{"product_id":"tb-500-fragment","title":"TB-500 Fragment","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eTB-500 Fragment — Active Core Sequence of Thymosin Beta-4 for Targeted Tissue Repair Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e is a synthetic peptide corresponding to the active region (amino acids 17-23, Ac-SDKP) of Thymosin Beta-4 (Tβ4), a 43-amino acid polypeptide originally isolated from the thymus gland. While full-length TB-500 has been widely studied for its tissue repair and anti-inflammatory properties, this fragment isolates the minimum pharmacophoric sequence responsible for the compound's principal biological activities: actin sequestration, cell migration promotion, and anti-fibrotic signaling. This targeted fragment allows researchers to investigate structure-activity relationships within the Tβ4 sequence with greater molecular precision.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eThe \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e retains the core Ac-SDKP tetrapeptide motif that interacts with G-actin monomers, modulating actin polymerization dynamics. By sequestering G-actin, the fragment influences lamellipodia formation and directional cell migration. Published studies in \u003cem\u003eAnnals of the New York Academy of Sciences\u003c\/em\u003e have demonstrated that this active sequence promotes endothelial cell migration and tubulogenesis through upregulation of VEGF and Ang-1 expression. Additionally, Ac-SDKP has been shown to inhibit TGF-β\/Smad signaling, reducing collagen I and III deposition by activated fibroblasts, which underlies its anti-fibrotic properties observed in preclinical cardiac and renal fibrosis models.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Repair Mechanisms:\u003c\/strong\u003e Researchers have utilized \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e to study the minimal structural requirements for Tβ4-mediated tissue repair, demonstrating that the Ac-SDKP core sequence is sufficient to promote keratinocyte and fibroblast migration in wound healing assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Fibrotic Pathways:\u003c\/strong\u003e Published studies in \u003cem\u003eKidney International\u003c\/em\u003e have shown that Ac-SDKP inhibits renal fibrosis progression by suppressing TGF-β1\/Smad3 signaling and reducing α-SMA expression in myofibroblasts, establishing a model for anti-fibrotic compound evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAngiogenesis Research:\u003c\/strong\u003e The fragment has been studied in chorioallantoic membrane (CAM) and Matrigel plug assays, demonstrating pro-angiogenic activity through enhanced endothelial cell proliferation, migration, and capillary network formation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Injury Models:\u003c\/strong\u003e Investigators have examined TB-500 Fragment's effects in murine myocardial infarction models, documenting reduced scar formation and improved cardiac function parameters, with mechanism studies pointing to both anti-inflammatory and pro-survival signaling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eTB-500 Fragment\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/tb-500-fragment\"\u003eTB-500 Fragment\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying tissue repair and regenerative pathways may also find these compounds relevant: \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420647121226,"sku":"PBL-TB500-FRAG-10MG","price":39.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-tb-500-fragment-10mg-research-grade.webp?v=1774393548","url":"https:\/\/peptides-biolab.com\/products\/tb-500-fragment","provider":"Peptides BioLab","version":"1.0","type":"link"}