{"product_id":"cjc-1295-with-dac","title":"CJC-1295 With DAC","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCJC-1295 With DAC — Long-Acting GHRH Analog for Sustained GH Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e (Drug Affinity Complex) is a synthetic 30-amino acid peptide analog of growth hormone-releasing hormone (GHRH) conjugated to a maleimidopropionic acid–lysine linker that covalently binds to circulating albumin in vivo. Originally developed by ConjuChem Biotechnologies, this modification dramatically extends the compound's half-life from approximately 30 minutes (native GHRH) to 6–8 days, enabling sustained elevation of growth hormone and IGF-1 levels over prolonged periods. This pharmacokinetic profile makes \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e an essential tool for researchers studying chronic versus pulsatile somatotropic axis stimulation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e binds to the GHRH receptor (GHRH-R) on anterior pituitary somatotrophs, activating Gs-protein–coupled adenylyl cyclase signaling and elevating intracellular cAMP. This triggers PKA-dependent phosphorylation of CREB and subsequent transcription of the GH1 gene, promoting both GH synthesis and secretion. The DAC bioconjugation technology enables covalent binding to serum albumin (Lys-34), protecting the peptide from DPP-IV degradation and renal clearance. Published research in \u003cem\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism\u003c\/em\u003e (2006) demonstrated sustained GH elevation for 6+ days following a single dose, with 1.5–3 fold increases in mean IGF-1 concentrations.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSustained GH Elevation:\u003c\/strong\u003e Unlike pulsatile GH secretagogues, \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e produces continuous GH elevation, enabling researchers to compare chronic versus episodic somatotropic stimulation and their differential effects on IGF-1 generation, body composition, and tissue-specific gene expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 Axis Research:\u003c\/strong\u003e Studies have documented dose-dependent increases in circulating IGF-1 and IGFBP-3 levels sustained over 7–14 day periods, providing a unique model for studying prolonged IGF-1 signaling and its downstream metabolic effects in various tissue types.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBody Composition Studies:\u003c\/strong\u003e Preclinical research has demonstrated that chronic GHRH-R activation via CJC-1295 DAC leads to measurable changes in lean mass accretion and adipose tissue reduction, with investigators examining the interplay between sustained GH signaling and lipid metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic Modeling:\u003c\/strong\u003e The DAC bioconjugation technology has been studied as a platform for extending the half-life of therapeutic peptides, with CJC-1295 serving as a proof-of-concept model for albumin-binding prodrug strategies published in \u003cem\u003eBioconjugate Chemistry\u003c\/em\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCJC-1295 with DAC\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/cjc-1295-with-dac\"\u003eCJC-1295 with DAC\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying GHRH receptor pharmacology may also find these compounds relevant: \u003ca href=\"\/products\/cjc-1295-no-dac\"\u003eCJC-1295 No DAC\u003c\/a\u003e, \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, and \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647088458,"sku":"PBL-CJC1295-DAC-2MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cjc-1295-with-dac-2mg-research-grade.webp?v=1774393546","url":"https:\/\/peptides-biolab.com\/products\/cjc-1295-with-dac","provider":"Peptides BioLab","version":"1.0","type":"link"}