{"product_id":"cjc-1295-without-dac","title":"CJC 1295 without dac","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCJC-1295 Without DAC — Modified GHRH Analog for Pulsatile GH Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCJC-1295 Without DAC\u003c\/strong\u003e (Mod GRF 1-29) is a synthetic 29-amino acid GHRH analog with four substitutions (Ala2, Gln8, Ala15, Leu27) conferring DPP-IV resistance. Unlike the DAC version, it preserves natural pulsatile GH release, making it preferred for physiological GH secretion research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 Without DAC binds GHRH receptors on pituitary somatotrophs, activating the Gs-adenylyl cyclase-cAMP-PKA cascade for GH vesicle exocytosis. Half-life extended from ~7 min (native GRF 1-29) to 30+ min while maintaining pulsatile release kinetics essential for avoiding GH receptor desensitization.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulsatile GH Secretion:\u003c\/strong\u003e Stimulates somatotrophs without sustained elevation, preserving the ultradian rhythm of GH secretion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Secretagogue Research:\u003c\/strong\u003e Frequently combined with Ipamorelin — complementary GHRH + GHS-R pathways amplify GH release synergistically.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSomatotroph Cell Biology:\u003c\/strong\u003e Tool for investigating GHRH receptor signaling, cAMP response, and GH gene transcription.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDPP-IV Resistance Engineering:\u003c\/strong\u003e Model for studying how strategic amino acid substitutions extend peptide bioavailability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCJC-1295 Without DAC\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/cjc-1295-zonder-dac\"\u003eCJC-1295 Without DAC\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752984906,"sku":"PBL-CJC1295WITHOUTDAC-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-cjc-1295-without-dac-growth-hormone-peptide-5mg-research-grade.webp?v=1773935019","url":"https:\/\/peptides-biolab.com\/products\/cjc-1295-without-dac","provider":"Peptides BioLab","version":"1.0","type":"link"}