{"product_id":"ll-37","title":"LL-37","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eLL-37 — Human Cathelicidin Antimicrobial Peptide for Innate Immunity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLL-37\u003c\/strong\u003e is a 37-amino acid cationic antimicrobial peptide — the only human cathelicidin. Cleaved from hCAP18 by proteinase 3, it adopts an amphipathic alpha-helix for membrane disruption. Sequenced by Gudmundsson et al. (1996). Active against bacteria, fungi, and enveloped viruses.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eLL-37 disrupts microbial membranes through electrostatic attraction to anionic phospholipids via carpet model, toroidal pore, and membrane thinning mechanisms. Also activates FPRL1, promotes chemotaxis, stimulates angiogenesis, and modulates TLR signaling. Forms DNA complexes activating dendritic cells via TLR9 (\u003cem\u003eNature Medicine\u003c\/em\u003e).\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntimicrobial Mechanisms:\u003c\/strong\u003e Broad-spectrum activity against Gram+\/- bacteria, fungi, viruses. Physical mode of action resists pathogen adaptation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInnate Immune Signaling:\u003c\/strong\u003e Activates FPRL1, P2X7, EGFR, triggering chemotaxis and cytokine responses bridging innate and adaptive immunity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing:\u003c\/strong\u003e EGFR transactivation stimulates keratinocyte migration for re-epithelialization.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiofilm Research:\u003c\/strong\u003e Anti-biofilm activity at sub-MIC concentrations against P. aeruginosa and S. aureus.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eLL-37\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eImmunomodulatory Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751739722,"sku":"PBL-LL-37-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ll-37-antimicrobial-peptide-5mg-research-grade.webp?v=1773933885","url":"https:\/\/peptides-biolab.com\/products\/ll-37","provider":"Peptides BioLab","version":"1.0","type":"link"}