eSexual Health Research\u003c\/a\u003e and \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collections.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646465866,"sku":"PBL-MT1-10MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mt-1-melanotan-1-10mg-research-grade.webp?v=1774393539"},{"product_id":"na-selank-amidate","title":"NA Selank Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Selank Amidate — Stabilized Anxiolytic Neuropeptide for Cognitive and Immunomodulatory Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Selank Amidate\u003c\/strong\u003e is a modified analog of Selank, the synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been extensively studied for its anxiolytic, nootropic, and immunostimulatory properties. The N-acetyl amidate modification confers superior enzymatic stability by protecting both the N-terminal (via acetylation) and C-terminal (via amidation) from exopeptidase degradation, resulting in significantly enhanced bioavailability and prolonged biological activity in research applications.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e modulates the GABAergic system by allosterically influencing GABA-A receptor sensitivity, without directly binding the benzodiazepine site. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2008) demonstrated that Selank analogs increase BDNF (brain-derived neurotrophic factor) mRNA expression in the hippocampus and frontal cortex, promoting neuroplasticity. Additionally, the compound has been shown to modulate the expression of IL-6, IL-10, and TNF-α, suggesting dual neuroimmune regulatory activity. The stabilized form enhances these effects by maintaining effective concentrations over extended experimental timeframes.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnxiolytic Mechanisms:\u003c\/strong\u003e In behavioral models (elevated plus maze, open field test), \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e has demonstrated anxiolytic effects comparable to benzodiazepines without sedation, motor impairment, or dependence potential. Studies in \u003cem\u003eBehavioural Brain Research\u003c\/em\u003e (2009) documented significant reductions in anxiety-like behavior in rodent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Research has shown that Selank analogs enhance memory consolidation and retrieval in passive avoidance and Morris water maze paradigms, mediated through increased BDNF expression and enhanced monoamine neurotransmitter metabolism in hippocampal and prefrontal regions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e As a tuftsin analog, NA Selank Amidate stimulates phagocytic activity and modulates cytokine profiles. Published studies have documented increased natural killer cell activity and balanced Th1\/Th2 immune responses in treated animal models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Investigators have examined the compound's ability to protect neurons from oxidative stress-induced apoptosis, with evidence of enhanced SOD activity and reduced lipid peroxidation markers in cortical neuron cultures following treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-selank-amidate\"\u003eNA Selank Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying anxiolytic neuropeptides and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646629706,"sku":"PBL-NA-SELANK-AMIDATE-30MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-selank-amidate-30mg-research-grade.webp?v=1774393541"},{"product_id":"na-semax-amidate","title":"NA Semax Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Semax Amidate — Enhanced ACTH Analog for Neurotrophic and Cerebrovascular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Semax Amidate\u003c\/strong\u003e is a stabilized derivative of Semax, the synthetic heptapeptide analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied extensively for its pronounced neurotrophic, neuroprotective, and cognitive-enhancing properties. The N-acetyl amidate modification significantly increases the peptide's resistance to aminopeptidase and carboxypeptidase degradation, resulting in an extended half-life and enhanced potency compared to the parent compound in research settings.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e exerts its effects through multiple converging pathways. Research published in \u003cem\u003eNeuroscience Letters\u003c\/em\u003e (2006) demonstrated that Semax analogs rapidly upregulate BDNF and NGF (nerve growth factor) expression in cortical and hippocampal tissues through TrkB receptor-mediated signaling cascades. The compound also modulates dopaminergic and serotoninergic neurotransmission, increasing dopamine and serotonin turnover in the striatum and nucleus accumbens. Additionally, published data in \u003cem\u003eDoklady Biological Sciences\u003c\/em\u003e have shown that Semax analogs influence gene expression patterns related to neurovascular coupling and cerebral blood flow autoregulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotrophic Factor Expression:\u003c\/strong\u003e In-vitro and in-vivo studies have demonstrated that \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e upregulates