{"title":"Cognitive Function","description":"\u003cp\u003eOur cognitive function collection includes nootropic peptides studied for neuroprotection, neurogenesis, and cognitive enhancement. All peptides are research-grade with verified ≥98% purity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Compounds\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSemax\u003c\/strong\u003e - ACTH analog studied for cognitive enhancement, neuroprotection, and BDNF modulation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelank\u003c\/strong\u003e - Anxiolytic peptide researched for stress reduction and cognitive function\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDihexa\u003c\/strong\u003e - HGF\/c-Met agonist investigated for neurogenesis and cognitive restoration\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePinealon\u003c\/strong\u003e - Brain-targeting bioregulator peptide studied for neuroprotection\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNeurotransmitter modulation and synaptic plasticity\u003c\/li\u003e\n\u003cli\u003eBDNF (Brain-Derived Neurotrophic Factor) upregulation\u003c\/li\u003e\n\u003cli\u003eNeuroprotection and cognitive resilience\u003c\/li\u003e\n\u003cli\u003eMemory formation and recall\u003c\/li\u003e\n\u003cli\u003eAnxiety and stress response\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cstrong\u003eQuality Assurance:\u003c\/strong\u003e All Peptides BioLab nootropic peptides are synthesized for research use only, tested to ≥98% purity (HPLC), and supplied with batch-specific Certificates of Analysis. Not for human consumption.\u003c\/p\u003e","products":[{"product_id":"semax-selank","title":"Semax\/Selank","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSemax \/ Selank Nootropic Blend — Dual-Peptide Combination for Cognitive and Neuromodulatory Research\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eSemax \/ Selank Blend\u003c\/strong\u003e combines two complementary neuropeptides. Semax (ACTH 4-10 analog) upregulates BDNF\/NGF and monoaminergic transmission. Selank (tuftsin analog) modulates GABAergic tone and enkephalin metabolism. Dual-mechanism for cognitive enhancement and stress resilience.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSemax increases BDNF\/NGF through MAPK\/ERK, enhances 5-HT and DA transmission. Selank allosterically enhances GABA-A, inhibits enkephalinase, modulates 36 hippocampal genes. Semax enhances performance while Selank reduces anxiety without sedation — cognitive enhancement under reduced stress reactivity.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComplementary Neurochemistry:\u003c\/strong\u003e Semax enhances excitatory neurotrophic pathways while Selank strengthens inhibitory tone — balanced excitation\/inhibition for cognitive outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF and GABAergic Integration:\u003c\/strong\u003e Simultaneous BDNF upregulation (LTP\/plasticity) and GABA enhancement (signal-to-noise refinement) — optimal learning conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStress-Cognition Interaction:\u003c\/strong\u003e Anxiolytic (Selank) + cognitive enhancement (Semax) — how stress reduction influences cognitive performance and vice versa.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune-Neural Integration:\u003c\/strong\u003e Both retain parent molecule immunomodulatory properties — intersection of neuroimmune signaling with cognitive function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSemax \/ Selank Blend\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/semax-selank\"\u003eSemax \/ Selank Blend\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751444810,"sku":"PBL-SEMAXSELANK-10MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-semax-selank-nootropic-blend-20mg-research-grade.webp?v=1773933895"},{"product_id":"vip","title":"VIP","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eVIP — Vasoactive Intestinal Peptide for Neuroimmune and Mucosal Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eVIP\u003c\/strong\u003e is a 28-amino acid neuropeptide (Said \u0026amp; Mutt, 1970). Neurotransmitter and immune modulator acting through VPAC1\/VPAC2 receptors across nervous, immune, endocrine, and GI systems. Over 10,000 published articles.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eVIP activates VPAC1\/2 via Gs-cAMP signaling. In neurons: modulates synaptic transmission and circadian rhythm (key SCN synchronizer). In immune cells: generates tolerogenic DCs, promotes Tregs, shifts Th1→Th2 (\u003cem\u003eNat Rev Immunol\u003c\/em\u003e). In gut: regulates ion transport, blood flow, smooth muscle.