{"product_id":"cardiogen","title":"Cardiogen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCardiogen (Ala-Glu-Asp-Arg) — Cardiac Bioregulator Peptide for Cardiovascular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCardiogen\u003c\/strong\u003e is a synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Arg) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson's research group. As a cardiac-specific bioregulator, Cardiogen has been characterized for its regulatory effects on myocardial gene expression and cardiomyocyte function. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has demonstrated its capacity to normalize contractile function, restore metabolic enzyme expression, and promote cardiac tissue resilience in aged and ischemia-damaged myocardial models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCardiogen\u003c\/strong\u003e operates via the characteristic Khavinson bioregulator mechanism—direct interaction with specific DNA sequences to modulate gene transcription in target tissues. The AEDR tetrapeptide binds complementary nucleotide sequences in promoter regions of cardiac-specific genes, including those encoding myosin heavy chain isoforms, troponin complex subunits, and mitochondrial respiratory chain enzymes. Research has demonstrated selective upregulation of cardioprotective heat shock proteins (HSP70, HSP27) and anti-apoptotic Bcl-2 family members in cardiomyocyte cultures.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyocardial Protection:\u003c\/strong\u003e In-vitro studies on isolated cardiomyocyte preparations have demonstrated that \u003cstrong\u003eCardiogen\u003c\/strong\u003e preserves contractile function and reduces lactate dehydrogenase release following simulated ischemia-reperfusion injury, suggesting direct cardioprotective activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Aging:\u003c\/strong\u003e Research in aged rodent models has shown that Cardiogen administration restores myocardial compliance parameters, normalizes diastolic filling indices, and preserves mitochondrial ultrastructure in cardiac tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Normalization:\u003c\/strong\u003e Microarray analysis of Cardiogen-treated cardiac tissue has revealed restored expression of age-dysregulated genes involved in calcium handling (SERCA2a, phospholamban), energy metabolism (CPT-1, PDH), and antioxidant defense.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFibrosis Modulation:\u003c\/strong\u003e Histological studies have documented reduced interstitial fibrosis and preserved capillary density in aged myocardium following chronic Cardiogen treatment, correlating with maintained TGF-β1\/Smad signaling homeostasis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Ala-Glu-Asp-Arg (AEDR tetrapeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 489.48 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCardiogen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying cardiac bioregulation and cardiovascular peptides may also find these compounds relevant: \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420760793418,"sku":"PBL-CARDIOGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cardiogen-bioregulator-peptide-10mg-research-grade.webp?v=1774393577","url":"https:\/\/peptides-biolab.com\/products\/cardiogen","provider":"Peptides BioLab","version":"1.0","type":"link"}