N-Acetyl Epitalon Amidate
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
N-Acetyl Epitalon Amidate — Enhanced Telomerase-Activating Peptide for Longevity Research
N-Acetyl Epitalon Amidate is a pharmacologically optimized derivative of Epitalon (Epithalon), the synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. This modified form features N-terminal acetylation and C-terminal amidation, conferring significantly enhanced metabolic stability and bioavailability compared to native Epitalon. The parent compound was first described for its telomerase-activating properties in research published in Bulletin of Experimental Biology and Medicine (2003).
Mechanism of Action
N-Acetyl Epitalon Amidate activates telomerase reverse transcriptase (hTERT) gene expression, the catalytic subunit responsible for telomere elongation. The N-acetyl modification protects against aminopeptidase degradation, while C-terminal amidation increases receptor binding affinity and resistance to carboxypeptidases. Research has demonstrated that Epitalon-class peptides interact with DNA regions upstream of the hTERT promoter, modulating transcription factor binding and chromatin accessibility. Additionally, the compound influences pineal gland melatonin synthesis through neuroendocrine pathway modulation.
Key Research Areas
- Telomerase Activation: Studies on human somatic cell cultures have demonstrated that Epitalon peptides reactivate telomerase in senescent fibroblasts, extending replicative lifespan beyond the Hayflick limit while maintaining chromosomal stability and normal karyotype.
- Pineal Function and Circadian Biology: Research in aged rodent models has shown that Epitalon administration restores circadian melatonin secretion patterns, normalizes pineal gland morphology, and modulates suprachiasmatic nucleus output.
- Enhanced Pharmacokinetics: The N-acetyl amidated form demonstrates a significantly longer plasma half-life compared to native Epitalon, with studies reporting 3-5x greater stability in serum degradation assays.
- Antioxidant Gene Expression: Published data indicates upregulation of superoxide dismutase (SOD) and catalase expression following treatment, suggesting enhanced endogenous antioxidant defense capacity.
Technical Specifications
- Dosage per vial: 20mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Ac-Ala-Glu-Asp-Gly-NH₂
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of N-Acetyl Epitalon Amidate supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying telomere biology and longevity may also find these compounds relevant: Epitalon, Pinealon, and GHK-Cu. For a complete overview, browse our Anti-Aging Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