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroimmune Modulation:\u003c\/strong\u003e VIPergic nerves innervate lymphoid organs — studies how neuropeptide signaling regulates immune function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCircadian Clock Research:\u003c\/strong\u003e Essential for SCN neuronal synchronization. VPAC2 signaling maintains intercellular clock coupling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegulatory T-Cell Biology:\u003c\/strong\u003e Promotes FoxP3+ Treg differentiation — peripheral tolerance and immune homeostasis mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGut-Brain Axis:\u003c\/strong\u003e Abundant enteric neuropeptide regulating secretion, motility, barrier function, and mucosal immune responses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eVIP\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ara-290\"\u003eARA-290\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752100170,"sku":"PBL-VIP-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-vip-vasoactive-intestinal-peptide-10mg-research-grade.webp?v=1773933905"},{"product_id":"selank","title":"Selank","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSelank — Tuftsin-Derived Heptapeptide for Anxiolytic and Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSelank\u003c\/strong\u003e (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic tuftsin analog with Pro-Gly-Pro extension for stability. Developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Combined anxiolytic and nootropic properties without sedation or dependence.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSelank allosterically enhances GABA-A receptor sensitivity without direct benzodiazepine-site binding. Increases hippocampal BDNF mRNA. Stabilizes enkephalin levels by inhibiting enkephalinase. Modulates 36 genes related to GABAergic, serotonergic, and dopaminergic neurotransmission in the hippocampus.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGABAergic Modulation:\u003c\/strong\u003e Allosteric GABA-A enhancement providing anxiolytic effects without sedation, tolerance, or withdrawal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF and Neuroplasticity:\u003c\/strong\u003e Increased hippocampal BDNF with downstream TrkB-CREB signaling for LTP and memory consolidation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnkephalin Metabolism:\u003c\/strong\u003e Inhibits enkephalin-degrading enzymes for elevated endogenous opioid signaling without mu-agonism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune-Neuro Crosstalk:\u003c\/strong\u003e Retains tuftsin immunomodulatory properties (phagocytosis, IL-6) for studying nervous-immune bidirectional communication.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSelank\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e, and \u003ca href=\"\/products\/dsip\"\u003eDSIP\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753181514,"sku":"PBL-SELANK-6G","price":29.99,"currency_code":"EUR","in_stock":true},{"title":"30","offer_id":60995753214282,"sku":"PBL-SELANK-6G","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-selank-anxiolytic-nootropic-peptide-10mg-research-grade.webp?v=1773935024"},{"product_id":"semax","title":"Semax","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSemax — ACTH(4-10) Analog for Neurotrophic Factor and Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSemax\u003c\/strong\u003e (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic ACTH(4-10) analog developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Pro-Gly-Pro extension confers protease resistance without steroidogenic effects. Over 200 published studies on neurotrophic factor expression and cognitive performance.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSemax upregulates BDNF and TrkB in hippocampus and cortex, increases NGF expression, enhances 5-HT turnover, and activates the MAPK\/ERK cascade for neuronal survival under ischemic conditions.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF \u0026amp; NGF Upregulation:\u003c\/strong\u003e Sustained increases in hippocampal BDNF and cortical NGF — enhanced neurotrophic support documented across independent research groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement Models:\u003c\/strong\u003e Improved Morris water maze, passive avoidance, and novel object recognition correlating with increased LTP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Reduces infarct volume, preserves BBB integrity, maintains neuronal viability in stroke models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Profiling:\u003c\/strong\u003e Transcriptomic analysis reveals modulation of neurotransmitter, immune, vascular, and neuroprotection genes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSemax\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753312586,"sku":"PBL-SEMAX-10MG","price":29.99,"currency_code":"EUR","in_stock":true},{"title":"30","offer_id":60995753345354,"sku":"PBL-SEMAX-10MG","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-semax-nootropic-cognitive-peptide-10mg-research-grade.webp?v=1773935027"},{"product_id":"na-selank-amidate","title":"NA Selank Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Selank Amidate — Stabilized Anxiolytic Neuropeptide for Cognitive and Immunomodulatory Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Selank Amidate\u003c\/strong\u003e is a modified analog of Selank, the synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been extensively studied for its anxiolytic, nootropic, and immunostimulatory properties. The N-acetyl amidate modification confers superior enzymatic stability by protecting both the N-terminal (via acetylation) and C-terminal (via amidation) from exopeptidase degradation, resulting in significantly enhanced bioavailability and prolonged biological activity in research applications.