Ovagen
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Ovagen (Glu-Asp-Leu) — Hepato-Gastrointestinal Bioregulator for Digestive Research
Ovagen is a synthetic tripeptide bioregulator (Glu-Asp-Leu) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson. Originally derived from research on hepatic and gastrointestinal tissue extracts, Ovagen has been characterized for its dual regulatory effects on liver function and gastrointestinal epithelial homeostasis. Published research in Bulletin of Experimental Biology and Medicine has documented its capacity to normalize digestive enzyme secretion, restore hepatobiliary function, and support mucosal integrity across the gastrointestinal tract in aged experimental models.
Mechanism of Action
Ovagen interacts with DNA sequences in promoter regions of genes governing both hepatocyte function and gastrointestinal epithelial differentiation. The EDL tripeptide modulates transcription of key digestive enzymes, bile acid transport proteins (BSEP, MRP2), and intestinal epithelial differentiation markers through chromatin remodeling. Research has demonstrated simultaneous normalization of hepatic phase I/II detoxification enzyme expression and intestinal brush border enzyme activity (alkaline phosphatase, sucrase-isomaltase), suggesting a coordinated regulatory effect across the digestive axis.
Key Research Areas
- Hepatobiliary Function: In-vitro studies on primary hepatocyte cultures have demonstrated that Ovagen normalizes bile acid synthesis enzyme expression (CYP7A1, CYP27A1) and enhances canalicular transport protein activity, improving bile flow parameters in perfused liver preparations.
- Gastrointestinal Epithelial Renewal: Research on intestinal organoid cultures has shown enhanced crypt cell proliferation and accelerated differentiation into absorptive enterocytes and goblet cells following Ovagen treatment, with preserved stem cell niche integrity.
- Digestive Enzyme Regulation: Studies have documented normalized pancreatic exocrine enzyme secretion (amylase, lipase, trypsin) and gastric acid output in aged animal models, restoring digestive efficiency to levels approaching younger controls.
- Gut-Liver Axis: Research has explored Ovagen's effects on the gut-liver axis, documenting improved intestinal barrier function (reduced plasma endotoxin levels) concurrent with enhanced hepatic clearance capacity in aged animal models.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Glu-Asp-Leu (EDL tripeptide)
- Molecular Weight: 375.37 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Ovagen supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying digestive bioregulation may also find these compounds relevant: Livagen, BPC-157, and KPV. For a complete overview, browse our Recovery Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