BDNF, NGF, and NT-3 expression in glial and neuronal cell populations. Research in \u003cem\u003eBrain Research\u003c\/em\u003e (2007) documented a 2-3 fold increase in BDNF mRNA levels in the hippocampus following administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Performance:\u003c\/strong\u003e Behavioral studies using novel object recognition, radial arm maze, and contextual fear conditioning paradigms have shown significant enhancements in learning acquisition and memory retention in rodent models treated with Semax analogs, with the stabilized form demonstrating prolonged effect duration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCerebrovascular Research:\u003c\/strong\u003e Investigators have studied the compound's effects on cerebral hemodynamics, documenting improved cerebral blood flow autoregulation and reduced infarct volume in models of focal cerebral ischemia, mediated through NO-dependent vasodilation and neurovascular unit protection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroinflammation:\u003c\/strong\u003e Research has demonstrated that NA Semax Amidate modulates microglial activation states, promoting the M2 anti-inflammatory phenotype while attenuating pro-inflammatory cytokine release (IL-1β, TNF-α) in lipopolysaccharide-challenged neuronal co-cultures.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-semax-amidate\"\u003eNA Semax Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying neurotrophic signaling and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646793546,"sku":"PBL-NA-SEMAX-AMIDATE-30MG","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-semax-amidate-30mg-research-grade.webp?v=1774393542"},{"product_id":"ghrp-2","title":"GHRP-2","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHRP-2 — Growth Hormone Releasing Hexapeptide for Endocrine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHRP-2\u003c\/strong\u003e (Growth Hormone Releasing Peptide 2), also designated as Pralmorelin, is a synthetic hexapeptide (D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂) that acts as a potent agonist of the growth hormone secretagogue receptor (GHS-R1a), commonly known as the ghrelin receptor. Developed through systematic structure-activity relationship studies by Bowers et al. in the early 1990s, \u003cstrong\u003eGHRP-2\u003c\/strong\u003e is considered one of the most potent members of the GHRP family and serves as a critical pharmacological tool for investigating the somatotropic axis, ghrelin receptor biology, and pulsatile growth hormone secretion patterns.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eGHRP-2\u003c\/strong\u003e binds to the GHS-R1a receptor on somatotroph cells of the anterior pituitary, activating phospholipase C through Gq\/11 signaling and triggering IP3-mediated calcium release from intracellular stores. This calcium mobilization stimulates the exocytosis of GH-containing secretory vesicles. Published research in \u003cem\u003eEndocrine Reviews\u003c\/em\u003e (1999) demonstrated that GHRP-2 acts synergistically with GHRH by recruiting additional somatotrophs and amplifying the secretory burst amplitude. Notably, GHRP-2 also suppresses somatostatin release from hypothalamic neurons, further disinhibiting GH secretion through a complementary mechanism.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Hormone Secretion:\u003c\/strong\u003e \u003cstrong\u003eGHRP-2\u003c\/strong\u003e is among the most potent GH secretagogues characterized, producing dose-dependent GH release with peak plasma concentrations within 15-30 minutes. Comparative studies have shown GHRP-2 elicits greater GH responses than GHRP-6 at equivalent doses, making it an ideal tool for studying somatotroph function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS Receptor Pharmacology:\u003c\/strong\u003e As a high-affinity GHS-R1a agonist, GHRP-2 has been instrumental in characterizing receptor desensitization kinetics, internalization dynamics, and the biased agonism that differentiates synthetic GHS ligands from endogenous ghrelin signaling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppetite and Metabolic Regulation:\u003c\/strong\u003e Through its action on GHS-R1a receptors expressed in the arcuate nucleus, GHRP-2 influences NPY\/AgRP neuronal populations and modulates feeding behavior in rodent models, providing insights into the orexigenic pathways linking GH secretagogue signaling to energy homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePituitary Reserve Testing:\u003c\/strong\u003e Researchers have utilized GHRP-2 as a diagnostic challenge agent in clinical studies published in \u003cem\u003eEuropean Journal of Endocrinology\u003c\/em\u003e to evaluate GH secretory capacity and distinguish between hypothalamic and pituitary causes of GH deficiency.