{"title":"Muscle Building","description":"\u003cp\u003eOur muscle building collection features peptides studied for muscle protein synthesis, recovery, and anabolic signaling pathways. All compounds are research-grade with verified ≥98% purity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Anabolic Peptides\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBPC-157\u003c\/strong\u003e - Gastric pentadecapeptide researched for tissue repair, angiogenesis, and recovery\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTB-500 (Thymosin Beta-4)\u003c\/strong\u003e - Actin-regulating peptide studied for muscle regeneration and inflammation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFollistatin-344\u003c\/strong\u003e - Myostatin inhibitor investigated for muscle growth and satellite cell activation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e - Growth factor studied for muscle hypertrophy and protein synthesis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePEG-MGF\u003c\/strong\u003e - Mechano growth factor researched for muscle repair and growth\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMuscle protein synthesis and mTOR activation\u003c\/li\u003e\n\u003cli\u003eSatellite cell proliferation and differentiation\u003c\/li\u003e\n\u003cli\u003eMyostatin inhibition and muscle hyperplasia\u003c\/li\u003e\n\u003cli\u003eRecovery from muscle damage and inflammation\u003c\/li\u003e\n\u003cli\u003eConnective tissue repair and collagen synthesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cstrong\u003eQuality Standards:\u003c\/strong\u003e All Peptides BioLab anabolic peptides are for research use only, synthesized to ≥98% purity (HPLC), and supplied with Certificate of Analysis. Not for human consumption.\u003c\/p\u003e","products":[{"product_id":"ghrp-6","title":"GHRP-6","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHRP-6 — Hexapeptide Ghrelin Receptor Agonist for GH Secretion Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHRP-6\u003c\/strong\u003e is a synthetic hexapeptide GHS-R1a agonist developed by Bowers et al. (\u003cem\u003eEndocrinology\u003c\/em\u003e, 1984). Among the earliest synthetic GH secretagogues, it stimulates pituitary GH release through a mechanism distinct from GHRH.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eGHRP-6 binds GHS-R1a, activating PLC and IP3\/DAG signaling for calcium release and GH exocytosis. Complementary to GHRH (cAMP-PKA), explaining synergistic GH release when combined. Also suppresses somatostatin and stimulates appetite via NPY\/AgRP neurons.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Secretagogue Research:\u003c\/strong\u003e Robust dose-dependent GH release through ghrelin receptor pathway, studying GHRH-GHS interplay.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin Receptor Biology:\u003c\/strong\u003e Reference compound for GHS-R1a pharmacology, constitutive activity, and desensitization kinetics.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppetite and Energy Balance:\u003c\/strong\u003e Stimulates food intake via central NPY\/AgRP mechanisms for orexigenic signaling research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCytoprotective Effects:\u003c\/strong\u003e Protective effects in cardiac and hepatic ischemia-reperfusion, independent of GH release.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHRP-6\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e, and \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751903562,"sku":"PBL-GHRP-6-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghrp-6-acetate-peptide-10mg-research-grade.webp?v=1773933880"},{"product_id":"ace-031","title":"ACE-031","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eACE-031 — Soluble ActRIIB Decoy Receptor for Myostatin Pathway Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1. This soluble decoy receptor binds and neutralizes members of the TGF-β superfamily, including myostatin and activins, which are negative regulators of skeletal muscle mass. Originally developed by Acceleron Pharma and studied in clinical trials for neuromuscular conditions, \u003cstrong\u003eACE-031\u003c\/strong\u003e remains a critical research tool for investigating muscle growth regulation pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e functions as a ligand trap, sequestering myostatin (GDF-8) and related TGF-β family ligands before they can bind to endogenous ActRIIB receptors on cell surfaces. By intercepting these signaling molecules, the compound effectively blocks the SMAD2\/3 phosphorylation cascade that normally suppresses muscle protein synthesis. Studies published in \u003cem\u003eMolecular and Cellular Endocrinology\u003c\/em\u003e (2010) demonstrated that ActRIIB-Fc administration in murine models resulted in significant increases in lean muscle mass, independent of physical activity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Inhibition:\u003c\/strong\u003e \u003cstrong\u003eACE-031\u003c\/strong\u003e has been extensively studied as a myostatin antagonist. In preclinical models, treatment resulted in dose-dependent increases in skeletal muscle mass, with research in \u003cem\u003eMuscle \u0026amp; Nerve\u003c\/em\u003e (2013) documenting significant effects on both fast-twitch and slow-twitch fiber types.