{"product_id":"aicar","title":"Aicar","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAICAR — Cell-Permeable AMPK Activator for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAICAR\u003c\/strong\u003e (Acadesine) is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. First described by Corton et al. (1995), AICAR has become one of the most widely used pharmacological tools in metabolic research, spanning exercise physiology, glucose metabolism, and mitochondrial biogenesis.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eAICAR enters cells via adenosine transporters and is phosphorylated to ZMP, an AMP mimetic that binds the γ-subunit of AMPK, triggering allosteric activation. This shifts metabolism toward catabolic pathways — fatty acid oxidation, glucose uptake, mitochondrial biogenesis. Narkar et al. (2008, \u003cem\u003eCell\u003c\/em\u003e) showed AICAR increased running endurance by 44% in sedentary mice.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK Activation \u0026amp; Energy Sensing:\u003c\/strong\u003e Gold-standard pharmacological AMPK activator for studying energy depletion responses, mTOR suppression, and autophagy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Mimetic Research:\u003c\/strong\u003e Recapitulates molecular adaptations of endurance exercise: PGC-1α upregulation, mitochondrial biogenesis, slow-twitch fiber switching.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucose Metabolism:\u003c\/strong\u003e Increases GLUT4 translocation for insulin-independent glucose uptake in muscle cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipid Metabolism:\u003c\/strong\u003e Phosphorylates ACC, reducing malonyl-CoA and stimulating CPT1-dependent fatty acid oxidation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAICAR\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e, and \u003ca href=\"\/products\/slu-pp-322\"\u003eSLU-PP-332\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753083210,"sku":"PBL-AICAR-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-aicar-ampk-activator-50mg-research-grade.webp?v=1773935021","url":"https:\/\/peptides-biolab.com\/products\/aicar","provider":"Peptides BioLab","version":"1.0","type":"link"}