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHRP-2\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghrp-2\"\u003eGHRP-2\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying GH secretagogue receptor biology may also find these compounds relevant: \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, and \u003ca href=\"\/products\/cjc-1295-no-dac\"\u003eCJC-1295 No DAC\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646957386,"sku":"PBL-GHRP2-5MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghrp-2-peptide-5mg-research-grade.webp?v=1774393544"},{"product_id":"cjc-1295-with-dac","title":"CJC-1295 With DAC","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCJC-1295 With DAC — Long-Acting GHRH Analog for Sustained GH Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e (Drug Affinity Complex) is a synthetic 30-amino acid peptide analog of growth hormone-releasing hormone (GHRH) conjugated to a maleimidopropionic acid–lysine linker that covalently binds to circulating albumin in vivo. Originally developed by ConjuChem Biotechnologies, this modification dramatically extends the compound's half-life from approximately 30 minutes (native GHRH) to 6–8 days, enabling sustained elevation of growth hormone and IGF-1 levels over prolonged periods. This pharmacokinetic profile makes \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e an essential tool for researchers studying chronic versus pulsatile somatotropic axis stimulation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e binds to the GHRH receptor (GHRH-R) on anterior pituitary somatotrophs, activating Gs-protein–coupled adenylyl cyclase signaling and elevating intracellular cAMP. This triggers PKA-dependent phosphorylation of CREB and subsequent transcription of the GH1 gene, promoting both GH synthesis and secretion. The DAC bioconjugation technology enables covalent binding to serum albumin (Lys-34), protecting the peptide from DPP-IV degradation and renal clearance. Published research in \u003cem\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism\u003c\/em\u003e (2006) demonstrated sustained GH elevation for 6+ days following a single dose, with 1.5–3 fold increases in mean IGF-1 concentrations.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSustained GH Elevation:\u003c\/strong\u003e Unlike pulsatile GH secretagogues, \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e produces continuous GH elevation, enabling researchers to compare chronic versus episodic somatotropic stimulation and their differential effects on IGF-1 generation, body composition, and tissue-specific gene expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 Axis Research:\u003c\/strong\u003e Studies have documented dose-dependent increases in circulating IGF-1 and IGFBP-3 levels sustained over 7–14 day periods, providing a unique model for studying prolonged IGF-1 signaling and its downstream metabolic effects in various tissue types.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBody Composition Studies:\u003c\/strong\u003e Preclinical research has demonstrated that chronic GHRH-R activation via CJC-1295 DAC leads to measurable changes in lean mass accretion and adipose tissue reduction, with investigators examining the interplay between sustained GH signaling and lipid metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic Modeling:\u003c\/strong\u003e The DAC bioconjugation technology has been studied as a platform for extending the half-life of therapeutic peptides, with CJC-1295 serving as a proof-of-concept model for albumin-binding prodrug strategies published in \u003cem\u003eBioconjugate Chemistry\u003c\/em\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/cjc-1295-with-dac\"\u003eCJC-1295 with DAC\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying GHRH receptor pharmacology may also find these compounds relevant: \u003ca href=\"\/products\/cjc-1295-no-dac\"\u003eCJC-1295 No DAC\u003c\/a\u003e, \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, and \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647088458,"sku":"PBL-CJC1295-DAC-2MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cjc-1295-with-dac-2mg-research-grade.webp?v=1774393546"},{"product_id":"tb-500-fragment","title":"TB-500 Fragment","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eTB-500 Fragment — Active Core Sequence of Thymosin Beta-4 for Targeted Tissue Repair Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e is a synthetic peptide corresponding to the active region (amino acids 17-23, Ac-SDKP) of Thymosin Beta-4 (Tβ4), a 43-amino acid polypeptide originally isolated from the thymus gland. While full-length TB-500 has been widely studied for its tissue repair and anti-inflammatory properties, this fragment isolates the minimum pharmacophoric sequence responsible for the compound's principal biological activities: actin sequestration, cell migration promotion, and anti-fibrotic signaling. This targeted fragment allows researchers to investigate structure-activity relationships within the Tβ4 sequence with greater molecular precision.