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromuscular Disease Models:\u003c\/strong\u003e Researchers have investigated ACE-031 in the mdx mouse model of Duchenne muscular dystrophy, where it demonstrated preservation of muscle function and reduced fibrosis without directly targeting the underlying genetic defect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone Mineral Density:\u003c\/strong\u003e Published research has observed concurrent increases in bone mineral density alongside muscle mass gains, suggesting dual anabolic effects mediated through TGF-β pathway modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Regulation:\u003c\/strong\u003e ActRIIB pathway blockade has been associated with reduced adiposity in animal models, with researchers observing improved glucose tolerance and insulin sensitivity alongside muscle hypertrophy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eACE-031\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying muscle growth regulation and TGF-β signaling may also find these compounds relevant: \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751936330,"sku":"PBL-ACE-031-6G","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ace-031-peptide-1mg-research-grade.webp?v=1773933871"},{"product_id":"peg-mgf","title":"PEG MGF","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePEG-MGF — Pegylated Mechano Growth Factor for Skeletal Muscle Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePEG-MGF\u003c\/strong\u003e is a PEGylated form of the IGF-1Ec splice variant, a mechanically sensitive growth factor produced after exercise or tissue damage. PEGylation extends half-life from minutes to hours. Used in satellite cell activation and muscle hypertrophy research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePEG-MGF activates satellite cells — resident muscle stem cells — promoting proliferation and migration to damage sites. MGF exerts autocrine\/paracrine effects within muscle microenvironment. Goldspink (\u003cem\u003eJ Physiology\u003c\/em\u003e, 2003) showed MGF is an immediate early gene response to mechanical overload, preceding liver-type IGF-1Ea expression.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSatellite Cell Activation:\u003c\/strong\u003e Activates quiescent satellite cells, promoting cell cycle entry — critical first step in muscle repair and adaptive hypertrophy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechano-Transduction:\u003c\/strong\u003e MGF expression is a direct readout of mechanical loading, separating growth factor signal from mechanical stimulus.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Regeneration:\u003c\/strong\u003e Enhanced myoblast proliferation, migration, and fusion in injury models with accelerated contractile function restoration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 Splice Variant Biology:\u003c\/strong\u003e Study distinct biological roles of mechano-sensitive vs. liver-derived IGF-1 isoforms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePEG-MGF\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, and \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752165706,"sku":"PBL-PEGMGF-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-peg-mgf-peptide-2mg-research-grade.webp?v=1773933890"},{"product_id":"follistatin-344","title":"Follistatin 344","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eFollistatin 344 — Activin-Binding Glycoprotein for Myostatin Antagonism Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFollistatin 344\u003c\/strong\u003e (FST344) is a 344-amino acid glycoprotein that antagonizes activin, myostatin (GDF-8), and other TGF-β superfamily ligands. Research in \u003cem\u003eFASEB Journal\u003c\/em\u003e (2005) showed dramatic skeletal muscle mass increases in multiple animal models.