{"product_id":"humanin","title":"Humanin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eHumanin — Mitochondrial-Derived Cytoprotective Peptide for Aging and Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHumanin\u003c\/strong\u003e is a 24-amino acid micropeptide encoded by the mitochondrial 16S ribosomal RNA gene (MT-RNR2). First discovered by Hashimoto et al. (2001) in \u003cem\u003eProceedings of the National Academy of Sciences\u003c\/em\u003e during a functional screen for neuroprotective factors, Humanin represents the first identified mitochondrial-derived peptide (MDP) with demonstrated cytoprotective activity. Its discovery opened an entirely new field of research into mitochondrial-encoded signaling molecules and their role in cellular stress response, aging, and metabolic regulation.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHumanin\u003c\/strong\u003e exerts its cytoprotective effects through multiple receptor-mediated and intracellular mechanisms. Extracellularly, it binds the trimeric receptor complex composed of CNTFR, WSX-1, and gp130, activating JAK2\/STAT3 signaling cascades that upregulate pro-survival gene expression. Humanin also binds IGFBP-3 and Bax protein intracellularly, preventing Bax-mediated mitochondrial membrane permeabilization and cytochrome c release. Additionally, it activates AMPK signaling and enhances mitochondrial bioenergetics through PGC-1α pathway modulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Research has demonstrated that \u003cstrong\u003eHumanin\u003c\/strong\u003e protects neurons against amyloid-β toxicity, glutamate excitotoxicity, and serum deprivation-induced apoptosis in primary cortical neuron cultures, with effective concentrations in the nanomolar range.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Biology:\u003c\/strong\u003e As the founding member of the MDP family, Humanin has enabled researchers to characterize mitochondrial-nuclear retrograde signaling pathways, revealing how mitochondrial genome-encoded peptides regulate cellular stress responses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Regulation:\u003c\/strong\u003e Studies in diet-induced obesity models have shown that Humanin improves insulin sensitivity, reduces hepatic gluconeogenesis, and enhances peripheral glucose uptake through AMPK-dependent mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging Biomarker:\u003c\/strong\u003e Circulating Humanin levels decline with age in multiple species, and epidemiological studies have correlated higher Humanin levels with improved metabolic parameters in elderly human cohorts, establishing it as a potential aging biomarker.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 5mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e MAPRGFSCLLLLTSEIDLPVKRRA (24 aa)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~2,687 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eHumanin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying mitochondrial peptides and cellular protection may also find these compounds relevant: \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e, \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e, and \u003ca href=\"\/products\/epitalon\"\u003eEpitalon\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e and \u003ca href=\"\/collections\/cellular-energy\"\u003eCellular Energy Research\u003c\/a\u003e collections.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420738085194,"sku":"PBL-HUMANIN-5MG","price":44.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-humanin-peptide-5mg-research-grade.webp?v=1774393571","url":"https:\/\/peptides-biolab.com\/products\/humanin","provider":"Peptides BioLab","version":"1.0","type":"link"}