{"product_id":"mots-c","title":"MOTS-C","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMOTS-c — Mitochondrial-Derived Peptide for Metabolic Reprogramming Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMOTS-c\u003c\/strong\u003e is a 16-amino acid mitochondrial-encoded peptide discovered by Lee et al. at USC (\u003cem\u003eCell Metabolism\u003c\/em\u003e, 2015). One of the first mitochondrial-derived peptides (MDPs) with systemic signaling, representing a novel class of retrograde signaling molecules.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMOTS-c translocates to the nucleus under metabolic stress, regulating AMPK-dependent transcription. It inhibits the folate-methionine cycle through AICAR accumulation, mimicking caloric restriction. Circulating levels decline with age, correlating with metabolic dysfunction.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitohormesis \u0026amp; Retrograde Signaling:\u003c\/strong\u003e Paradigm of mitochondria-to-nucleus peptide communication coordinating metabolic adaptation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK Activation:\u003c\/strong\u003e Unique activation via folate cycle modulation — distinct from classical AMPK activators.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise Physiology:\u003c\/strong\u003e Levels increase during exercise; enhances exercise capacity in aged mice, mediating metabolic benefits of activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Longevity:\u003c\/strong\u003e Declining levels correlate with aging; investigated for reversing insulin resistance and mitochondrial dysfunction.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMOTS-c\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e, \u003ca href=\"\/products\/5-amino1-mq\"\u003e5-Amino-1MQ\u003c\/a\u003e, and \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eMetabolic Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"10","offer_id":60995753247050,"sku":"PBL-MOTS-C-10MG","price":49.99,"currency_code":"EUR","in_stock":true},{"title":"40","offer_id":60995753279818,"sku":"PBL-MOTS-C-10MG","price":179.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mots-c-mitochondrial-peptide-10mg-research-grade.webp?v=1773935026","url":"https:\/\/peptides-biolab.com\/products\/mots-c","provider":"Peptides BioLab","version":"1.0","type":"link"}