{"product_id":"vesugen","title":"Vesugen","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eVesugen (Lys-Glu-Asp) — Vascular Bioregulator Peptide for Cardiovascular Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eVesugen\u003c\/strong\u003e is a synthetic tripeptide bioregulator (Lys-Glu-Asp) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. As a vascular-specific bioregulator, Vesugen has been characterized for its regulatory effects on endothelial cell gene expression, vascular tone maintenance, and blood vessel wall integrity. Published research in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e and \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e has documented its capacity to normalize endothelial function, restore nitric oxide signaling, and preserve vascular architecture in aged experimental models.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eVesugen\u003c\/strong\u003e interacts with DNA sequences in promoter regions of genes critical for endothelial cell function and vascular homeostasis. The KED tripeptide modulates transcription of endothelial nitric oxide synthase (eNOS), prostacyclin synthase (PGIS), and vascular endothelial growth factor receptors through chromatin remodeling at endothelial-specific gene loci. Research has demonstrated that Vesugen restores age-diminished eNOS expression and enzymatic activity, improving endothelium-dependent vasodilation capacity while simultaneously downregulating pro-thrombotic endothelin-1 (ET-1) expression.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndothelial Function:\u003c\/strong\u003e In-vitro studies on human umbilical vein endothelial cells (HUVECs) have demonstrated that \u003cstrong\u003eVesugen\u003c\/strong\u003e enhances NO production, reduces endothelial activation markers (VCAM-1, ICAM-1, E-selectin), and preserves endothelial barrier function under inflammatory stress conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVascular Aging:\u003c\/strong\u003e Research in aged murine models has shown improved flow-mediated dilation, restored aortic compliance, and reduced arterial wall thickening following chronic Vesugen administration, with effects correlated to normalized eNOS\/ET-1 expression ratios.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Atherogenic Effects:\u003c\/strong\u003e Studies have documented reduced monocyte adhesion to Vesugen-treated endothelial monolayers, decreased foam cell formation, and attenuated intimal thickening in hyperlipidemic animal models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMicrocirculation:\u003c\/strong\u003e Intravital microscopy studies have observed improved capillary perfusion patterns, normalized leukocyte rolling velocity, and reduced microvascular permeability in aged tissues following Vesugen treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu-Asp (KED tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 390.39 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eVesugen\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying vascular bioregulation may also find these compounds relevant: \u003ca href=\"\/products\/cardiogen\"\u003eCardiogen\u003c\/a\u003e, \u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e, and \u003ca href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420762497354,"sku":"PBL-VESUGEN-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-vesugen-bioregulator-peptide-10mg-research-grade.webp?v=1774393593","url":"https:\/\/peptides-biolab.com\/products\/vesugen","provider":"Peptides BioLab","version":"1.0","type":"link"}