{"product_id":"aod9604","title":"AOD9604","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eAOD-9604 — Growth Hormone Fragment for Lipolytic Pathway Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAOD-9604\u003c\/strong\u003e is a modified 16-amino acid fragment (residues 177-191) of human growth hormone with an added N-terminal tyrosine. Developed at Monash University, it isolates GH lipolytic activity from growth-promoting and diabetogenic effects. Research in \u003cem\u003eObesity Research\u003c\/em\u003e (2001) showed it stimulates lipolysis and inhibits lipogenesis without affecting IGF-1 or insulin resistance.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eAOD-9604 activates beta-3 adrenergic receptor pathways, stimulating hormone-sensitive lipase (HSL) in adipocytes. It does not compete for GH receptor binding or stimulate IGF-1 secretion. Studies also showed stimulation of proteoglycan and collagen synthesis in chondrocyte models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipolysis \u0026amp; Adipocyte Biology:\u003c\/strong\u003e Stimulates lipolysis dose-dependently while inhibiting de novo lipogenesis in adipocyte cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Signaling Dissection:\u003c\/strong\u003e Enables study of GH lipolytic domain independently from somatotropic and diabetogenic pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCartilage Biology:\u003c\/strong\u003e Stimulates proteoglycan synthesis in bovine cartilage explants, investigated in osteoarthritis models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Pathway Analysis:\u003c\/strong\u003e Tool for investigating beta-3 adrenergic signaling, cAMP-PKA cascade, HSL and perilipin phosphorylation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eAOD-9604\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752788298,"sku":"PBL-AOD9604-6G","price":64.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-aod-9604-fat-loss-peptide-5mg-research-grade.webp?v=1773935013","url":"https:\/\/peptides-biolab.com\/products\/aod9604","provider":"Peptides BioLab","version":"1.0","type":"link"}