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eThe \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e retains the core Ac-SDKP tetrapeptide motif that interacts with G-actin monomers, modulating actin polymerization dynamics. By sequestering G-actin, the fragment influences lamellipodia formation and directional cell migration. Published studies in \u003cem\u003eAnnals of the New York Academy of Sciences\u003c\/em\u003e have demonstrated that this active sequence promotes endothelial cell migration and tubulogenesis through upregulation of VEGF and Ang-1 expression. Additionally, Ac-SDKP has been shown to inhibit TGF-β\/Smad signaling, reducing collagen I and III deposition by activated fibroblasts, which underlies its anti-fibrotic properties observed in preclinical cardiac and renal fibrosis models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Repair Mechanisms:\u003c\/strong\u003e Researchers have utilized \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e to study the minimal structural requirements for Tβ4-mediated tissue repair, demonstrating that the Ac-SDKP core sequence is sufficient to promote keratinocyte and fibroblast migration in wound healing assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Fibrotic Pathways:\u003c\/strong\u003e Published studies in \u003cem\u003eKidney International\u003c\/em\u003e have shown that Ac-SDKP inhibits renal fibrosis progression by suppressing TGF-β1\/Smad3 signaling and reducing α-SMA expression in myofibroblasts, establishing a model for anti-fibrotic compound evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAngiogenesis Research:\u003c\/strong\u003e The fragment has been studied in chorioallantoic membrane (CAM) and Matrigel plug assays, demonstrating pro-angiogenic activity through enhanced endothelial cell proliferation, migration, and capillary network formation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Injury Models:\u003c\/strong\u003e Investigators have examined TB-500 Fragment's effects in murine myocardial infarction models, documenting reduced scar formation and improved cardiac function parameters, with mechanism studies pointing to both anti-inflammatory and pro-survival signaling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/tb-500-fragment\"\u003eTB-500 Fragment\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying tissue repair and regenerative pathways may also find these compounds relevant: \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647121226,"sku":"PBL-TB500-FRAG-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-tb-500-fragment-10mg-research-grade.webp?v=1774393548"},{"product_id":"mgf-mechano-growth-factor","title":"MGF (Mechano Growth Factor)","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMGF (Mechano Growth Factor) — Splice Variant of IGF-1 for Muscle Biology and Regeneration Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMGF (Mechano Growth Factor)\u003c\/strong\u003e is a splice variant of the Insulin-like Growth Factor 1 (IGF-1) gene, specifically the IGF-1Ec isoform in humans (IGF-1Eb in rodents). Unlike the systemic IGF-1Ea isoform that is primarily hepatic in origin, MGF is produced locally within mechanically stressed skeletal muscle tissue and is characterized by a unique 24-amino acid C-terminal E-domain extension. First described by Goldspink et al. at University College London, \u003cstrong\u003eMGF\u003c\/strong\u003e has been shown to activate satellite cells (muscle stem cells) and initiate muscle repair cascades, making it an indispensable tool for researchers studying exercise physiology, muscle regeneration, and mechano-transduction pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMGF\u003c\/strong\u003e exerts its biological effects primarily through its unique E-domain peptide, which is distinct from the mature IGF-1 receptor-binding domain. Research published in \u003cem\u003eJournal of Physiology\u003c\/em\u003e (2003) demonstrated that the MGF E-domain activates satellite cells by stimulating their proliferation without promoting differentiation — a critical distinction from mature IGF-1, which drives terminal differentiation. This activation involves upregulation of MyoD and Myf5 transcription factors while suppressing myogenin expression. Additionally, MGF has been shown to activate the Akt\/mTOR pathway in an IGF-1R-independent manner, suggesting a distinct signaling mechanism through a putative E-domain receptor.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSatellite Cell Activation:\u003c\/strong\u003e In-vitro studies using primary myoblast cultures have demonstrated that \u003cstrong\u003eMGF\u003c\/strong\u003e promotes satellite cell proliferation at significantly lower concentrations than mature IGF-1, with the E-domain peptide alone sufficient to drive this mitogenic effect, enabling researchers to dissect the specific contribution of mechano-sensitive IGF-1 splicing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Damage and Repair:\u003c\/strong\u003e Preclinical models of exercise-induced and toxin-induced muscle damage have shown that MGF expression peaks within 24 hours of injury, preceding IGF-1Ea upregulation. Exogenous MGF administration has been observed to accelerate the regenerative timeline in cardiotoxin-injured murine muscle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechano-Transduction:\u003c\/strong\u003e Researchers have used MGF as a marker and effector to study how mechanical loading signals are transduced into molecular repair responses, with evidence that MGF expression is regulated by the calcineurin\/NFAT and p38 MAPK signaling cascades.