{"product_id":"kisspeptin","title":"Kisspeptin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eKisspeptin-10 — KISS1R Agonist for Reproductive Neuroendocrinology Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKisspeptin-10\u003c\/strong\u003e is the C-terminal decapeptide of the KISS1 gene product, a critical HPG axis regulator. Identified as GPR54 ligand by de Roux et al. and Seminara et al. (2003, \u003cem\u003eNEJM\u003c\/em\u003e). Loss-of-function KISS1R mutations cause hypogonadotropic hypogonadism.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eKisspeptin-10 binds KISS1R (GPR54), a Gq\/11 receptor on GnRH neurons, triggering PLC-calcium mobilization and GnRH pulsatile secretion → LH and FSH release. Arcuate KNDy neurons generate the GnRH pulse essential for gonadotropin secretion.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGnRH Pulse Generator:\u003c\/strong\u003e Critical component of the GnRH pulse generator via arcuate KNDy neurons (kisspeptin + neurokinin B + dynorphin).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePuberty Research:\u003c\/strong\u003e Kisspeptin signaling increases dramatically at puberty — study neuroendocrine mechanisms of pubertal GnRH activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFertility and Ovulation:\u003c\/strong\u003e Triggers LH surges comparable to ovulation requirements, studying positive estrogen feedback on HPG axis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic-Reproductive Integration:\u003c\/strong\u003e Kisspeptin neurons receive leptin, insulin, and glucose inputs — nexus for energy-reproductive competence research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eKisspeptin-10\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/kisspeptin\"\u003eKisspeptin-10\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e, \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e, and \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eEndocrine Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995752886602,"sku":"PBL-KISSPEPTIN-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-kisspeptin-reproductive-peptide-5mg-research-grade.webp?v=1773935018","url":"https:\/\/peptides-biolab.com\/products\/kisspeptin","provider":"Peptides BioLab","version":"1.0","type":"link"}