KPV
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
KPV — Alpha-MSH C-Terminal Tripeptide for Anti-Inflammatory Research
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH, retaining anti-inflammatory properties without melanocortin receptor-mediated melanogenic activity. Characterized by Brzoska et al. (FEBS Letters, 1999).
Mechanism of Action
KPV inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation, suppressing IL-1β, IL-6, and TNF-α. Enters cells directly for receptor-independent effects. Reduces inflammation in colitis models through direct intestinal epithelial cell signaling (J Immunol). Modulates NLRP3 inflammasome.
Key Research Areas
- NF-κB Pathway: Inhibits NF-κB at multiple cascade points without broad receptor pharmacology of full-length α-MSH.
- Intestinal Inflammation: Demonstrated anti-inflammatory effects in DSS-colitis and IBD models with reduced mucosal damage and neutrophil infiltration.
- Skin Inflammation: Reduces IL-8 and TNF-α in UV-irradiated and LPS-stimulated skin cell models.
- Innate Immune Modulation: Modulates macrophage and dendritic cell inflammatory responses while preserving antimicrobial functions.
Why Researchers Choose Peptides BioLab
Every batch of KPV supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our KPV is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: LL-37, BPC-157, and Thymosin Alpha-1. Browse our Immunomodulatory Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
