{"product_id":"ace-031","title":"ACE-031","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eACE-031 — Soluble ActRIIB Decoy Receptor for Myostatin Pathway Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1. This soluble decoy receptor binds and neutralizes members of the TGF-β superfamily, including myostatin and activins, which are negative regulators of skeletal muscle mass. Originally developed by Acceleron Pharma and studied in clinical trials for neuromuscular conditions, \u003cstrong\u003eACE-031\u003c\/strong\u003e remains a critical research tool for investigating muscle growth regulation pathways.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eACE-031\u003c\/strong\u003e functions as a ligand trap, sequestering myostatin (GDF-8) and related TGF-β family ligands before they can bind to endogenous ActRIIB receptors on cell surfaces. By intercepting these signaling molecules, the compound effectively blocks the SMAD2\/3 phosphorylation cascade that normally suppresses muscle protein synthesis. Studies published in \u003cem\u003eMolecular and Cellular Endocrinology\u003c\/em\u003e (2010) demonstrated that ActRIIB-Fc administration in murine models resulted in significant increases in lean muscle mass, independent of physical activity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Inhibition:\u003c\/strong\u003e \u003cstrong\u003eACE-031\u003c\/strong\u003e has been extensively studied as a myostatin antagonist. In preclinical models, treatment resulted in dose-dependent increases in skeletal muscle mass, with research in \u003cem\u003eMuscle \u0026amp; Nerve\u003c\/em\u003e (2013) documenting significant effects on both fast-twitch and slow-twitch fiber types.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromuscular Disease Models:\u003c\/strong\u003e Researchers have investigated ACE-031 in the mdx mouse model of Duchenne muscular dystrophy, where it demonstrated preservation of muscle function and reduced fibrosis without directly targeting the underlying genetic defect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone Mineral Density:\u003c\/strong\u003e Published research has observed concurrent increases in bone mineral density alongside muscle mass gains, suggesting dual anabolic effects mediated through TGF-β pathway modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Regulation:\u003c\/strong\u003e ActRIIB pathway blockade has been associated with reduced adiposity in animal models, with researchers observing improved glucose tolerance and insulin sensitivity alongside muscle hypertrophy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eACE-031\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying muscle growth regulation and TGF-β signaling may also find these compounds relevant: \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751936330,"sku":"PBL-ACE-031-6G","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ace-031-peptide-1mg-research-grade.webp?v=1773933871","url":"https:\/\/peptides-biolab.com\/products\/ace-031","provider":"Peptides BioLab","version":"1.0","type":"link"}