{"product_id":"adipotide","title":"Adipotide","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAdipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) — Proapoptotic Vascular-Targeting Peptide for Obesity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdipotide\u003c\/strong\u003e, also designated as Prohibitin-TP01, is a chimeric peptidomimetic composed of a vascular homing domain (CKGGRAKDC) linked to a proapoptotic sequence D(KLAKLAK)₂. Originally developed at the University of Texas MD Anderson Cancer Center and published by Kolonin et al. (2004) in \u003cem\u003eNature Medicine\u003c\/em\u003e, \u003cstrong\u003eAdipotide\u003c\/strong\u003e selectively targets prohibitin on the surface of blood vessels supplying white adipose tissue, inducing targeted apoptosis in adipose vasculature. This unique mechanism provides researchers with a tool for studying vascular-targeted approaches to adipose tissue remodeling.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eThe CKGGRAKDC motif of \u003cstrong\u003eAdipotide\u003c\/strong\u003e binds with high affinity to prohibitin, a receptor specifically expressed on the endothelial surface of white adipose tissue vasculature. Upon receptor binding, the conjugated D(KLAKLAK)₂ domain—a synthetic peptide engineered to disrupt mitochondrial membranes—is internalized into endothelial cells via receptor-mediated endocytosis. Once intracellular, the proapoptotic domain permeabilizes mitochondrial membranes, triggering cytochrome c release and caspase-mediated apoptosis selectively in adipose vascular endothelium.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargeted Adipose Ablation:\u003c\/strong\u003e In non-human primate studies published in \u003cem\u003eScience Translational Medicine\u003c\/em\u003e (2012), \u003cstrong\u003eAdipotide\u003c\/strong\u003e treatment resulted in significant dose-dependent reductions in body mass index, abdominal circumference, and total body fat measured by DEXA scanning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVascular Biology of Adipose Tissue:\u003c\/strong\u003e The compound has enabled researchers to map prohibitin expression patterns across different adipose depots, revealing heterogeneity in vascular surface receptor profiles between visceral and subcutaneous fat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Parameter Modulation:\u003c\/strong\u003e Preclinical studies observed improvements in insulin sensitivity and lipid profiles concurrent with adipose mass reduction, providing insights into the relationship between adipose vascularization and metabolic health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide-Drug Conjugate Design:\u003c\/strong\u003e Adipotide serves as a prototype for vascular-targeted peptide therapeutics, informing researchers designing next-generation tissue-selective delivery systems.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAdipotide\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying adipose biology and metabolic regulation may also find these compounds relevant: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/weight-loss\"\u003eWeight Loss Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737495370,"sku":"PBL-ADIPOTIDE-5MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-adipotide-peptide-5mg-research-grade.webp?v=1774393560","url":"https:\/\/peptides-biolab.com\/products\/adipotide","provider":"Peptides BioLab","version":"1.0","type":"link"}