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Muscle Decline:\u003c\/strong\u003e Studies have documented diminished MGF splicing efficiency in aged muscle tissue, suggesting impaired mechano-sensitive IGF-1 processing may contribute to sarcopenia, providing a model system for studying age-related muscle wasting.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMGF\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mgf-mechano-growth-factor\"\u003eMGF\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying IGF-1 signaling and muscle biology may also find these compounds relevant: \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/muscle-building\"\u003eMuscle Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647252298,"sku":"PBL-MGF-2MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mgf-mechano-growth-factor-2mg-research-grade.webp?v=1774393550"},{"product_id":"hexarelin","title":"Hexarelin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eHexarelin — Potent Hexapeptide GH Secretagogue for Cardiac and Endocrine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHexarelin\u003c\/strong\u003e (Examorelin, His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH₂) is a synthetic hexapeptide growth hormone secretagogue that acts as a potent agonist of the GHS-R1a (ghrelin) receptor. Developed from the early GHRP series, Hexarelin distinguishes itself through its superior potency and unique dual activity profile: in addition to robust GH release from pituitary somatotrophs, it demonstrates significant cardioprotective effects mediated through both GHS-R1a-dependent and independent pathways. These properties, extensively documented by Ghigo et al. at the University of Turin, make \u003cstrong\u003eHexarelin\u003c\/strong\u003e a versatile research tool spanning endocrine, cardiovascular, and neuroprotective research domains.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHexarelin\u003c\/strong\u003e activates GHS-R1a receptors on anterior pituitary somatotrophs, triggering Gq\/11-mediated phospholipase C activation, IP3-dependent calcium mobilization, and subsequent GH exocytosis. Its GH-releasing potency exceeds that of GHRP-6 by approximately 1.5-fold on a molar basis. Uniquely, research published in \u003cem\u003eEndocrinology\u003c\/em\u003e (2000) identified that Hexarelin also binds CD36 (scavenger receptor class B), a mechanism that mediates its cardioprotective effects independently of GH secretion. This CD36-dependent pathway promotes fatty acid uptake, reduces foam cell formation, and activates PPARγ signaling in cardiac tissue.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Hormone Secretion:\u003c\/strong\u003e \u003cstrong\u003eHexarelin\u003c\/strong\u003e produces robust, dose-dependent GH release that is amplified when co-administered with GHRH. Studies in \u003cem\u003eEuropean Journal of Endocrinology\u003c\/em\u003e have characterized its secretory kinetics, desensitization profile, and utility as a provocative test agent for GH reserve assessment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardioprotection:\u003c\/strong\u003e Published research in \u003cem\u003eCardiovascular Research\u003c\/em\u003e (2003) demonstrated that Hexarelin reduces infarct size and improves post-ischemic cardiac function in Langendorff heart models, with effects mediated through CD36-dependent activation of PPARγ and suppression of NF-κB inflammatory signaling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Atherosclerotic Mechanisms:\u003c\/strong\u003e Through its CD36 binding activity, Hexarelin has been shown to modulate macrophage cholesterol efflux and inhibit oxidized LDL uptake, providing researchers with a unique pharmacological probe for studying scavenger receptor biology in atherosclerosis models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotective Research:\u003c\/strong\u003e Investigators have documented that Hexarelin protects hippocampal neurons from glutamate-induced excitotoxicity in vitro, with evidence suggesting both GHS-R1a-dependent and independent neuroprotective mechanisms involving PI3K\/Akt survival signaling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eHexarelin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/hexarelin\"\u003eHexarelin\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying GH secretagogues and cardiovascular peptide biology may also find these compounds relevant: \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, \u003ca href=\"\/products\/ghrp-2\"\u003eGHRP-2\u003c\/a\u003e, and \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647383370,"sku":"PBL-HEXARELIN-5MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-hexarelin-peptide-5mg-research-grade.webp?v=1774393551"},{"product_id":"ghk-basic","title":"GHK Basic","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHK Basic — Tripeptide Growth Factor for Regenerative and Anti-Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHK (Glycyl-L-Histidyl-L-Lysine)\u003c\/strong\u003e is a naturally occurring human tripeptide first identified by Pickart and Thaler in 1973 from human plasma. This simple three-amino acid sequence (Gly-His-Lys) was