{"product_id":"pancragen","title":"Pancragen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePancragen (Lys-Glu-Asp-Trp) — Pancreatic Bioregulator Peptide for Metabolic Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePancragen\u003c\/strong\u003e is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Trp) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. As a pancreas-specific bioregulator, Pancragen has been characterized for its selective modulatory effects on pancreatic islet cell gene expression, insulin secretion dynamics, and beta cell resilience. Research published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has documented its capacity to normalize glycemic regulation parameters and preserve islet architecture in aged and metabolically stressed animal models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePancragen\u003c\/strong\u003e interacts with specific DNA sequences in promoter regions of genes critical for pancreatic islet function. The KEDW tetrapeptide modulates chromatin accessibility at loci encoding insulin (INS gene), glucokinase (GCK), pancreatic duodenal homeobox-1 (PDX-1), and glucose transporter type 2 (GLUT2). Research has demonstrated that Pancragen restores age-diminished PDX-1 expression—the master transcription factor for beta cell identity and insulin gene transcription—in aged islet preparations, effectively reprogramming metabolic sensing capacity.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBeta Cell Function:\u003c\/strong\u003e In-vitro glucose-stimulated insulin secretion (GSIS) assays have demonstrated that \u003cstrong\u003ePancragen\u003c\/strong\u003e restores first-phase insulin release kinetics in aged murine islets, normalizing the biphasic secretion pattern characteristic of healthy beta cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIslet Preservation:\u003c\/strong\u003e Histological studies in aged rodent pancreatic tissue have shown maintained islet size distribution, preserved alpha\/beta cell ratio, and reduced amyloid deposition following chronic Pancragen treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Gene Expression:\u003c\/strong\u003e Transcriptomic analysis of Pancragen-treated islets has revealed normalized expression of key metabolic sensors including GCK, KATP channel subunits (SUR1\/Kir6.2), and voltage-gated calcium channels essential for stimulus-secretion coupling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular Energy Metabolism:\u003c\/strong\u003e Research has demonstrated enhanced mitochondrial membrane potential and ATP production in beta cells treated with Pancragen, improving the metabolic coupling efficiency between glucose sensing and insulin exocytosis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu-Asp-Trp (KEDW tetrapeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 562.57 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePancragen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying pancreatic bioregulation and metabolic pathways may also find these compounds relevant: \u003ca href=\"\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e, \u003ca href=\"\/products\/ss-31\"\u003eSS-31\u003c\/a\u003e, and \u003ca href=\"\/products\/aicar\"\u003eAICAR\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/cellular-energy\"\u003eCellular Energy Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420761383242,"sku":"PBL-PANCRAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pancragen-bioregulator-peptide-10mg-research-grade.webp?v=1774393582","url":"https:\/\/peptides-biolab.com\/products\/pancragen","provider":"Peptides BioLab","version":"1.0","type":"link"}