{"product_id":"cartalax","title":"Cartalax","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCartalax (Ala-Glu-Asp) — Cartilage Bioregulator Peptide for Musculoskeletal Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCartalax\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Ala-Glu-Asp) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. While sharing the AED sequence with Bronchogen, Cartalax has been specifically characterized and optimized for its regulatory effects on cartilage tissue homeostasis and chondrocyte function. Published research has demonstrated its capacity to modulate extracellular matrix synthesis, normalize chondrocyte metabolism, and promote cartilage tissue resilience in both aged and mechanically stressed experimental models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCartalax\u003c\/strong\u003e interacts with DNA sequences in promoter regions of genes critical for cartilage extracellular matrix maintenance. The tripeptide modulates transcription of type II collagen (COL2A1), aggrecan (ACAN), and cartilage oligomeric matrix protein (COMP) through chromatin remodeling at chondrocyte-specific gene loci. Research has also demonstrated Cartalax-mediated upregulation of SOX9—the master transcription factor for chondrocyte phenotype maintenance—while reducing expression of catabolic enzymes including MMP-13 and ADAMTS-5 that drive cartilage matrix degradation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChondrocyte Metabolism:\u003c\/strong\u003e In-vitro studies on primary human articular chondrocytes have demonstrated that \u003cstrong\u003eCartalax\u003c\/strong\u003e increases glycosaminoglycan (GAG) synthesis rates and type II collagen deposition in three-dimensional pellet culture systems, with effects measurable by Alcian blue staining and hydroxyproline assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMatrix Protection:\u003c\/strong\u003e Research has shown that Cartalax reduces IL-1β-stimulated MMP-13 expression and aggrecan degradation fragment generation in cartilage explant cultures, suggesting anti-catabolic properties relevant to osteoarthritis research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStem Cell Chondrogenesis:\u003c\/strong\u003e Studies on mesenchymal stem cell differentiation have observed enhanced chondrogenic commitment when Cartalax is included in differentiation media, with increased SOX9 and COL2A1 expression compared to standard protocols.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Cartilage Changes:\u003c\/strong\u003e Histological analysis of articular cartilage from aged Cartalax-treated animals has shown preserved Safranin-O staining intensity, maintained cartilage thickness, and reduced surface fibrillation scores compared to untreated controls.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Ala-Glu-Asp (AED tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 333.29 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCartalax\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying cartilage biology and musculoskeletal repair may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420761776458,"sku":"PBL-CARTALAX-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cartalax-bioregulator-peptide-10mg-research-grade.webp?v=1774393586","url":"https:\/\/peptides-biolab.com\/products\/cartalax","provider":"Peptides BioLab","version":"1.0","type":"link"}