discovered through its ability to cause aged human liver tissue to synthesize proteins characteristic of younger tissue. Unlike its copper-bound form GHK-Cu, \u003cstrong\u003eGHK Basic\u003c\/strong\u003e is supplied without the copper ion, allowing researchers to control the metallopeptide chemistry of their experimental systems. GHK naturally chelates copper(II) with high affinity (log K = 16.44) and will readily form the GHK-Cu complex when copper is present, making this format ideal for studies requiring precise control over copper delivery and speciation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eGHK\u003c\/strong\u003e exerts broad biological effects through multiple mechanisms. Genomic studies published in \u003cem\u003eJournal of Biomedicine and Biotechnology\u003c\/em\u003e (2012) by Pickart et al. revealed that GHK modulates the expression of over 4,000 human genes, resetting gene expression patterns from aged profiles toward youthful configurations. Key pathways include upregulation of collagen synthesis genes (COL1A1, COL3A1), tissue inhibitors of metalloproteinases (TIMPs), and antioxidant response elements (Nrf2 pathway). GHK also stimulates decorin expression, which serves as a natural TGF-β trap, helping regulate fibrosis and tissue remodeling. Its copper-chelating function additionally supports the activity of copper-dependent enzymes including superoxide dismutase (SOD) and lysyl oxidase.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Reprogramming:\u003c\/strong\u003e Comprehensive microarray analyses have demonstrated that \u003cstrong\u003eGHK\u003c\/strong\u003e resets the expression of DNA repair genes, antioxidant genes, and stem cell-related genes toward patterns observed in younger tissues, providing a powerful model for studying the molecular mechanisms of tissue aging and rejuvenation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtracellular Matrix Biology:\u003c\/strong\u003e GHK has been shown to stimulate collagen, elastin, and glycosaminoglycan synthesis in fibroblast cultures while simultaneously enhancing the breakdown of large, cross-linked collagen aggregates through controlled MMP regulation, promoting organized tissue remodeling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetal Ion Biochemistry:\u003c\/strong\u003e The GHK Basic format enables researchers to study copper(II) chelation kinetics, metallopeptide formation constants, and the differential biological activity of apo-GHK versus holo-GHK-Cu complexes in controlled experimental settings.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing Models:\u003c\/strong\u003e Published studies have documented accelerated wound closure, enhanced angiogenesis, and improved tensile strength in dermal wound models treated with GHK, mediated through coordinated upregulation of growth factors including VEGF, FGF-2, and TGF-β1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHK Basic\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghk-basic\"\u003eGHK Basic\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying copper peptide biology and tissue regeneration may also find these compounds relevant: \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420648169802,"sku":"PBL-GHK-BASIC-50MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghk-basic-peptide-50mg-research-grade.webp?v=1774393553"},{"product_id":"thymalin","title":"Thymalin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eThymalin — Thymic Bioregulatory Peptide for Immunomodulation and Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eThymalin\u003c\/strong\u003e (also known as Thymaline) is a polypeptide complex originally isolated from the thymus gland, developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. As one of the foundational compounds in the Khavinson bioregulatory peptide paradigm, Thymalin has been the subject of over 40 years of research, with more than 100 published studies documenting its immunomodulatory and geroprotective properties. The compound acts on thymic epithelial cells and T-lymphocyte precursors, restoring immune function parameters that decline with age-related thymic involution.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eThymalin\u003c\/strong\u003e acts on the neuroendocrine-immune regulatory axis by modulating thymic microenvironment signaling. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has demonstrated that Thymalin restores the balance between T-helper and T-suppressor lymphocyte populations, normalizes IL-2 receptor expression on T-cells, and stimulates thymulin (FTS) secretion from thymic epithelial cells. The compound also modulates the hypothalamic-pituitary-thymic axis, with studies showing restoration of melatonin and cortisol circadian rhythmicity in aged animal models. Additionally, Khavinson's research published in \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e demonstrated that Thymalin influences telomerase activity in immune cells, potentially counteracting replicative senescence in the lymphocyte compartment.