{"product_id":"testagen","title":"Testagen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eTestagen (Lys-Glu-Asp-Gly) — Testicular Bioregulator Peptide for Reproductive Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTestagen\u003c\/strong\u003e is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Gly) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson's research group. As a tissue-specific bioregulator targeting testicular function, Testagen has been investigated for its capacity to normalize gonadal peptide regulation and modulate Leydig cell activity in preclinical models. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e has demonstrated its role in restoring age-related declines in reproductive hormone synthesis and spermatogenesis parameters.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eTestagen\u003c\/strong\u003e operates through the characteristic bioregulator mechanism described by Khavinson—direct interaction with specific DNA sequences to modulate gene expression. The KEDG tetrapeptide has been shown to bind complementary nucleotide sequences in the promoter regions of genes involved in steroidogenesis, particularly those encoding steroidogenic acute regulatory protein (StAR) and cytochrome P450 enzymes (CYP11A1, CYP17A1) essential for testosterone biosynthesis. This epigenetic regulation normalizes transcriptional activity without supraphysiological stimulation.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLeydig Cell Function:\u003c\/strong\u003e In-vitro studies on primary Leydig cell cultures have demonstrated that \u003cstrong\u003eTestagen\u003c\/strong\u003e restores testosterone production capacity in cells exposed to age-mimicking oxidative stress conditions, increasing StAR protein expression and cholesterol transport to mitochondria.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpermatogenesis:\u003c\/strong\u003e Research in aged rodent models has shown normalization of spermatogenic epithelium architecture and increased sperm motility parameters following Testagen administration, with effects persisting beyond the treatment period.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrine Regulation:\u003c\/strong\u003e Studies have observed restoration of hypothalamic-pituitary-gonadal (HPG) axis sensitivity in aged models, with normalized GnRH pulsatility and LH response patterns.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReproductive Aging:\u003c\/strong\u003e Long-term studies have investigated Testagen's capacity to delay age-related testicular involution, with histological analyses showing preserved seminiferous tubule integrity and interstitial tissue architecture.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu-Asp-Gly (KEDG)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 433.46 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eTestagen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying reproductive biology and endocrine regulation may also find these compounds relevant: \u003ca href=\"\/products\/kisspeptin\"\u003eKisspeptin\u003c\/a\u003e, \u003ca href=\"\/products\/melanotan-ii\"\u003eMelanotan II\u003c\/a\u003e, and \u003ca href=\"\/products\/pt-141\"\u003ePT-141\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/sexual-health\"\u003eSexual Health Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737823050,"sku":"PBL-TESTAGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-testagen-bioregulator-peptide-10mg-research-grade.webp?v=1774393567","url":"https:\/\/peptides-biolab.com\/products\/testagen","provider":"Peptides BioLab","version":"1.0","type":"link"}