{"product_id":"pt-141","title":"PT 141","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003ePT-141 — Selective MC3R\/MC4R Agonist for Central Melanocortin Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePT-141\u003c\/strong\u003e (Bremelanotide) is a cyclic heptapeptide derived from Melanotan II via C-terminal carboxylation. Selective for MC3R\/MC4R over MC1R — minimal melanogenic activity while retaining CNS effects. Key tool for hypothalamic melanocortin signaling research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003ePT-141 activates MC4R\/MC3R in hypothalamic nuclei via Gs-cAMP signaling. Effects mediated through CNS pathways, not peripheral vascular mechanisms. MC4R activation triggers descending spinal projections to autonomic preganglionic neurons, modulating sympathetic and parasympathetic outflow.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMC4R Signaling:\u003c\/strong\u003e Selective tool for studying MC4R-mediated CNS signaling distinct from peripheral MC1R activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAutonomic Nervous System:\u003c\/strong\u003e Modulates autonomic outflow through hypothalamic-spinal pathways, studying central melanocortin regulation of peripheral function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanocortin Structure-Activity:\u003c\/strong\u003e Metabolite-derived analog showing how subtle modifications alter MC receptor subtype selectivity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrine Integration:\u003c\/strong\u003e MC4R neurons integrate leptin, insulin, and orexin inputs — studying converging hypothalamic pathways.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003ePT-141\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e, \u003ca href=\"\/products\/kisspeptin\"\u003eKisspeptin\u003c\/a\u003e, and \u003ca href=\"\/products\/vip\"\u003eVIP\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/cognitive-function\"\u003eNeurological Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753705802,"sku":"PBL-PT141-10MG","price":34.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-pt-141-bremelanotide-peptide-10mg-research-grade.webp?v=1773933893","url":"https:\/\/peptides-biolab.com\/products\/pt-141","provider":"Peptides BioLab","version":"1.0","type":"link"}