{"product_id":"na-semax-amidate","title":"NA Semax Amidate","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eNA Semax Amidate — Enhanced ACTH Analog for Neurotrophic and Cerebrovascular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Semax Amidate\u003c\/strong\u003e is a stabilized derivative of Semax, the synthetic heptapeptide analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied extensively for its pronounced neurotrophic, neuroprotective, and cognitive-enhancing properties. The N-acetyl amidate modification significantly increases the peptide's resistance to aminopeptidase and carboxypeptidase degradation, resulting in an extended half-life and enhanced potency compared to the parent compound in research settings.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e exerts its effects through multiple converging pathways. Research published in \u003cem\u003eNeuroscience Letters\u003c\/em\u003e (2006) demonstrated that Semax analogs rapidly upregulate BDNF and NGF (nerve growth factor) expression in cortical and hippocampal tissues through TrkB receptor-mediated signaling cascades. The compound also modulates dopaminergic and serotoninergic neurotransmission, increasing dopamine and serotonin turnover in the striatum and nucleus accumbens. Additionally, published data in \u003cem\u003eDoklady Biological Sciences\u003c\/em\u003e have shown that Semax analogs influence gene expression patterns related to neurovascular coupling and cerebral blood flow autoregulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurotrophic Factor Expression:\u003c\/strong\u003e In-vitro and in-vivo studies have demonstrated that \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e upregulates BDNF, NGF, and NT-3 expression in glial and neuronal cell populations. Research in \u003cem\u003eBrain Research\u003c\/em\u003e (2007) documented a 2-3 fold increase in BDNF mRNA levels in the hippocampus following administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Performance:\u003c\/strong\u003e Behavioral studies using novel object recognition, radial arm maze, and contextual fear conditioning paradigms have shown significant enhancements in learning acquisition and memory retention in rodent models treated with Semax analogs, with the stabilized form demonstrating prolonged effect duration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCerebrovascular Research:\u003c\/strong\u003e Investigators have studied the compound's effects on cerebral hemodynamics, documenting improved cerebral blood flow autoregulation and reduced infarct volume in models of focal cerebral ischemia, mediated through NO-dependent vasodilation and neurovascular unit protection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroinflammation:\u003c\/strong\u003e Research has demonstrated that NA Semax Amidate modulates microglial activation states, promoting the M2 anti-inflammatory phenotype while attenuating pro-inflammatory cytokine release (IL-1β, TNF-α) in lipopolysaccharide-challenged neuronal co-cultures.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eNA Semax Amidate\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/na-semax-amidate\"\u003eNA Semax Amidate\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying neurotrophic signaling and cognitive enhancement may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/dihexa\"\u003eDihexa\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420646793546,"sku":"PBL-NA-SEMAX-AMIDATE-30MG","price":79.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-na-semax-amidate-30mg-research-grade.webp?v=1774393542","url":"https:\/\/peptides-biolab.com\/products\/na-semax-amidate","provider":"Peptides BioLab","version":"1.0","type":"link"}