{"title":"Weight Loss","description":"\u003cp\u003eResearch-grade peptides for metabolic studies and weight loss research. All products tested to ≥98% purity (HPLC) with Certificate of Analysis. For research applications only, not for human consumption.\u003c\/p\u003e","products":[{"product_id":"hgh-fragment-176-191","title":"HGH Fragment 176-191","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eHGH Fragment 176-191 — Growth Hormone Lipolytic Domain for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e is a modified segment of the human growth hormone (hGH) molecule, corresponding to amino acids 176 through 191 of the C-terminal region. This peptide fragment retains the lipolytic activity of full-length hGH without its growth-promoting or diabetogenic properties. Research published by Ng et al. (2000) in \u003cem\u003eEndocrinology\u003c\/em\u003e first characterized this fragment's ability to stimulate lipolysis and inhibit lipogenesis in adipose tissue models, establishing it as a valuable research tool for studying fat metabolism independent of IGF-1 axis activation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e acts on adipocytes through a mechanism distinct from full-length growth hormone. While hGH stimulates lipolysis via JAK2\/STAT5 signaling, the 176-191 fragment appears to engage a beta-3 adrenergic receptor-mediated pathway, enhancing cyclic AMP production and activating hormone-sensitive lipase (HSL). Importantly, this fragment does not compete for GH receptor binding and does not stimulate IGF-1 secretion, providing researchers with a tool to study fat-specific metabolic effects in isolation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipolysis and Fat Metabolism:\u003c\/strong\u003e In-vitro studies on human and murine adipocytes have demonstrated that \u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e stimulates lipolysis at rates comparable to full-length hGH, while exhibiting no effect on longitudinal bone growth or glucose homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Lipogenic Activity:\u003c\/strong\u003e Research has shown this fragment inhibits de novo lipogenesis in adipocyte cultures, reducing fatty acid synthase (FAS) expression and decreasing triglyceride accumulation in dose-dependent fashion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Selectivity:\u003c\/strong\u003e Unlike full-length hGH, the 176-191 fragment does not impair insulin sensitivity in preclinical models, making it a tool for studying lipolytic pathways without confounding hyperglycemic effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity Research Models:\u003c\/strong\u003e Chronic administration studies in ob\/ob mouse models have demonstrated reductions in body fat percentage without changes in food intake or lean body mass.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying fat metabolism and growth hormone pathways may also find these compounds relevant: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/weight-loss\"\u003eWeight Loss Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737397066,"sku":"PBL-HGHFRAG176-5MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-hgh-fragment-176-191-5mg-research-grade.webp?v=1774393558"},{"product_id":"adipotide","title":"Adipotide","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAdipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) — Proapoptotic Vascular-Targeting Peptide for Obesity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdipotide\u003c\/strong\u003e, also designated as Prohibitin-TP01, is a chimeric peptidomimetic composed of a vascular homing domain (CKGGRAKDC) linked to a proapoptotic sequence D(KLAKLAK)₂. Originally developed at the University of Texas MD Anderson Cancer Center and published by Kolonin et al. (2004) in \u003cem\u003eNature Medicine\u003c\/em\u003e, \u003cstrong\u003eAdipotide\u003c\/strong\u003e selectively targets prohibitin on the surface of blood vessels supplying white adipose tissue, inducing targeted apoptosis in adipose vasculature. This unique mechanism provides researchers with a tool for studying vascular-targeted approaches to adipose tissue remodeling.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eThe CKGGRAKDC motif of \u003cstrong\u003eAdipotide\u003c\/strong\u003e binds with high affinity to prohibitin, a receptor specifically expressed on the endothelial surface of white adipose tissue vasculature. Upon receptor binding, the conjugated D(KLAKLAK)₂ domain—a synthetic peptide engineered to disrupt mitochondrial membranes—is internalized into endothelial cells via receptor-mediated endocytosis. Once intracellular, the proapoptotic domain permeabilizes mitochondrial membranes, triggering cytochrome c release and caspase-mediated apoptosis selectively in adipose vascular endothelium.