{"product_id":"adamax","title":"Adamax","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAdamax (Adamantyl-Semax) — Enhanced Nootropic Peptide for Cognitive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdamax\u003c\/strong\u003e, also known as Adamantyl-Semax, is a structurally modified derivative of Semax (MEHFPGP) featuring an adamantane group conjugation that enhances blood-brain barrier penetration and receptor binding affinity. Building upon the extensive research foundation of Semax, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, \u003cstrong\u003eAdamax\u003c\/strong\u003e represents a next-generation nootropic research tool. The adamantane modification—a strategy also employed in pharmaceutical compounds like amantadine and memantine—confers increased lipophilicity and metabolic stability compared to the parent peptide.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAdamax\u003c\/strong\u003e retains and enhances Semax's primary mechanisms while exhibiting improved pharmacokinetic properties. The compound activates melanocortin MC3 and MC4 receptor subtypes in the central nervous system, stimulating BDNF and NGF expression through CREB-dependent transcriptional activation. The adamantane moiety increases membrane permeability and provides steric protection against enzymatic degradation, resulting in prolonged receptor engagement. Additional research suggests NMDA receptor modulation and enhanced cholinergic transmission in hippocampal circuits.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotrophic Factor Expression:\u003c\/strong\u003e Comparative studies have demonstrated that \u003cstrong\u003eAdamax\u003c\/strong\u003e produces significantly greater BDNF mRNA upregulation in hippocampal neuronal cultures compared to equimolar concentrations of native Semax, suggesting enhanced potency from the adamantane modification.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Behavioral studies in rodent models have shown improvements in spatial learning (radial arm maze), working memory (delayed match-to-sample), and attention (5-choice serial reaction time task) following Adamax administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e In ischemia-reperfusion models, Adamax has demonstrated reduced infarct volume and preserved neuronal density in the CA1 hippocampal region, with effects superior to those observed with native Semax at equivalent doses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic Enhancement:\u003c\/strong\u003e In-vivo distribution studies have confirmed increased CNS bioavailability of the adamantyl conjugate compared to unmodified Semax, with detectable peptide levels in cerebrospinal fluid at lower peripheral doses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAdamax\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying nootropic peptides and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/na-semax-amidate\"\u003eNA Semax Amidate\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Function Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420738249034,"sku":"PBL-ADAMAX-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-adamax-nootropic-peptide-10mg-research-grade.webp?v=1774393573","url":"https:\/\/peptides-biolab.com\/products\/adamax","provider":"Peptides BioLab","version":"1.0","type":"link"}