{"product_id":"chonluten","title":"Chonluten","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eChonluten (Glu-Asp-Gly) — Pulmonary\/Gastrointestinal Bioregulator for Mucosal Tissue Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eChonluten\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Glu-Asp-Gly) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson. This short bioregulator peptide has been characterized for its dual tissue specificity, demonstrating regulatory effects on both bronchial mucosal and gastrointestinal epithelial tissue gene expression. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its ability to normalize mucosal barrier function, restore epithelial turnover kinetics, and modulate local immune responses in both respiratory and digestive tract tissue models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eChonluten\u003c\/strong\u003e interacts with DNA sequences in promoter regions of genes governing mucosal epithelial integrity across multiple organ systems. The EDG tripeptide modulates transcription of tight junction proteins (ZO-1, claudins), mucin genes (MUC2, MUC5AC), and defensin antimicrobial peptides through chromatin remodeling at tissue-specific loci. Research has demonstrated that Chonluten simultaneously upregulates epithelial repair mechanisms while modulating the innate immune response at mucosal surfaces, maintaining the delicate balance between barrier defense and inflammatory control.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucosal Barrier Function:\u003c\/strong\u003e Trans-epithelial electrical resistance (TEER) measurements have demonstrated that \u003cstrong\u003eChonluten\u003c\/strong\u003e enhances barrier integrity in both Caco-2 intestinal monolayers and primary bronchial epithelial cell cultures, with significant upregulation of tight junction protein expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpithelial Regeneration:\u003c\/strong\u003e Wound healing assays on mucosal epithelial cell monolayers have shown accelerated gap closure and enhanced proliferative response following Chonluten treatment, with increased Ki-67 positivity and reduced apoptotic indices in the wound margin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucosal Immunity:\u003c\/strong\u003e Research has observed modulation of secretory IgA production and defensin expression at mucosal surfaces, suggesting that Chonluten supports local antimicrobial defense while preventing excessive inflammatory activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Mucosal Changes:\u003c\/strong\u003e Histological studies in aged animal gastrointestinal tissue have documented preserved villus height, maintained crypt depth ratio, and normalized goblet cell density following chronic Chonluten administration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Glu-Asp-Gly (EDG tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 319.27 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eChonluten\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying mucosal bioregulation may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e, and \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420761940298,"sku":"PBL-CHONLUTEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-chonluten-bioregulator-peptide-10mg-research-grade.webp?v=1774393588","url":"https:\/\/peptides-biolab.com\/products\/chonluten","provider":"Peptides BioLab","version":"1.0","type":"link"}