{"product_id":"bronchogen","title":"Bronchogen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eBronchogen (Ala-Glu-Asp) — Bronchial Bioregulator Peptide for Pulmonary Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eBronchogen\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Ala-Glu-Asp) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. This short peptide belongs to the Khavinson class of tissue-specific bioregulators that modulate gene expression through direct DNA interaction. Bronchogen has been specifically characterized for its regulatory effects on bronchial mucosa and respiratory epithelium, with research published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e documenting its capacity to normalize respiratory tissue function in aged and compromised animal models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBronchogen\u003c\/strong\u003e interacts with specific nucleotide sequences in promoter regions of genes expressed in bronchial epithelial tissue. This short bioregulator peptide penetrates cell membranes and binds the minor groove of double-stranded DNA, modulating chromatin accessibility and transcription factor binding at target gene loci. Research has demonstrated that Bronchogen upregulates the expression of surfactant proteins (SP-A, SP-D), mucin regulatory genes, and anti-inflammatory mediators in bronchial tissue cultures, while normalizing ciliary beat frequency in airway epithelial cell monolayers.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBronchial Epithelial Regeneration:\u003c\/strong\u003e Studies on human bronchial epithelial cell cultures have demonstrated that \u003cstrong\u003eBronchogen\u003c\/strong\u003e enhances proliferative capacity and restores tight junction protein expression (claudin-1, occludin) following chemical injury, suggesting accelerated mucosal barrier repair.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucociliary Function:\u003c\/strong\u003e Research in aged murine respiratory explants has shown normalization of ciliary beat frequency and mucus transport velocity following Bronchogen treatment, restoring parameters to levels observed in young control tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory Modulation:\u003c\/strong\u003e In-vitro studies have documented reduced IL-8 and TNF-α secretion from LPS-stimulated bronchial epithelial cells treated with Bronchogen, while preserving baseline immune surveillance capacity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Pulmonary Decline:\u003c\/strong\u003e Long-term studies in aged rodent models have observed preserved alveolar architecture and maintained gas exchange efficiency, with histological analysis showing reduced emphysematous changes compared to untreated controls.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Ala-Glu-Asp (AED tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 333.29 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eBronchogen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying Khavinson bioregulators and tissue repair may also find these compounds relevant: \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420760564042,"sku":"PBL-BRONCHOGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-bronchogen-bioregulator-peptide-10mg-research-grade.webp?v=1774393575","url":"https:\/\/peptides-biolab.com\/products\/bronchogen","provider":"Peptides BioLab","version":"1.0","type":"link"}