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eFollistatin neutralizes TGF-β members through direct protein-protein interactions. Its three FS domains create a binding surface complementary to activin and myostatin receptor-binding epitopes, preventing ActRII\/ALK4 activation and SMAD2\/3 signaling. PNAS research showed sustained muscle mass increases in non-human primate gene delivery models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Antagonism:\u003c\/strong\u003e Binds myostatin with nanomolar affinity, preventing ActRIIB signaling. Studied for effects on muscle fiber hypertrophy and satellite cell proliferation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivin Signaling:\u003c\/strong\u003e Regulates activin A\/B signaling influencing reproductive biology, inflammatory responses, and hepatic glucose metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Therapy Models:\u003c\/strong\u003e Used in AAV-mediated gene delivery for sustained muscle mass — proof-of-concept for neuromuscular gene therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Regeneration:\u003c\/strong\u003e Enhances satellite cell activation and myoblast fusion in damaged muscle tissue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eFollistatin 344\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752198474,"sku":"PBL-FOLLISTATIN344-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-follistatin-344-myostatin-inhibitor-1mg-research-grade.webp?v=1773935005"},{"product_id":"5-amino1-mq","title":"5-Amino1-mq","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003e5-Amino-1MQ — A Selective NNMT Inhibitor for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e (5-Amino-1-methylquinolinium) is a small molecule compound that has gained significant attention in metabolic research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). First characterized in studies published by Neelakantan et al. (2017) in \u003cem\u003eBiochemical Pharmacology\u003c\/em\u003e, this compound has demonstrated notable effects on adipocyte metabolism and energy expenditure pathways in preclinical models, making it a valuable tool for researchers investigating obesity-related metabolic dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e functions by selectively inhibiting NNMT, an enzyme that regulates cellular energy metabolism through the methylation of nicotinamide. By blocking NNMT activity, this compound increases intracellular NAD+ concentrations and activates the SAM-dependent methylation cycle. In adipocyte models, NNMT inhibition has been associated with increased expression of energy expenditure genes and reduced lipogenesis. Research published in \u003cem\u003eObesity\u003c\/em\u003e (2018) demonstrated that NNMT inhibition led to significant reductions in fat mass without affecting lean tissue in murine models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdipocyte Metabolism:\u003c\/strong\u003e In-vitro studies have shown that \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e reduces lipid accumulation in 3T3-L1 adipocytes by increasing NAD+ availability and stimulating sirtuin-dependent metabolic pathways. These findings suggest potential applications in obesity-related metabolic research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNAD+ Biosynthesis:\u003c\/strong\u003e By inhibiting NNMT, this compound redirects nicotinamide toward the NAD+ salvage pathway, effectively increasing cellular NAD+ pools. This mechanism is of particular interest to researchers studying age-related NAD+ decline and mitochondrial function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy Expenditure:\u003c\/strong\u003e Preclinical studies have observed increased oxygen consumption rates and thermogenic gene expression in white adipose tissue following NNMT inhibition, indicating enhanced cellular energy expenditure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Syndrome Pathways:\u003c\/strong\u003e Researchers have investigated the compound's effects on insulin signaling and glucose homeostasis in diet-induced obesity models, with published data suggesting improvements in metabolic biomarkers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying metabolic pathways and energy expenditure may also find these compounds relevant to their work: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752296778,"sku":"PBL-5-AMINO1-MQ-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-5-amino-1mq-fat-metabolism-peptide-50mg-research-grade.webp?v=1773935006"},{"product_id":"igf1-lr3","title":"IGF1-LR3","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eIGF-1 LR3 — Long-Acting Growth Factor Analog for Proliferation Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e is an 83-amino acid analog of human IGF-1 with reduced IGFBP binding (Arg3→Glu + 13-AA N-terminal extension), resulting in extended half-life and ~3× greater potency than native IGF-1 in cell proliferation assays.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIGF-1 LR3 activates IGF-1R, triggering PI3K\/Akt\/mTOR and Ras\/Raf\/MAPK cascades. Less than 1% affinity for IGFBP-3 keeps more peptide in active form. Standard component of serum-free culture media for myoblasts, fibroblasts, and stem cells.