{"product_id":"sermorelin","title":"Sermorelin","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eSermorelin — Growth Hormone-Releasing Hormone Analog for Endocrine Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSermorelin\u003c\/strong\u003e (GHRH 1-29 NH₂) is a synthetic peptide analog corresponding to the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH 1-44), which retains full biological activity at the GHRH receptor. Originally developed at Tulane University by Nobel laureate Roger Guillemin's group and subsequently approved by the FDA for diagnostic use (Geref®), Sermorelin has served as a foundational research tool in neuroendocrine physiology for over three decades. Its well-characterized pharmacology and established safety profile in clinical studies make it one of the most extensively studied GH secretagogues in the peptide research field.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSermorelin\u003c\/strong\u003e binds the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells, activating the Gsα\/adenylyl cyclase\/cAMP\/PKA signaling cascade. This triggers GH gene transcription, GH granule exocytosis, and somatotroph cell proliferation. Unlike direct GH administration, Sermorelin preserves the physiological pulsatile GH secretion pattern and maintains negative feedback via IGF-1 and somatostatin. The compound's 29-amino acid structure represents the minimum active fragment of GHRH, with the C-terminal amidation enhancing receptor binding affinity and proteolytic stability compared to the native hormone.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGH Axis Physiology:\u003c\/strong\u003e \u003cstrong\u003eSermorelin\u003c\/strong\u003e remains the standard GHRH receptor agonist for pituitary function testing, enabling researchers to assess somatotroph reserve capacity, GHRH receptor expression, and hypothalamic-pituitary feedback integrity in both normal and pathological models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related GH Decline:\u003c\/strong\u003e Research has documented that Sermorelin restores pulsatile GH secretion amplitude in aged animal models, normalizing IGF-1 levels and improving body composition parameters (lean mass\/fat mass ratio) without the supraphysiological effects of exogenous GH.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Secretagogue Studies:\u003c\/strong\u003e Researchers frequently combine Sermorelin with GHRP-class peptides (GHRP-2, GHRP-6, Ipamorelin) to study the synergistic amplification of GH release through simultaneous GHRH receptor and ghrelin receptor activation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSleep and Circadian Research:\u003c\/strong\u003e EEG-monitored studies have demonstrated that Sermorelin enhances slow-wave sleep duration and delta wave power in both young and aged subjects, correlating with augmented nocturnal GH pulse amplitude.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 2mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3,357.88 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eSermorelin\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying the GH axis may also find these compounds relevant: \u003ca href=\"\/products\/cjc-1295-without-dac\"\u003eCJC-1295\u003c\/a\u003e, \u003ca href=\"\/products\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, and \u003ca href=\"\/products\/ghrp-2\"\u003eGHRP-2\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/growth-hormone\"\u003eGrowth Hormone Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420787204426,"sku":"PBL-SERMORELIN-2MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-sermorelin-peptide-2mg-research-grade.webp?v=1774393600","url":"https:\/\/peptides-biolab.com\/products\/sermorelin","provider":"Peptides BioLab","version":"1.0","type":"link"}