{"product_id":"livagen","title":"Livagen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eLivagen (Lys-Glu-Ala-Ser) — Hepatic Bioregulator Peptide for Liver Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLivagen\u003c\/strong\u003e is a synthetic tetrapeptide bioregulator (Lys-Glu-Ala-Ser) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson. This liver-specific bioregulator has been extensively characterized for its capacity to modulate hepatocyte gene expression, restore liver detoxification enzyme activity, and normalize hepatic regenerative capacity in aged and chemically challenged liver tissue models. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its unique mechanism of chromatin decondensation in hepatocyte nuclei.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eLivagen\u003c\/strong\u003e represents one of the most thoroughly studied Khavinson bioregulators at the molecular level. The KEAS tetrapeptide has been demonstrated to induce decondensation of heterochromatin in hepatocyte nuclei, reactivating previously silenced gene regions. Specifically, research using atomic force microscopy and FISH analysis has shown that Livagen promotes unfolding of pericentromeric satellite DNA regions, increasing transcriptional accessibility at loci encoding cytochrome P450 enzymes (CYP1A2, CYP3A4), glutathione S-transferase isoforms, and albumin synthesis machinery.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChromatin Remodeling:\u003c\/strong\u003e Landmark studies have demonstrated that \u003cstrong\u003eLivagen\u003c\/strong\u003e induces measurable chromatin decondensation in hepatocyte nuclei within hours of treatment, increasing the proportion of transcriptionally active euchromatin—a finding confirmed by both DAPI staining and DNase I hypersensitivity assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic Detoxification:\u003c\/strong\u003e Research has shown normalization of cytochrome P450 enzyme activity profiles in aged hepatocyte cultures, with significant restoration of CYP1A2 and CYP3A4 catalytic capacity following Livagen treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver Regeneration:\u003c\/strong\u003e Partial hepatectomy models have demonstrated enhanced regenerative response in Livagen-pretreated animals, with increased hepatocyte proliferation rates (Ki-67 positivity) and preserved lobular architecture during regrowth.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatoprotection:\u003c\/strong\u003e Studies in CCl₄-induced liver injury models have shown reduced transaminase elevation, decreased oxidative stress markers (MDA, 4-HNE), and preserved glutathione reserves following Livagen administration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu-Ala-Ser (KEAS tetrapeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 433.46 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eLivagen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying hepatic bioregulation and liver biology may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e, and \u003ca href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420761186634,"sku":"PBL-LIVAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-livagen-bioregulator-peptide-10mg-research-grade.webp?v=1774393581","url":"https:\/\/peptides-biolab.com\/products\/livagen","provider":"Peptides BioLab","version":"1.0","type":"link"}