{"product_id":"na-selank-amidate","title":"NA Selank Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Selank Amidate — Stabilized Anxiolytic Neuropeptide for Cognitive and Immunomodulatory Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Selank Amidate\u003c\/strong\u003e is a modified analog of Selank, the synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been extensively studied for its anxiolytic, nootropic, and immunostimulatory properties. The N-acetyl amidate modification confers superior enzymatic stability by protecting both the N-terminal (via acetylation) and C-terminal (via amidation) from exopeptidase degradation, resulting in significantly enhanced bioavailability and prolonged biological activity in research applications.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e modulates the GABAergic system by allosterically influencing GABA-A receptor sensitivity, without directly binding the benzodiazepine site. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e (2008) demonstrated that Selank analogs increase BDNF (brain-derived neurotrophic factor) mRNA expression in the hippocampus and frontal cortex, promoting neuroplasticity. Additionally, the compound has been shown to modulate the expression of IL-6, IL-10, and TNF-α, suggesting dual neuroimmune regulatory activity. The stabilized form enhances these effects by maintaining effective concentrations over extended experimental timeframes.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnxiolytic Mechanisms:\u003c\/strong\u003e In behavioral models (elevated plus maze, open field test), \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e has demonstrated anxiolytic effects comparable to benzodiazepines without sedation, motor impairment, or dependence potential. Studies in \u003cem\u003eBehavioural Brain Research\u003c\/em\u003e (2009) documented significant reductions in anxiety-like behavior in rodent models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Research has shown that Selank analogs enhance memory consolidation and retrieval in passive avoidance and Morris water maze paradigms, mediated through increased BDNF expression and enhanced monoamine neurotransmitter metabolism in hippocampal and prefrontal regions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e As a tuftsin analog, NA Selank Amidate stimulates phagocytic activity and modulates cytokine profiles. Published studies have documented increased natural killer cell activity and balanced Th1\/Th2 immune responses in treated animal models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Investigators have examined the compound's ability to protect neurons from oxidative stress-induced apoptosis, with evidence of enhanced SOD activity and reduced lipid peroxidation markers in cortical neuron cultures following treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Selank Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-selank-amidate\"\u003eNA Selank Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying anxiolytic neuropeptides and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646629706,"sku":"PBL-NA-SELANK-AMIDATE-30MG","price":69.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-selank-amidate-30mg-research-grade.webp?v=1774393541","url":"https:\/\/peptides-biolab.com\/products\/na-selank-amidate","provider":"Peptides BioLab","version":"1.0","type":"link"}