{"product_id":"n-acetyl-epitalon-amidate","title":"N-Acetyl Epitalon Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eN-Acetyl Epitalon Amidate — Enhanced Telomerase-Activating Peptide for Longevity Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Epitalon Amidate\u003c\/strong\u003e is a pharmacologically optimized derivative of Epitalon (Epithalon), the synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. This modified form features N-terminal acetylation and C-terminal amidation, conferring significantly enhanced metabolic stability and bioavailability compared to native Epitalon. The parent compound was first described for its telomerase-activating properties in research published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2003).\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Epitalon Amidate\u003c\/strong\u003e activates telomerase reverse transcriptase (hTERT) gene expression, the catalytic subunit responsible for telomere elongation. The N-acetyl modification protects against aminopeptidase degradation, while C-terminal amidation increases receptor binding affinity and resistance to carboxypeptidases. Research has demonstrated that Epitalon-class peptides interact with DNA regions upstream of the hTERT promoter, modulating transcription factor binding and chromatin accessibility. Additionally, the compound influences pineal gland melatonin synthesis through neuroendocrine pathway modulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTelomerase Activation:\u003c\/strong\u003e Studies on human somatic cell cultures have demonstrated that Epitalon peptides reactivate telomerase in senescent fibroblasts, extending replicative lifespan beyond the Hayflick limit while maintaining chromosomal stability and normal karyotype.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePineal Function and Circadian Biology:\u003c\/strong\u003e Research in aged rodent models has shown that Epitalon administration restores circadian melatonin secretion patterns, normalizes pineal gland morphology, and modulates suprachiasmatic nucleus output.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhanced Pharmacokinetics:\u003c\/strong\u003e The N-acetyl amidated form demonstrates a significantly longer plasma half-life compared to native Epitalon, with studies reporting 3-5x greater stability in serum degradation assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant Gene Expression:\u003c\/strong\u003e Published data indicates upregulation of superoxide dismutase (SOD) and catalase expression following treatment, suggesting enhanced endogenous antioxidant defense capacity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 20mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Ac-Ala-Glu-Asp-Gly-NH₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eN-Acetyl Epitalon Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying telomere biology and longevity may also find these compounds relevant: \u003ca href=\"\/products\/epitalon\"\u003eEpitalon\u003c\/a\u003e, \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/anti-aging\"\u003eAnti-Aging Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737528138,"sku":"PBL-NAEPITALON-20MG","price":49.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-n-acetyl-epitalon-amidate-20mg-research-grade.webp?v=1774393562","url":"https:\/\/peptides-biolab.com\/products\/n-acetyl-epitalon-amidate","provider":"Peptides BioLab","version":"1.0","type":"link"}