{"product_id":"5-amino1-mq","title":"5-Amino1-mq","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003e5-Amino-1MQ — A Selective NNMT Inhibitor for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e (5-Amino-1-methylquinolinium) is a small molecule compound that has gained significant attention in metabolic research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). First characterized in studies published by Neelakantan et al. (2017) in \u003cem\u003eBiochemical Pharmacology\u003c\/em\u003e, this compound has demonstrated notable effects on adipocyte metabolism and energy expenditure pathways in preclinical models, making it a valuable tool for researchers investigating obesity-related metabolic dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e functions by selectively inhibiting NNMT, an enzyme that regulates cellular energy metabolism through the methylation of nicotinamide. By blocking NNMT activity, this compound increases intracellular NAD+ concentrations and activates the SAM-dependent methylation cycle. In adipocyte models, NNMT inhibition has been associated with increased expression of energy expenditure genes and reduced lipogenesis. Research published in \u003cem\u003eObesity\u003c\/em\u003e (2018) demonstrated that NNMT inhibition led to significant reductions in fat mass without affecting lean tissue in murine models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdipocyte Metabolism:\u003c\/strong\u003e In-vitro studies have shown that \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e reduces lipid accumulation in 3T3-L1 adipocytes by increasing NAD+ availability and stimulating sirtuin-dependent metabolic pathways. These findings suggest potential applications in obesity-related metabolic research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNAD+ Biosynthesis:\u003c\/strong\u003e By inhibiting NNMT, this compound redirects nicotinamide toward the NAD+ salvage pathway, effectively increasing cellular NAD+ pools. This mechanism is of particular interest to researchers studying age-related NAD+ decline and mitochondrial function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy Expenditure:\u003c\/strong\u003e Preclinical studies have observed increased oxygen consumption rates and thermogenic gene expression in white adipose tissue following NNMT inhibition, indicating enhanced cellular energy expenditure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Syndrome Pathways:\u003c\/strong\u003e Researchers have investigated the compound's effects on insulin signaling and glucose homeostasis in diet-induced obesity models, with published data suggesting improvements in metabolic biomarkers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying metabolic pathways and energy expenditure may also find these compounds relevant to their work: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752296778,"sku":"PBL-5-AMINO1-MQ-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-5-amino-1mq-fat-metabolism-peptide-50mg-research-grade.webp?v=1773935006","url":"https:\/\/peptides-biolab.com\/products\/5-amino1-mq","provider":"Peptides BioLab","version":"1.0","type":"link"}