{"product_id":"crystagen","title":"Crystagen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eCrystagen (Glu-Asp-Pro) — Immune System Bioregulator for Immunological Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCrystagen\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Glu-Asp-Pro) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. This immune-specific bioregulator has been characterized for its regulatory effects on immunocompetent cell function, particularly lymphocyte differentiation, cytokine network balance, and innate immune surveillance capacity. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its ability to restore age-diminished immune parameters and normalize immune homeostasis in both in-vitro and in-vivo experimental systems.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCrystagen\u003c\/strong\u003e modulates gene expression in immunocompetent cells through the characteristic Khavinson bioregulator mechanism of direct DNA interaction. The EDP tripeptide binds specific nucleotide sequences in promoter regions of genes governing immune cell activation, differentiation, and effector function. Research has demonstrated modulation of cytokine gene expression profiles (IL-2, IFN-γ, IL-4, IL-10), normalization of T-helper 1\/T-helper 2 balance, and upregulation of pattern recognition receptor (TLR) expression on innate immune cells, collectively enhancing immune surveillance without promoting excessive inflammatory activation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLymphocyte Function:\u003c\/strong\u003e In-vitro studies on peripheral blood mononuclear cells (PBMCs) have demonstrated that \u003cstrong\u003eCrystagen\u003c\/strong\u003e enhances mitogen-stimulated lymphocyte proliferation, increases CD3+ T-cell activation markers (CD25, CD69), and restores age-diminished cytokine production capacity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInnate Immunity:\u003c\/strong\u003e Research has shown that Crystagen upregulates phagocytic activity of monocytes and neutrophils, enhances natural killer cell cytotoxicity against K562 target cells, and increases reactive oxygen species generation capacity in professional phagocytes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosenescence Reversal:\u003c\/strong\u003e Studies in aged rodent models have documented restoration of splenic T-cell zone architecture, normalization of naive\/memory T-cell ratios, and enhanced response to vaccination protocols following Crystagen treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCytokine Network Balance:\u003c\/strong\u003e Multiplex cytokine analysis has revealed that Crystagen normalizes the Th1\/Th2\/Th17\/Treg balance in aged immune systems, reducing excessive inflammatory cytokine production while preserving protective immune responses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Glu-Asp-Pro (EDP tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 359.33 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eCrystagen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying immune bioregulation may also find these compounds relevant: \u003ca href=\"\/products\/vilon\"\u003eVilon\u003c\/a\u003e, \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e, and \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420762071370,"sku":"PBL-CRYSTAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-crystagen-bioregulator-peptide-10mg-research-grade.webp?v=1774393590","url":"https:\/\/peptides-biolab.com\/products\/crystagen","provider":"Peptides BioLab","version":"1.0","type":"link"}