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e modulates the GABAergic system by allosterically influencing GABA-A receptor sensitivity, without directly binding the benzodiazepine site. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2008) demonstrated that Selank analogs increase BDNF (brain-derived neurotrophic factor) mRNA expression in the hippocampus and frontal cortex, promoting neuroplasticity. Additionally, the compound has been shown to modulate the expression of IL-6, IL-10, and TNF-α, suggesting dual neuroimmune regulatory activity. The stabilized form enhances these effects by maintaining effective concentrations over extended experimental timeframes.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnxiolytic Mechanisms:\u003c\/strong\u003e In behavioral models (elevated plus maze, open field test), \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e has demonstrated anxiolytic effects comparable to benzodiazepines without sedation, motor impairment, or dependence potential. Studies in \u003cem\u003eBehavioural Brain Research\u003c\/em\u003e (2009) documented significant reductions in anxiety-like behavior in rodent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Research has shown that Selank analogs enhance memory consolidation and retrieval in passive avoidance and Morris water maze paradigms, mediated through increased BDNF expression and enhanced monoamine neurotransmitter metabolism in hippocampal and prefrontal regions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e As a tuftsin analog, NA Selank Amidate stimulates phagocytic activity and modulates cytokine profiles. Published studies have documented increased natural killer cell activity and balanced Th1\/Th2 immune responses in treated animal models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Investigators have examined the compound's ability to protect neurons from oxidative stress-induced apoptosis, with evidence of enhanced SOD activity and reduced lipid peroxidation markers in cortical neuron cultures following treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-selank-amidate\"\u003eNA Selank Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying anxiolytic neuropeptides and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646629706,"sku":"PBL-NA-SELANK-AMIDATE-30MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-selank-amidate-30mg-research-grade.webp?v=1774393541"},{"product_id":"na-semax-amidate","title":"NA Semax Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Semax Amidate — Enhanced ACTH Analog for Neurotrophic and Cerebrovascular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Semax Amidate\u003c\/strong\u003e is a stabilized derivative of Semax, the synthetic heptapeptide analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied extensively for its pronounced neurotrophic, neuroprotective, and cognitive-enhancing properties. The N-acetyl amidate modification significantly increases the peptide's resistance to aminopeptidase and carboxypeptidase degradation, resulting in an extended half-life and enhanced potency compared to the parent compound in research settings.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e exerts its effects through multiple converging pathways. Research published in \u003cem\u003eNeuroscience Letters\u003c\/em\u003e (2006) demonstrated that Semax analogs rapidly upregulate BDNF and NGF (nerve growth factor) expression in cortical and hippocampal tissues through TrkB receptor-mediated signaling cascades. The compound also modulates dopaminergic and serotoninergic neurotransmission, increasing dopamine and serotonin turnover in the striatum and nucleus accumbens. Additionally, published data in \u003cem\u003eDoklady Biological Sciences\u003c\/em\u003e have shown that Semax analogs influence gene expression patterns related to neurovascular coupling and cerebral blood flow autoregulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotrophic Factor Expression:\u003c\/strong\u003e In-vitro and in-vivo studies have demonstrated that \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e upregulates BDNF, NGF, and NT-3 expression in glial and neuronal cell populations. Research in \u003cem\u003eBrain Research\u003c\/em\u003e (2007) documented a 2-3 fold increase in BDNF mRNA levels in the hippocampus following administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Performance:\u003c\/strong\u003e Behavioral studies using novel object recognition, radial arm maze, and contextual fear conditioning paradigms have shown significant enhancements in learning acquisition and memory retention in rodent models treated with Semax analogs, with the stabilized form demonstrating prolonged effect duration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCerebrovascular Research:\u003c\/strong\u003e Investigators have studied the compound's effects on cerebral hemodynamics, documenting improved cerebral blood flow autoregulation and reduced infarct volume in models of focal cerebral ischemia, mediated through NO-dependent vasodilation and neurovascular unit protection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroinflammation:\u003c\/strong\u003e Research has demonstrated that NA Semax Amidate modulates microglial activation states, promoting the M2 anti-inflammatory phenotype while attenuating pro-inflammatory cytokine release (IL-1β, TNF-α) in lipopolysaccharide-challenged neuronal co-cultures.