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune Restoration:\u003c\/strong\u003e Clinical studies involving over 300 participants published by Khavinson and colleagues demonstrated that \u003cstrong\u003eThymalin\u003c\/strong\u003e administration restored T-cell immunity indices in elderly subjects, normalizing CD4\/CD8 ratios and enhancing natural killer cell cytotoxicity, establishing it as a reference compound for immune aging research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGeroprotection:\u003c\/strong\u003e A landmark 15-year observational study published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2003) documented a 28% reduction in cardiovascular mortality and a 2.0-fold reduction in overall mortality rate in elderly patients who received periodic Thymalin and Epithalon treatment courses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThymic Involution:\u003c\/strong\u003e Researchers have utilized Thymalin to study the mechanisms of age-related thymic atrophy, demonstrating partial reversal of thymic involution markers including restoration of cortical-medullary architecture and thymocyte populations in aged rodent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroimmune Crosstalk:\u003c\/strong\u003e Published studies have examined how Thymalin modulates the bidirectional communication between the immune and nervous systems, documenting effects on pineal melatonin synthesis, cortisol rhythmicity, and neuropeptide expression patterns in hypothalamic nuclei.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eThymalin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying bioregulatory peptides and immunomodulation may also find these compounds relevant: \u003ca href=\"\/products\/epithalon\"\u003eEpithalon\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420648366410,"sku":"PBL-THYMALIN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-thymalin-peptide-10mg-research-grade.webp?v=1774393555"},{"product_id":"foxo4-dri","title":"FOXO4-DRI","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eFOXO4-DRI — Senolytic Peptide for Cellular Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors in senescent cells. First described by Baar et al. (2017) in \u003cem\u003eCell\u003c\/em\u003e, this peptide selectively induces apoptosis in senescent cells by preventing FOXO4-mediated nuclear exclusion of p53, thereby restoring the cell's ability to undergo programmed cell death. As a targeted senolytic agent, \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e has become a pivotal research tool in the study of cellular senescence and age-related tissue dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e is engineered as a D-amino acid retro-inverso peptide, conferring exceptional proteolytic stability compared to native L-peptide sequences. In senescent cells, FOXO4 sequesters p53 in the nucleus through direct protein-protein interaction, preventing apoptotic signaling. FOXO4-DRI competitively binds FOXO4, disrupting this complex and allowing p53 to translocate to mitochondria, where it triggers caspase-dependent apoptosis. Crucially, this mechanism is selective for senescent cells—non-senescent cells with low FOXO4 expression remain unaffected.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular Senescence:\u003c\/strong\u003e Landmark research demonstrated that \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e selectively eliminates senescent cells in aged murine models, resulting in restoration of fur density, renal function, and physical performance parameters including running wheel activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSenescence-Associated Secretory Phenotype (SASP):\u003c\/strong\u003e By clearing senescent cells, FOXO4-DRI reduces the pro-inflammatory SASP milieu, which has been implicated in chronic tissue inflammation and age-related pathology progression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemotherapy-Induced Senescence:\u003c\/strong\u003e Preclinical models have demonstrated that FOXO4-DRI can mitigate doxorubicin-induced cellular senescence, a significant contributor to chemotherapy side effects and long-term tissue damage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Regeneration:\u003c\/strong\u003e Researchers have observed enhanced tissue repair capacity following senescent cell clearance, particularly in hepatic, renal, and dermal tissue models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide Type:\u003c\/strong\u003e D-retro-inverso modified peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/foxo4-dri\"\u003eFOXO4-DRI\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying senescence and aging pathways may also find these compounds relevant: \u003ca href=\"\/products\/epitalon\"\u003eEpitalon\u003c\/a\u003e, \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737364298,"sku":"PBL-FOXO4DRI-5MG","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-foxo4-dri-peptide-5mg-research-grade.webp?v=1774393557"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/collections\/peptides-biolab-bpc-157-peptide-10mg-research-grade_7e9a2590-70b8-48d4-891f-56a49d7fa101.webp?v=1774382724","url":"https:\/\/peptides-biolab.com\/collections\/all-peptides.oembed?page=2","provider":"Peptides BioLab","version":"1.0","type":"link"}