{"product_id":"p21","title":"P21","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eP21 (P021) — CNTF-Derived Neurotrophic Peptide for Neurogenesis Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eP21\u003c\/strong\u003e, also known as P021, is an 11-mer synthetic peptide derived from the ciliary neurotrophic factor (CNTF) active region, developed by Dr. Khalid Iqbal's group at the New York State Institute for Basic Research in Developmental Disabilities. Published in \u003cem\u003eNeurobiology of Aging\u003c\/em\u003e (2013) and \u003cem\u003eJournal of Alzheimer's Disease\u003c\/em\u003e, P21 was designed to mimic CNTF's neurotrophic properties while possessing enhanced blood-brain barrier permeability and oral bioavailability. This compound has emerged as a key research tool for studying adult hippocampal neurogenesis and synaptic plasticity.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eP21\u003c\/strong\u003e enhances the expression of brain-derived neurotrophic factor (BDNF) through inhibition of leukemia inhibitory factor (LIF) signaling. By competitively binding the LIF receptor without activating downstream JAK\/STAT signaling, P21 releases tonic inhibition on BDNF transcription. Elevated BDNF subsequently activates TrkB receptor cascades, promoting neuronal survival, dendritic arborization, and synaptic strengthening. Additionally, P21 has been shown to decrease glycogen synthase kinase 3β (GSK-3β) activity, reducing tau hyperphosphorylation in neuronal culture models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdult Neurogenesis:\u003c\/strong\u003e Studies using BrdU-labeled neuronal progenitors in aged mouse hippocampus have demonstrated that \u003cstrong\u003eP21\u003c\/strong\u003e significantly increases neurogenesis in the subgranular zone of the dentate gyrus, with newly generated neurons exhibiting mature electrophysiological properties.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement:\u003c\/strong\u003e Morris water maze and novel object recognition studies in 3xTg-AD mouse models have shown significant improvements in spatial and recognition memory following chronic P21 administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTau Pathology:\u003c\/strong\u003e Research has demonstrated that P21 reduces phosphorylated tau levels at multiple epitopes (AT8, PHF-1, AT180) in transgenic Alzheimer's disease models, correlating with improved synaptic density markers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynaptic Plasticity:\u003c\/strong\u003e Electrophysiological studies have shown enhanced long-term potentiation (LTP) in hippocampal slices from P21-treated animals, with increased expression of synaptic scaffold proteins PSD-95 and synaptophysin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 50mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eP21\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying neurogenesis and cognitive function may also find these compounds relevant: \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eCognitive Function Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737954122,"sku":"PBL-P21-50MG","price":59.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-p21-nootropic-peptide-50mg-research-grade.webp?v=1774393569","url":"https:\/\/peptides-biolab.com\/products\/p21","provider":"Peptides BioLab","version":"1.0","type":"link"}