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-semax-amidate\"\u003eNA Semax Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying neurotrophic signaling and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646793546,"sku":"PBL-NA-SEMAX-AMIDATE-30MG","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-semax-amidate-30mg-research-grade.webp?v=1774393542"},{"product_id":"p21","title":"P21","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eP21 (P021) — CNTF-Derived Neurotrophic Peptide for Neurogenesis Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eP21\u003c\/strong\u003e, also known as P021, is an 11-mer synthetic peptide derived from the ciliary neurotrophic factor (CNTF) active region, developed by Dr. Khalid Iqbal's group at the New York State Institute for Basic Research in Developmental Disabilities. Published in \u003cem\u003eNeurobiology of Aging\u003c\/em\u003e (2013) and \u003cem\u003eJournal of Alzheimer's Disease\u003c\/em\u003e, P21 was designed to mimic CNTF's neurotrophic properties while possessing enhanced blood-brain barrier permeability and oral bioavailability. This compound has emerged as a key research tool for studying adult hippocampal neurogenesis and synaptic plasticity.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eP21\u003c\/strong\u003e enhances the expression of brain-derived neurotrophic factor (BDNF) through inhibition of leukemia inhibitory factor (LIF) signaling. By competitively binding the LIF receptor without activating downstream JAK\/STAT signaling, P21 releases tonic inhibition on BDNF transcription. Elevated BDNF subsequently activates TrkB receptor cascades, promoting neuronal survival, dendritic arborization, and synaptic strengthening. Additionally, P21 has been shown to decrease glycogen synthase kinase 3β (GSK-3β) activity, reducing tau hyperphosphorylation in neuronal culture models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdult Neurogenesis:\u003c\/strong\u003e Studies using BrdU-labeled neuronal progenitors in aged mouse hippocampus have demonstrated that \u003cstrong\u003eP21\u003c\/strong\u003e significantly increases neurogenesis in the subgranular zone of the dentate gyrus, with newly generated neurons exhibiting mature electrophysiological properties.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Morris water maze and novel object recognition studies in 3xTg-AD mouse models have shown significant improvements in spatial and recognition memory following chronic P21 administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTau Pathology:\u003c\/strong\u003e Research has demonstrated that P21 reduces phosphorylated tau levels at multiple epitopes (AT8, PHF-1, AT180) in transgenic Alzheimer's disease models, correlating with improved synaptic density markers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynaptic Plasticity:\u003c\/strong\u003e Electrophysiological studies have shown enhanced long-term potentiation (LTP) in hippocampal slices from P21-treated animals, with increased expression of synaptic scaffold proteins PSD-95 and synaptophysin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 50mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eP21\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying neurogenesis and cognitive function may also find these compounds relevant: \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Function Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737954122,"sku":"PBL-P21-50MG","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-p21-nootropic-peptide-50mg-research-grade.webp?v=1774393569"},{"product_id":"adamax","title":"Adamax","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAdamax (Adamantyl-Semax) — Enhanced Nootropic Peptide for Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdamax\u003c\/strong\u003e, also known as Adamantyl-Semax, is a structurally modified derivative of Semax (MEHFPGP) featuring an adamantane group conjugation that enhances blood-brain barrier penetration and receptor binding affinity. Building upon the extensive research foundation of Semax, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, \u003cstrong\u003eAdamax\u003c\/strong\u003e represents a next-generation nootropic research tool. The adamantane modification—a strategy also employed in pharmaceutical compounds like amantadine and memantine—confers increased lipophilicity and metabolic stability compared to the parent peptide.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAdamax\u003c\/strong\u003e retains and enhances Semax's primary mechanisms while exhibiting improved pharmacokinetic properties. The compound activates melanocortin MC3 and MC4 receptor subtypes in the central nervous system, stimulating BDNF and NGF expression through CREB-dependent transcriptional activation. The adamantane moiety increases membrane permeability and provides steric protection against enzymatic degradation, resulting in prolonged receptor engagement. Additional research suggests NMDA receptor modulation and enhanced cholinergic transmission in hippocampal circuits.