LL-37
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
LL-37 — Human Cathelicidin Antimicrobial Peptide for Innate Immunity Research
LL-37 is a 37-amino acid cationic antimicrobial peptide — the only human cathelicidin. Cleaved from hCAP18 by proteinase 3, it adopts an amphipathic alpha-helix for membrane disruption. Sequenced by Gudmundsson et al. (1996). Active against bacteria, fungi, and enveloped viruses.
Mechanism of Action
LL-37 disrupts microbial membranes through electrostatic attraction to anionic phospholipids via carpet model, toroidal pore, and membrane thinning mechanisms. Also activates FPRL1, promotes chemotaxis, stimulates angiogenesis, and modulates TLR signaling. Forms DNA complexes activating dendritic cells via TLR9 (Nature Medicine).
Key Research Areas
- Antimicrobial Mechanisms: Broad-spectrum activity against Gram+/- bacteria, fungi, viruses. Physical mode of action resists pathogen adaptation.
- Innate Immune Signaling: Activates FPRL1, P2X7, EGFR, triggering chemotaxis and cytokine responses bridging innate and adaptive immunity.
- Wound Healing: EGFR transactivation stimulates keratinocyte migration for re-epithelialization.
- Biofilm Research: Anti-biofilm activity at sub-MIC concentrations against P. aeruginosa and S. aureus.
Why Researchers Choose Peptides BioLab
Every batch of LL-37 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our LL-37 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: KPV, Thymosin Alpha-1, and BPC-157. Browse our Immunomodulatory Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
