{"product_id":"hgh-fragment-176-191","title":"HGH Fragment 176-191","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eHGH Fragment 176-191 — Growth Hormone Lipolytic Domain for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e is a modified segment of the human growth hormone (hGH) molecule, corresponding to amino acids 176 through 191 of the C-terminal region. This peptide fragment retains the lipolytic activity of full-length hGH without its growth-promoting or diabetogenic properties. Research published by Ng et al. (2000) in \u003cem\u003eEndocrinology\u003c\/em\u003e first characterized this fragment's ability to stimulate lipolysis and inhibit lipogenesis in adipose tissue models, establishing it as a valuable research tool for studying fat metabolism independent of IGF-1 axis activation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e acts on adipocytes through a mechanism distinct from full-length growth hormone. While hGH stimulates lipolysis via JAK2\/STAT5 signaling, the 176-191 fragment appears to engage a beta-3 adrenergic receptor-mediated pathway, enhancing cyclic AMP production and activating hormone-sensitive lipase (HSL). Importantly, this fragment does not compete for GH receptor binding and does not stimulate IGF-1 secretion, providing researchers with a tool to study fat-specific metabolic effects in isolation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipolysis and Fat Metabolism:\u003c\/strong\u003e In-vitro studies on human and murine adipocytes have demonstrated that \u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e stimulates lipolysis at rates comparable to full-length hGH, while exhibiting no effect on longitudinal bone growth or glucose homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Lipogenic Activity:\u003c\/strong\u003e Research has shown this fragment inhibits de novo lipogenesis in adipocyte cultures, reducing fatty acid synthase (FAS) expression and decreasing triglyceride accumulation in dose-dependent fashion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Selectivity:\u003c\/strong\u003e Unlike full-length hGH, the 176-191 fragment does not impair insulin sensitivity in preclinical models, making it a tool for studying lipolytic pathways without confounding hyperglycemic effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity Research Models:\u003c\/strong\u003e Chronic administration studies in ob\/ob mouse models have demonstrated reductions in body fat percentage without changes in food intake or lean body mass.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eHGH Fragment 176-191\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying fat metabolism and growth hormone pathways may also find these compounds relevant: \u003ca href=\"\/products\/aod9604\"\u003eAOD-9604\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/weight-loss\"\u003eWeight Loss Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737397066,"sku":"PBL-HGHFRAG176-5MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-hgh-fragment-176-191-5mg-research-grade.webp?v=1774393558","url":"https:\/\/peptides-biolab.com\/products\/hgh-fragment-176-191","provider":"Peptides BioLab","version":"1.0","type":"link"}