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Culture Applications:\u003c\/strong\u003e Standard growth supplement in serum-free media for myoblasts, fibroblasts, epithelial cells, and stem cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1R Signaling:\u003c\/strong\u003e Study receptor activation kinetics, PI3K\/Akt signaling, and sustained IGF-1R stimulation effects on cell cycle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Cell Biology:\u003c\/strong\u003e Promotes myoblast proliferation, MyoD expression, and myotube formation in muscle cell cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGFBP-Independent Signaling:\u003c\/strong\u003e Reduced IGFBP binding enables clean analysis of receptor-level events without sequestration confounds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e, \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, and \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752362314,"sku":"PBL-IGF1-LR3-6G","price":89.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-igf1-lr3-insulin-growth-factor-1mg-research-grade.webp?v=1773935008"},{"product_id":"mgf-mechano-growth-factor","title":"MGF (Mechano Growth Factor)","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMGF (Mechano Growth Factor) — Splice Variant of IGF-1 for Muscle Biology and Regeneration Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMGF (Mechano Growth Factor)\u003c\/strong\u003e is a splice variant of the Insulin-like Growth Factor 1 (IGF-1) gene, specifically the IGF-1Ec isoform in humans (IGF-1Eb in rodents). Unlike the systemic IGF-1Ea isoform that is primarily hepatic in origin, MGF is produced locally within mechanically stressed skeletal muscle tissue and is characterized by a unique 24-amino acid C-terminal E-domain extension. First described by Goldspink et al. at University College London, \u003cstrong\u003eMGF\u003c\/strong\u003e has been shown to activate satellite cells (muscle stem cells) and initiate muscle repair cascades, making it an indispensable tool for researchers studying exercise physiology, muscle regeneration, and mechano-transduction pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMGF\u003c\/strong\u003e exerts its biological effects primarily through its unique E-domain peptide, which is distinct from the mature IGF-1 receptor-binding domain. Research published in \u003cem\u003eJournal of Physiology\u003c\/em\u003e (2003) demonstrated that the MGF E-domain activates satellite cells by stimulating their proliferation without promoting differentiation — a critical distinction from mature IGF-1, which drives terminal differentiation. This activation involves upregulation of MyoD and Myf5 transcription factors while suppressing myogenin expression. Additionally, MGF has been shown to activate the Akt\/mTOR pathway in an IGF-1R-independent manner, suggesting a distinct signaling mechanism through a putative E-domain receptor.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSatellite Cell Activation:\u003c\/strong\u003e In-vitro studies using primary myoblast cultures have demonstrated that \u003cstrong\u003eMGF\u003c\/strong\u003e promotes satellite cell proliferation at significantly lower concentrations than mature IGF-1, with the E-domain peptide alone sufficient to drive this mitogenic effect, enabling researchers to dissect the specific contribution of mechano-sensitive IGF-1 splicing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Damage and Repair:\u003c\/strong\u003e Preclinical models of exercise-induced and toxin-induced muscle damage have shown that MGF expression peaks within 24 hours of injury, preceding IGF-1Ea upregulation. Exogenous MGF administration has been observed to accelerate the regenerative timeline in cardiotoxin-injured murine muscle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechano-Transduction:\u003c\/strong\u003e Researchers have used MGF as a marker and effector to study how mechanical loading signals are transduced into molecular repair responses, with evidence that MGF expression is regulated by the calcineurin\/NFAT and p38 MAPK signaling cascades.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Muscle Decline:\u003c\/strong\u003e Studies have documented diminished MGF splicing efficiency in aged muscle tissue, suggesting impaired mechano-sensitive IGF-1 processing may contribute to sarcopenia, providing a model system for studying age-related muscle wasting.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMGF\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mgf-mechano-growth-factor\"\u003eMGF\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying IGF-1 signaling and muscle biology may also find these compounds relevant: \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/muscle-building\"\u003eMuscle Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647252298,"sku":"PBL-MGF-2MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mgf-mechano-growth-factor-2mg-research-grade.webp?v=1774393550"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/collections\/peptides-biolab-follistatin-344-myostatin-inhibitor-1mg-research-grade.webp?v=1774382736","url":"https:\/\/peptides-biolab.com\/collections\/muscle-building.oembed","provider":"Peptides BioLab","version":"1.0","type":"link"}