{"product_id":"kpv","title":"KPV","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eKPV — Alpha-MSH C-Terminal Tripeptide for Anti-Inflammatory Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKPV\u003c\/strong\u003e (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH, retaining anti-inflammatory properties without melanocortin receptor-mediated melanogenic activity. Characterized by Brzoska et al. (\u003cem\u003eFEBS Letters\u003c\/em\u003e, 1999).\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eKPV inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation, suppressing IL-1β, IL-6, and TNF-α. Enters cells directly for receptor-independent effects. Reduces inflammation in colitis models through direct intestinal epithelial cell signaling (\u003cem\u003eJ Immunol\u003c\/em\u003e). Modulates NLRP3 inflammasome.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNF-κB Pathway:\u003c\/strong\u003e Inhibits NF-κB at multiple cascade points without broad receptor pharmacology of full-length α-MSH.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntestinal Inflammation:\u003c\/strong\u003e Demonstrated anti-inflammatory effects in DSS-colitis and IBD models with reduced mucosal damage and neutrophil infiltration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Inflammation:\u003c\/strong\u003e Reduces IL-8 and TNF-α in UV-irradiated and LPS-stimulated skin cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInnate Immune Modulation:\u003c\/strong\u003e Modulates macrophage and dendritic cell inflammatory responses while preserving antimicrobial functions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eKPV\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eImmunomodulatory Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751772490,"sku":"PBL-KPV-6G","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-kpv-anti-inflammatory-peptide-10mg-research-grade.webp?v=1773933883","url":"https:\/\/peptides-biolab.com\/products\/kpv","provider":"Peptides BioLab","version":"1.0","type":"link"}