{"product_id":"mt-1-melanotan-1","title":"MT-1 (Melanotan 1)","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eMT-1 (Melanotan 1) — Alpha-MSH Analog for Dermatological and Photoprotection Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMT-1 (Melanotan 1)\u003c\/strong\u003e, also known as Afamelanotide, is a synthetic tridecapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). First developed at the University of Arizona in the 1980s by Hruby and Hadley, this linear peptide binds with high selectivity to the melanocortin 1 receptor (MC1R), making it a valuable research tool for investigating melanogenesis, photoprotection pathways, and UV-induced DNA damage repair mechanisms. Unlike its cyclic counterpart Melanotan II, \u003cstrong\u003eMT-1\u003c\/strong\u003e demonstrates preferential MC1R selectivity with minimal cross-reactivity at MC3R, MC4R, and MC5R subtypes.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMelanotan 1\u003c\/strong\u003e activates the MC1R signaling cascade in melanocytes, stimulating adenylyl cyclase activity and increasing intracellular cAMP concentrations. This triggers CREB-mediated transcription of the MITF (microphthalmia-associated transcription factor) gene, which subsequently upregulates tyrosinase, TRP-1, and TRP-2 enzymes essential for eumelanin biosynthesis. Research published in \u003cem\u003eFASEB Journal\u003c\/em\u003e (2005) demonstrated that MC1R activation by α-MSH analogs also enhances nucleotide excision repair (NER) of cyclobutane pyrimidine dimers, independent of pigmentation effects, suggesting dual protective mechanisms against UV-induced mutagenesis.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanogenesis Pathways:\u003c\/strong\u003e In-vitro studies using human melanocyte cultures have demonstrated that \u003cstrong\u003eMT-1\u003c\/strong\u003e induces dose-dependent increases in eumelanin production through MC1R-cAMP-MITF signaling, providing researchers with a selective pharmacological tool for studying pigmentation biology.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoprotection Research:\u003c\/strong\u003e Published clinical studies in \u003cem\u003eThe New England Journal of Medicine\u003c\/em\u003e (2015) investigated MT-1 in the context of erythropoietic protoporphyria (EPP), demonstrating increased pain-free sun exposure duration and melanin density in treated subjects, establishing a model for photoprotective compound evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDNA Damage Repair:\u003c\/strong\u003e Research has shown that MC1R signaling activated by MT-1 enhances the repair of UV-induced DNA photoproducts through cAMP-dependent upregulation of XPC and DDB2 nucleotide excision repair proteins, independent of melanin production.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Biology Models:\u003c\/strong\u003e Investigators have utilized MT-1 in 3D skin equivalent models and organotypic cultures to study melanocyte-keratinocyte crosstalk, melanosome transfer dynamics, and the paracrine effects of melanocortin signaling on surrounding cell populations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eMT-1 (Melanotan 1)\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/mt-1-melanotan-1\"\u003eMT-1\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying melanocortin receptor signaling and dermatological pathways may also find these compounds relevant: \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e, \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/sexual-health\"\u003eSexual Health Research\u003c\/a\u003e and \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collections.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646465866,"sku":"PBL-MT1-10MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-mt-1-melanotan-1-10mg-research-grade.webp?v=1774393539","url":"https:\/\/peptides-biolab.com\/products\/mt-1-melanotan-1","provider":"Peptides BioLab","version":"1.0","type":"link"}