{"product_id":"foxo4-dri","title":"FOXO4-DRI","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eFOXO4-DRI — Senolytic Peptide for Cellular Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors in senescent cells. First described by Baar et al. (2017) in \u003cem\u003eCell\u003c\/em\u003e, this peptide selectively induces apoptosis in senescent cells by preventing FOXO4-mediated nuclear exclusion of p53, thereby restoring the cell's ability to undergo programmed cell death. As a targeted senolytic agent, \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e has become a pivotal research tool in the study of cellular senescence and age-related tissue dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e is engineered as a D-amino acid retro-inverso peptide, conferring exceptional proteolytic stability compared to native L-peptide sequences. In senescent cells, FOXO4 sequesters p53 in the nucleus through direct protein-protein interaction, preventing apoptotic signaling. FOXO4-DRI competitively binds FOXO4, disrupting this complex and allowing p53 to translocate to mitochondria, where it triggers caspase-dependent apoptosis. Crucially, this mechanism is selective for senescent cells—non-senescent cells with low FOXO4 expression remain unaffected.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular Senescence:\u003c\/strong\u003e Landmark research demonstrated that \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e selectively eliminates senescent cells in aged murine models, resulting in restoration of fur density, renal function, and physical performance parameters including running wheel activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSenescence-Associated Secretory Phenotype (SASP):\u003c\/strong\u003e By clearing senescent cells, FOXO4-DRI reduces the pro-inflammatory SASP milieu, which has been implicated in chronic tissue inflammation and age-related pathology progression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemotherapy-Induced Senescence:\u003c\/strong\u003e Preclinical models have demonstrated that FOXO4-DRI can mitigate doxorubicin-induced cellular senescence, a significant contributor to chemotherapy side effects and long-term tissue damage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Regeneration:\u003c\/strong\u003e Researchers have observed enhanced tissue repair capacity following senescent cell clearance, particularly in hepatic, renal, and dermal tissue models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide Type:\u003c\/strong\u003e D-retro-inverso modified peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/foxo4-dri\"\u003eFOXO4-DRI\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying senescence and aging pathways may also find these compounds relevant: \u003ca href=\"\/products\/epitalon\"\u003eEpitalon\u003c\/a\u003e, \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737364298,"sku":"PBL-FOXO4DRI-5MG","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-foxo4-dri-peptide-5mg-research-grade.webp?v=1774393557","url":"https:\/\/peptides-biolab.com\/products\/foxo4-dri","provider":"Peptides BioLab","version":"1.0","type":"link"}