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotrophic Factor Expression:\u003c\/strong\u003e Comparative studies have demonstrated that \u003cstrong\u003eAdamax\u003c\/strong\u003e produces significantly greater BDNF mRNA upregulation in hippocampal neuronal cultures compared to equimolar concentrations of native Semax, suggesting enhanced potency from the adamantane modification.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Behavioral studies in rodent models have shown improvements in spatial learning (radial arm maze), working memory (delayed match-to-sample), and attention (5-choice serial reaction time task) following Adamax administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e In ischemia-reperfusion models, Adamax has demonstrated reduced infarct volume and preserved neuronal density in the CA1 hippocampal region, with effects superior to those observed with native Semax at equivalent doses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic Enhancement:\u003c\/strong\u003e In-vivo distribution studies have confirmed increased CNS bioavailability of the adamantyl conjugate compared to unmodified Semax, with detectable peptide levels in cerebrospinal fluid at lower peripheral doses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAdamax\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying nootropic peptides and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/na-semax-amidate\"\u003eNA Semax Amidate\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Function Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420738249034,"sku":"PBL-ADAMAX-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-adamax-nootropic-peptide-10mg-research-grade.webp?v=1774393573"},{"product_id":"cortagen","title":"Cortagen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCortagen (Ala-Glu-Asp-Pro) — Cerebral Cortex Bioregulator for Neurological Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCortagen\u003c\/strong\u003e is a synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Pro) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. Designed as a cortex-specific bioregulator, Cortagen has been characterized for its selective modulatory effects on cerebral cortical neuron gene expression and neurotransmitter balance. Research published in \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e and \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its capacity to normalize age-related neurodegenerative changes and restore cognitive parameters in aged experimental models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCortagen\u003c\/strong\u003e penetrates the blood-brain barrier and interacts with DNA sequences in promoter regions of genes critical for neuronal function in the cerebral cortex. The AEDP tetrapeptide modulates chromatin accessibility at loci encoding neurotrophic factors (BDNF, NGF), synaptic plasticity proteins (PSD-95, CaMKII), and neurotransmitter synthesis enzymes. Research has demonstrated that Cortagen normalizes the balance between excitatory and inhibitory neurotransmission by modulating glutamic acid decarboxylase (GAD) expression and GABA receptor subunit composition in cortical tissue.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCortical Neuron Function:\u003c\/strong\u003e In-vitro studies on primary cortical neuron cultures have demonstrated that \u003cstrong\u003eCortagen\u003c\/strong\u003e preserves dendritic spine density and synaptic marker expression under oxidative stress conditions, with significant upregulation of synaptophysin and PSD-95.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Aging:\u003c\/strong\u003e Behavioral studies in aged rodent models have shown improved performance in spatial navigation (Morris water maze), attentional processing (5-CSRTT), and working memory tasks following chronic Cortagen administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotransmitter Homeostasis:\u003c\/strong\u003e Microdialysis studies have demonstrated normalized dopamine and serotonin turnover ratios in the prefrontal cortex of aged animals treated with Cortagen, correlating with restored executive function measures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Research has observed reduced neuronal apoptosis markers (cleaved caspase-3, TUNEL positivity) and preserved cortical thickness in aged brain tissue following long-term Cortagen treatment protocols.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Ala-Glu-Asp-Pro (AEDP tetrapeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 430.41 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCortagen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying cerebral bioregulation and neuroprotection may also find these compounds relevant: \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Function Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420760990026,"sku":"PBL-CORTAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cortagen-bioregulator-peptide-10mg-research-grade.webp?v=1774393579"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/collections\/peptides-biolab-semax-nootropic-cognitive-peptide-10mg-research-grade.webp?v=1774382730","url":"https:\/\/peptides-biolab.com\/collections\/cognitive-function.oembed","provider":"Peptides BioLab","version":"1.0","type":"link"}