{"product_id":"ghk-basic","title":"GHK Basic","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eGHK Basic — Tripeptide Growth Factor for Regenerative and Anti-Aging Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eGHK (Glycyl-L-Histidyl-L-Lysine)\u003c\/strong\u003e is a naturally occurring human tripeptide first identified by Pickart and Thaler in 1973 from human plasma. This simple three-amino acid sequence (Gly-His-Lys) was discovered through its ability to cause aged human liver tissue to synthesize proteins characteristic of younger tissue. Unlike its copper-bound form GHK-Cu, \u003cstrong\u003eGHK Basic\u003c\/strong\u003e is supplied without the copper ion, allowing researchers to control the metallopeptide chemistry of their experimental systems. GHK naturally chelates copper(II) with high affinity (log K = 16.44) and will readily form the GHK-Cu complex when copper is present, making this format ideal for studies requiring precise control over copper delivery and speciation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eGHK\u003c\/strong\u003e exerts broad biological effects through multiple mechanisms. Genomic studies published in \u003cem\u003eJournal of Biomedicine and Biotechnology\u003c\/em\u003e (2012) by Pickart et al. revealed that GHK modulates the expression of over 4,000 human genes, resetting gene expression patterns from aged profiles toward youthful configurations. Key pathways include upregulation of collagen synthesis genes (COL1A1, COL3A1), tissue inhibitors of metalloproteinases (TIMPs), and antioxidant response elements (Nrf2 pathway). GHK also stimulates decorin expression, which serves as a natural TGF-β trap, helping regulate fibrosis and tissue remodeling. Its copper-chelating function additionally supports the activity of copper-dependent enzymes including superoxide dismutase (SOD) and lysyl oxidase.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Reprogramming:\u003c\/strong\u003e Comprehensive microarray analyses have demonstrated that \u003cstrong\u003eGHK\u003c\/strong\u003e resets the expression of DNA repair genes, antioxidant genes, and stem cell-related genes toward patterns observed in younger tissues, providing a powerful model for studying the molecular mechanisms of tissue aging and rejuvenation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtracellular Matrix Biology:\u003c\/strong\u003e GHK has been shown to stimulate collagen, elastin, and glycosaminoglycan synthesis in fibroblast cultures while simultaneously enhancing the breakdown of large, cross-linked collagen aggregates through controlled MMP regulation, promoting organized tissue remodeling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetal Ion Biochemistry:\u003c\/strong\u003e The GHK Basic format enables researchers to study copper(II) chelation kinetics, metallopeptide formation constants, and the differential biological activity of apo-GHK versus holo-GHK-Cu complexes in controlled experimental settings.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing Models:\u003c\/strong\u003e Published studies have documented accelerated wound closure, enhanced angiogenesis, and improved tensile strength in dermal wound models treated with GHK, mediated through coordinated upregulation of growth factors including VEGF, FGF-2, and TGF-β1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eGHK Basic\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ghk-basic\"\u003eGHK Basic\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying copper peptide biology and tissue regeneration may also find these compounds relevant: \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, \u003ca href=\"\/products\/ahk-cu\"\u003eAHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420648169802,"sku":"PBL-GHK-BASIC-50MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ghk-basic-peptide-50mg-research-grade.webp?v=1774393553","url":"https:\/\/peptides-biolab.com\/products\/ghk-basic","provider":"Peptides BioLab","version":"1.0","type":"link"}