{"product_id":"vilon","title":"Vilon","description":"\u003cdiv class=\"pb-product-desc\"\u003e\n\u003ch2\u003eVilon (Lys-Glu) — Thymic Dipeptide Bioregulator for Immune Research\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eVilon\u003c\/strong\u003e (Lys-Glu) is a synthetic dipeptide bioregulator developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. As the shortest known peptide with demonstrated immunomodulatory activity, Vilon has been the subject of extensive research published in \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e and other peer-reviewed journals. This dipeptide mimics the regulatory activity of thymic peptide extracts, modulating T-lymphocyte differentiation and immune function at remarkably low concentrations.\u003c\/p\u003e\n\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eVilon\u003c\/strong\u003e interacts with specific DNA sequences in the promoter regions of genes involved in immune regulation, particularly those governing T-cell differentiation and cytokine production. Research has demonstrated that the Lys-Glu dipeptide binds to the minor groove of double-stranded DNA, modulating chromatin conformation and transcription factor accessibility. This epigenetic mechanism allows Vilon to regulate gene expression without direct receptor-mediated signaling, a hallmark of Khavinson's bioregulator peptide class.\u003c\/p\u003e\n\n\u003ch3\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eT-Cell Differentiation:\u003c\/strong\u003e In-vitro studies have demonstrated that \u003cstrong\u003eVilon\u003c\/strong\u003e promotes CD4+ and CD8+ T-lymphocyte maturation from thymocyte precursors, restoring thymic output parameters in aged animal models to levels comparable to younger controls.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosenescence:\u003c\/strong\u003e Research on aged rodent models has shown that Vilon administration normalizes the CD4\/CD8 ratio, restores delayed-type hypersensitivity responses, and enhances natural killer cell cytotoxicity against tumor target cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Modulation:\u003c\/strong\u003e Microarray studies have identified Vilon-responsive gene clusters involved in immune surveillance, apoptosis regulation, and antioxidant defense, demonstrating broad transcriptomic effects from a minimal peptide structure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Bioregulation:\u003c\/strong\u003e Combined treatment with Vilon and \u003ca href=\"\/products\/epitalon\"\u003eEpitalon\u003c\/a\u003e has shown enhanced immune restoration effects in preclinical models, suggesting complementary mechanisms between thymic and pineal bioregulators.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu (KE dipeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 275.30 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C, protected from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Researchers Choose Peptides BioLab\u003c\/h3\u003e\n\u003cp\u003eEvery batch of \u003cstrong\u003eVilon\u003c\/strong\u003e supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.\u003c\/p\u003e\n\n\u003ch3\u003eRelated Research Peptides\u003c\/h3\u003e\n\u003cp\u003eResearchers studying thymic bioregulation and immunology may also find these compounds relevant: \u003ca href=\"\/products\/thymalin\"\u003eThymalin\u003c\/a\u003e, \u003ca href=\"\/products\/thymosin-alpha-1\"\u003eThymosin Alpha-1\u003c\/a\u003e, and \u003ca href=\"\/products\/ll-37\"\u003eLL-37\u003c\/a\u003e. For a complete overview, browse our \u003ca href=\"\/collections\/recovery\"\u003eRecovery Research\u003c\/a\u003e collection.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Peptides BioLab","offers":[{"title":"Default Title","offer_id":61420737626442,"sku":"PBL-VILON-10MG","price":29.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/9429\/6906\/files\/peptides-biolab-vilon-bioregulator-peptide-10mg-research-grade.webp?v=1774393564","url":"https:\/\/peptides-biolab.com\/products\/vilon","provider":"Peptides BioLab","version":"1.0","type":"link"}