{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePE-22-28 — Spadin-Derived Peptide for TREK-1 Channel Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePE-22-28\u003c\/strong\u003e is a synthetic heptapeptide from sortilin propeptide (spadin), selectively antagonizing TREK-1 potassium channels. Identified by Mazella et al. (\u003cem\u003ePNAS\u003c\/em\u003e, 2010). TREK-1 channels are highly expressed in hippocampus and cortex, regulating mood and cognition.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePE-22-28 selectively blocks TREK-1 (KCNK2), increasing neuronal firing and synaptic transmission. TREK-1 knockout mice show enhanced hippocampal neurogenesis and BDNF signaling (\u003cem\u003eBiological Psychiatry\u003c\/em\u003e). PE-22-28 recapitulates these effects: increased neurogenesis, enhanced 5-HT neurotransmission, CREB\/BDNF upregulation.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTREK-1 Channel Research:\u003c\/strong\u003e Selective pharmacological tool for studying TREK-1 influence on membrane excitability and synaptic plasticity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHippocampal Neurogenesis:\u003c\/strong\u003e Increased neural progenitor proliferation in dentate gyrus with promoted survival and neuronal differentiation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF Signaling:\u003c\/strong\u003e Upregulates BDNF via CREB-dependent mechanisms, enhancing TrkB signaling for synaptic strengthening and LTP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSerotonergic System:\u003c\/strong\u003e Enhances 5-HT firing and release in dorsal raphe nucleus for studying serotonergic mood and cognition.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePE-22-28\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/pp-22-28\"\u003ePE-22-28\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/semax\"\u003eSemax\u003c\/a\u003e, \u003ca href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e, and \u003ca href=\"\/products\/pinealon\"\u003ePinealon\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNootropic \u0026amp; Cognitive Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995751969098,"sku":"PBL-PE-22-28-6G","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pe-22-28-nootropic-peptide-10mg-research-grade.webp?v=1773933888","url":"https:\/\/peptides-biolab.com\/products\/pe-22-28","provider":"Peptides BioLab","version":"1.0","type":"link"}