{"product_id":"follistatin-344","title":"Follistatin 344","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eFollistatin 344 — Activin-Binding Glycoprotein for Myostatin Antagonism Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFollistatin 344\u003c\/strong\u003e (FST344) is a 344-amino acid glycoprotein that antagonizes activin, myostatin (GDF-8), and other TGF-β superfamily ligands. Research in \u003cem\u003eFASEB Journal\u003c\/em\u003e (2005) showed dramatic skeletal muscle mass increases in multiple animal models.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eFollistatin neutralizes TGF-β members through direct protein-protein interactions. Its three FS domains create a binding surface complementary to activin and myostatin receptor-binding epitopes, preventing ActRII\/ALK4 activation and SMAD2\/3 signaling. PNAS research showed sustained muscle mass increases in non-human primate gene delivery models.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin Antagonism:\u003c\/strong\u003e Binds myostatin with nanomolar affinity, preventing ActRIIB signaling. Studied for effects on muscle fiber hypertrophy and satellite cell proliferation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivin Signaling:\u003c\/strong\u003e Regulates activin A\/B signaling influencing reproductive biology, inflammatory responses, and hepatic glucose metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Therapy Models:\u003c\/strong\u003e Used in AAV-mediated gene delivery for sustained muscle mass — proof-of-concept for neuromuscular gene therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Regeneration:\u003c\/strong\u003e Enhances satellite cell activation and myoblast fusion in damaged muscle tissue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eFollistatin 344\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e, \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752198474,"sku":"PBL-FOLLISTATIN344-6G","price":99.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-follistatin-344-myostatin-inhibitor-1mg-research-grade.webp?v=1773935005","url":"https:\/\/peptides-biolab.com\/products\/follistatin-344","provider":"Peptides BioLab","version":"1.0","type":"link"}