{"product_id":"ara-290","title":"Ara-290","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eARA-290 — Innate Repair Receptor Agonist for Neuroprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eARA-290\u003c\/strong\u003e (Cibinetide) is an 11-amino acid peptide derived from erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a heterocomplex of EPO receptor and CD131. Unlike EPO, it does not stimulate erythropoiesis. Published in \u003cem\u003eMolecular Medicine\u003c\/em\u003e (2008) by Brines et al.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eARA-290 binds the IRR heterocomplex, triggering JAK2\/STAT5 and PI3K\/Akt cascades that promote cell survival and modulate inflammatory cytokines. It suppresses NF-κB activation and reduces TNF-α, IL-6, IL-1β in macrophage models. In neural tissue, it protects against ischemia-reperfusion injury.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Promotes nerve fiber regeneration and restores sensory function in sciatic nerve injury models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory Signaling:\u003c\/strong\u003e Shifts macrophage polarization from M1 to M2 (reparative) phenotypes in chronic inflammation models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Neuropathy:\u003c\/strong\u003e Preserves intraepidermal nerve fiber density in diabetic neuropathy models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue-Protective Signaling:\u003c\/strong\u003e Activates cytoprotective pathways independent of erythropoiesis for clean tissue repair research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eARA-290\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ara-290\"\u003eARA-290\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751706954,"sku":"PBL-ARA-290-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ara-290-peptide-10mg-research-grade.webp?v=1773933873","url":"https:\/\/peptides-biolab.com\/products\/ara-290","provider":"Peptides BioLab","version":"1.0","type":"link"}