{"product_id":"tb-500","title":"TB-500","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eTB-500 — Thymosin Beta-4 Active Fragment for Actin Regulation and Tissue Repair Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTB-500\u003c\/strong\u003e (Thymosin Beta-4 Fragment) contains the active region of Tβ4, the primary G-actin sequestering molecule. Promotes cell migration, angiogenesis, and tissue repair. Expressed in virtually all cell types. Research by Goldstein et al. and Sosne et al.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eTB-500 promotes migration via the LKKTET motif, modulating actin polymerization. Upregulates Akt\/PI3K survival signaling, promotes VEGF-dependent and -independent angiogenesis. \u003cem\u003eNature\u003c\/em\u003e (2004) demonstrated functional cardiac regeneration via epicardial cell activation.\u003c\/p\u003e\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Migration and Wound Healing:\u003c\/strong\u003e Modulates actin dynamics and lamellipodium formation. Accelerated wound closure, enhanced granulation, improved remodeling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAngiogenesis Research:\u003c\/strong\u003e Promotes new vessel formation through VEGF pathways and direct endothelial cell migration in matrigel assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Regeneration:\u003c\/strong\u003e Landmark: Tβ4 activates epicardial progenitors post-MI, promoting neovascularization and functional recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory Mechanisms:\u003c\/strong\u003e Reduces NF-κB inflammatory gene expression with decreased neutrophil infiltration and pro-inflammatory cytokines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eTB-500\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our \u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.\u003c\/p\u003e\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying related pathways may also find these compounds relevant: \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e, and \u003ca href=\"\/products\/peg-mgf\"\u003ePEG-MGF\u003c\/a\u003e. Browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery \u0026amp; Tissue Repair\u003c\/a\u003e collection.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":60995753640266,"sku":"PBL-TB-500-10MG","price":49.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-tb-500-thymosin-beta-4-peptide-10mg-research-grade.webp?v=1773933902","url":"https:\/\/peptides-biolab.com\/products\/tb-500","provider":"Peptides BioLab","version":"1.0","type":"link"}