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargeted Adipose Ablation:\u003c\/strong\u003e In non-human primate studies published in \u003cem\u003eScience Translational Medicine\u003c\/em\u003e (2012), \u003cstrong\u003eAdipotide\u003c\/strong\u003e treatment resulted in significant dose-dependent reductions in body mass index, abdominal circumference, and total body fat measured by DEXA scanning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVascular Biology of Adipose Tissue:\u003c\/strong\u003e The compound has enabled researchers to map prohibitin expression patterns across different adipose depots, revealing heterogeneity in vascular surface receptor profiles between visceral and subcutaneous fat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Parameter Modulation:\u003c\/strong\u003e Preclinical studies observed improvements in insulin sensitivity and lipid profiles concurrent with adipose mass reduction, providing insights into the relationship between adipose vascularization and metabolic health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide-Drug Conjugate Design:\u003c\/strong\u003e Adipotide serves as a prototype for vascular-targeted peptide therapeutics, informing researchers designing next-generation tissue-selective delivery systems.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAdipotide\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying adipose biology and metabolic regulation may also find these compounds relevant: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/weight-loss\"\u003eWeight Loss Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737495370,"sku":"PBL-ADIPOTIDE-5MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-adipotide-peptide-5mg-research-grade.webp?v=1774393560"},{"product_id":"mazdutide","title":"Mazdutide","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMazdutide (LY3305677) — Dual GLP-1\/Glucagon Receptor Agonist for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMazdutide\u003c\/strong\u003e (INN; also known as LY3305677) is a novel long-acting dual agonist peptide targeting both glucagon-like peptide-1 (GLP-1) and glucagon receptors. Developed by Innovent Biologics in collaboration with Eli Lilly, mazdutide has been the subject of multiple clinical trials published in \u003cem\u003eThe Lancet Diabetes \u0026amp; Endocrinology\u003c\/em\u003e and \u003cem\u003eNature Medicine\u003c\/em\u003e (2023-2024), demonstrating significant effects on body weight reduction and glycemic control. As a dual-action incretin analog, mazdutide provides researchers with a unique pharmacological tool for studying the synergistic metabolic effects of simultaneous GLP-1 and glucagon receptor engagement.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMazdutide\u003c\/strong\u003e is engineered as a peptide-Fc fusion construct with balanced agonist activity at both GLP-1R and GCGR. The GLP-1 receptor component activates Gs-coupled cAMP signaling in pancreatic beta cells, enhancing glucose-dependent insulin secretion, slowing gastric emptying, and activating hypothalamic satiety centers. Simultaneously, the glucagon receptor agonist component stimulates hepatic glycogenolysis, increases energy expenditure through thermogenesis in brown adipose tissue, and promotes hepatic lipid oxidation. The dual mechanism produces complementary metabolic effects—GLP-1R mediating appetite suppression and insulin secretion, while GCGR drives energy expenditure and fat oxidation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWeight Management:\u003c\/strong\u003e Phase II\/III clinical trials have demonstrated that \u003cstrong\u003eMazdutide\u003c\/strong\u003e produces dose-dependent body weight reductions of 10-15% over 24-48 week treatment periods in obese subjects, with superior weight loss kinetics compared to GLP-1-only receptor agonists in head-to-head preclinical comparisons.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlycemic Control:\u003c\/strong\u003e Research has documented significant HbA1c reductions (1.5-2.0 percentage points) in type 2 diabetes models, with the dual agonism providing both insulin-dependent (GLP-1R) and insulin-independent (GCGR-mediated hepatic glucose output suppression) glycemic control mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy Expenditure:\u003c\/strong\u003e Indirect calorimetry studies have demonstrated increased resting metabolic rate and enhanced diet-induced thermogenesis following mazdutide administration, attributed to GCGR-mediated activation of brown adipose tissue UCP1 expression and hepatic FGF21 secretion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic Lipid Metabolism:\u003c\/strong\u003e Research has observed significant reductions in intrahepatic triglyceride content (measured by MRI-PDFF), decreased serum ALT levels, and improved NAFLD activity scores in preclinical NASH models treated with dual GLP-1\/glucagon agonists.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMazdutide\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying incretin biology and metabolic regulation may also find these compounds relevant: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/weight-loss\"\u003eWeight Loss Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420787532106,"sku":"PBL-MAZDUTIDE-5MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mazdutide-peptide-5mg-research-grade.webp?v=1774393604"}],"url":"https:\/\/peptides-biolab.com\/collections\/weight-loss.oembed","provider":"Peptides BioLab","version":"1.0","type":"link"}