{"product_id":"ovagen","title":"Ovagen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eOvagen (Glu-Asp-Leu) — Hepato-Gastrointestinal Bioregulator for Digestive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eOvagen\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Glu-Asp-Leu) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson. Originally derived from research on hepatic and gastrointestinal tissue extracts, Ovagen has been characterized for its dual regulatory effects on liver function and gastrointestinal epithelial homeostasis. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its capacity to normalize digestive enzyme secretion, restore hepatobiliary function, and support mucosal integrity across the gastrointestinal tract in aged experimental models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eOvagen\u003c\/strong\u003e interacts with DNA sequences in promoter regions of genes governing both hepatocyte function and gastrointestinal epithelial differentiation. The EDL tripeptide modulates transcription of key digestive enzymes, bile acid transport proteins (BSEP, MRP2), and intestinal epithelial differentiation markers through chromatin remodeling. Research has demonstrated simultaneous normalization of hepatic phase I\/II detoxification enzyme expression and intestinal brush border enzyme activity (alkaline phosphatase, sucrase-isomaltase), suggesting a coordinated regulatory effect across the digestive axis.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatobiliary Function:\u003c\/strong\u003e In-vitro studies on primary hepatocyte cultures have demonstrated that \u003cstrong\u003eOvagen\u003c\/strong\u003e normalizes bile acid synthesis enzyme expression (CYP7A1, CYP27A1) and enhances canalicular transport protein activity, improving bile flow parameters in perfused liver preparations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal Epithelial Renewal:\u003c\/strong\u003e Research on intestinal organoid cultures has shown enhanced crypt cell proliferation and accelerated differentiation into absorptive enterocytes and goblet cells following Ovagen treatment, with preserved stem cell niche integrity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Enzyme Regulation:\u003c\/strong\u003e Studies have documented normalized pancreatic exocrine enzyme secretion (amylase, lipase, trypsin) and gastric acid output in aged animal models, restoring digestive efficiency to levels approaching younger controls.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGut-Liver Axis:\u003c\/strong\u003e Research has explored Ovagen's effects on the gut-liver axis, documenting improved intestinal barrier function (reduced plasma endotoxin levels) concurrent with enhanced hepatic clearance capacity in aged animal models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Glu-Asp-Leu (EDL tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 375.37 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eOvagen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying digestive bioregulation may also find these compounds relevant: \u003ca href=\"\/products\/livagen\"\u003eLivagen\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/kpv\"\u003eKPV\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420762267978,"sku":"PBL-OVAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-ovagen-bioregulator-peptide-10mg-research-grade.webp?v=1774393591","url":"https:\/\/peptides-biolab.com\/products\/ovagen","provider":"Peptides BioLab","version":"1.0","type":"link"}