{"product_id":"igf1-lr3","title":"IGF1-LR3","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eIGF-1 LR3 — Long-Acting Growth Factor Analog for Proliferation Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e is an 83-amino acid analog of human IGF-1 with reduced IGFBP binding (Arg3→Glu + 13-AA N-terminal extension), resulting in extended half-life and ~3× greater potency than native IGF-1 in cell proliferation assays.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIGF-1 LR3 activates IGF-1R, triggering PI3K\/Akt\/mTOR and Ras\/Raf\/MAPK cascades. Less than 1% affinity for IGFBP-3 keeps more peptide in active form. Standard component of serum-free culture media for myoblasts, fibroblasts, and stem cells.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Culture Applications:\u003c\/strong\u003e Standard growth supplement in serum-free media for myoblasts, fibroblasts, epithelial cells, and stem cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1R Signaling:\u003c\/strong\u003e Study receptor activation kinetics, PI3K\/Akt signaling, and sustained IGF-1R stimulation effects on cell cycle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle Cell Biology:\u003c\/strong\u003e Promotes myoblast proliferation, MyoD expression, and myotube formation in muscle cell cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGFBP-Independent Signaling:\u003c\/strong\u003e Reduced IGFBP binding enables clean analysis of receptor-level events without sequestration confounds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eIGF-1 LR3\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/igf1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e, \u003ca href=\"\/products\/follistatin-344\"\u003eFollistatin 344\u003c\/a\u003e, and \u003ca href=\"\/products\/ace-031\"\u003eACE-031\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752362314,"sku":"PBL-IGF1-LR3-6G","price":89.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-igf1-lr3-insulin-growth-factor-1mg-research-grade.webp?v=1773935008","url":"https:\/\/peptides-biolab.com\/products\/igf1-lr3","provider":"Peptides BioLab","version":"1.0","type":"link"}