Chonluten
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Chonluten (Glu-Asp-Gly) — Pulmonary/Gastrointestinal Bioregulator for Mucosal Tissue Research
Chonluten is a synthetic tripeptide bioregulator (Glu-Asp-Gly) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson. This short bioregulator peptide has been characterized for its dual tissue specificity, demonstrating regulatory effects on both bronchial mucosal and gastrointestinal epithelial tissue gene expression. Published research in Bulletin of Experimental Biology and Medicine has documented its ability to normalize mucosal barrier function, restore epithelial turnover kinetics, and modulate local immune responses in both respiratory and digestive tract tissue models.
Mechanism of Action
Chonluten interacts with DNA sequences in promoter regions of genes governing mucosal epithelial integrity across multiple organ systems. The EDG tripeptide modulates transcription of tight junction proteins (ZO-1, claudins), mucin genes (MUC2, MUC5AC), and defensin antimicrobial peptides through chromatin remodeling at tissue-specific loci. Research has demonstrated that Chonluten simultaneously upregulates epithelial repair mechanisms while modulating the innate immune response at mucosal surfaces, maintaining the delicate balance between barrier defense and inflammatory control.
Key Research Areas
- Mucosal Barrier Function: Trans-epithelial electrical resistance (TEER) measurements have demonstrated that Chonluten enhances barrier integrity in both Caco-2 intestinal monolayers and primary bronchial epithelial cell cultures, with significant upregulation of tight junction protein expression.
- Epithelial Regeneration: Wound healing assays on mucosal epithelial cell monolayers have shown accelerated gap closure and enhanced proliferative response following Chonluten treatment, with increased Ki-67 positivity and reduced apoptotic indices in the wound margin.
- Mucosal Immunity: Research has observed modulation of secretory IgA production and defensin expression at mucosal surfaces, suggesting that Chonluten supports local antimicrobial defense while preventing excessive inflammatory activation.
- Age-Related Mucosal Changes: Histological studies in aged animal gastrointestinal tissue have documented preserved villus height, maintained crypt depth ratio, and normalized goblet cell density following chronic Chonluten administration.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Glu-Asp-Gly (EDG tripeptide)
- Molecular Weight: 319.27 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Chonluten supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying mucosal bioregulation may also find these compounds relevant: BPC-157, KPV, and LL-37. For a complete overview, browse our Recovery Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
