{"product_id":"hexarelin","title":"Hexarelin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eHexarelin — Potent Hexapeptide GH Secretagogue for Cardiac and Endocrine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHexarelin\u003c\/strong\u003e (Examorelin, His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH₂) is a synthetic hexapeptide growth hormone secretagogue that acts as a potent agonist of the GHS-R1a (ghrelin) receptor. Developed from the early GHRP series, Hexarelin distinguishes itself through its superior potency and unique dual activity profile: in addition to robust GH release from pituitary somatotrophs, it demonstrates significant cardioprotective effects mediated through both GHS-R1a-dependent and independent pathways. These properties, extensively documented by Ghigo et al. at the University of Turin, make \u003cstrong\u003eHexarelin\u003c\/strong\u003e a versatile research tool spanning endocrine, cardiovascular, and neuroprotective research domains.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHexarelin\u003c\/strong\u003e activates GHS-R1a receptors on anterior pituitary somatotrophs, triggering Gq\/11-mediated phospholipase C activation, IP3-dependent calcium mobilization, and subsequent GH exocytosis. Its GH-releasing potency exceeds that of GHRP-6 by approximately 1.5-fold on a molar basis. Uniquely, research published in \u003cem\u003eEndocrinology\u003c\/em\u003e (2000) identified that Hexarelin also binds CD36 (scavenger receptor class B), a mechanism that mediates its cardioprotective effects independently of GH secretion. This CD36-dependent pathway promotes fatty acid uptake, reduces foam cell formation, and activates PPARγ signaling in cardiac tissue.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Hormone Secretion:\u003c\/strong\u003e \u003cstrong\u003eHexarelin\u003c\/strong\u003e produces robust, dose-dependent GH release that is amplified when co-administered with GHRH. Studies in \u003cem\u003eEuropean Journal of Endocrinology\u003c\/em\u003e have characterized its secretory kinetics, desensitization profile, and utility as a provocative test agent for GH reserve assessment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardioprotection:\u003c\/strong\u003e Published research in \u003cem\u003eCardiovascular Research\u003c\/em\u003e (2003) demonstrated that Hexarelin reduces infarct size and improves post-ischemic cardiac function in Langendorff heart models, with effects mediated through CD36-dependent activation of PPARγ and suppression of NF-κB inflammatory signaling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Atherosclerotic Mechanisms:\u003c\/strong\u003e Through its CD36 binding activity, Hexarelin has been shown to modulate macrophage cholesterol efflux and inhibit oxidized LDL uptake, providing researchers with a unique pharmacological probe for studying scavenger receptor biology in atherosclerosis models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotective Research:\u003c\/strong\u003e Investigators have documented that Hexarelin protects hippocampal neurons from glutamate-induced excitotoxicity in vitro, with evidence suggesting both GHS-R1a-dependent and independent neuroprotective mechanisms involving PI3K\/Akt survival signaling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eHexarelin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/hexarelin\"\u003eHexarelin\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying GH secretagogues and cardiovascular peptide biology may also find these compounds relevant: \u003ca href=\"\/products\/ghrp-6\"\u003eGHRP-6\u003c\/a\u003e, \u003ca href=\"\/products\/ghrp-2\"\u003eGHRP-2\u003c\/a\u003e, and \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647383370,"sku":"PBL-HEXARELIN-5MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-hexarelin-peptide-5mg-research-grade.webp?v=1774393551","url":"https:\/\/peptides-biolab.com\/products\/hexarelin","provider":"Peptides BioLab","version":"1.0","type":"link"}